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What is AOD-9604

AOD-9604 is a synthetic peptide derived from the C-terminal fragment of human growth hormone (hGH), amino acids 177-191. It is specifically engineered to influence lipid metabolism without inducing the typical growth-promoting effects of hGH. AOD-9604 stimulates lipolysis, the breakdown of fat, and inhibits lipogenesis, the formation of new fat stores, by mimicking the activity of natural hGH in adipose tissues.

This targeted mechanism has made it a promising candidate for obesity management and metabolic disorder research. Its ability to selectively modulate fat metabolism without impacting blood sugar levels highlights its potential as a safe and specialized therapeutic agent [1].

Molecular Formula: C78H123N23O23S2

Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys(1)-Arg-Ser-Val-Glu-Gly-Ser-Cys(1)-Gly-Phe-OH

Source: PubChem

AOD-9604 Structure  from PharmaLabGlobal

Molecular Weight: 1815.1 g/mol

View the HPLC Certificate here.

AOD 9604 Spray nasale ai peptidi 30ml

Potential Benefits of AOD-9604

Buy AOD-9604 Nasal Spray from PharmaLabGlobal. 

AOD-9604 Mechanism of Action

AOD-9604 is a synthetic peptide derived specifically from amino acids 177-191 of the human growth hormone (hGH). This fragment is meticulously designed to replicate the fat-reducing effects of hGH without triggering its broader growth-promoting activities [1].

The peptide exerts its action by selectively targeting adipose (fat) tissue. It stimulates lipolysis, the biochemical process where stored triglycerides in fat cells are broken down into free fatty acids and glycerol for energy use [2]. Concurrently, it inhibits lipogenesis, the metabolic pathway that creates new fat stores from excess calories. This dual action helps reduce accumulated fat while preventing further fat deposition.

Unlike hGH, research professionals have found that AOD-9604 does not engage with growth hormone receptors, making it a safer option with minimized systemic effects. Importantly, it does not alter blood glucose levels, as it bypasses insulin pathways. This specificity renders AOD-9604 a promising agent for obesity management and research focused on metabolic disorders linked to adiposity [3].

Buy AOD-9604 – available in 2mg, 5mg and 10 mg Peptide Vials for research use only.

Buy AOD-9604  peptide from PharmaLabGlobal

Possible Clinical Applications of AOD-9604

AOD-9604 has been the subject of multiple clinical trials. Not yet approved for human consumption, further research is required to establish its efficacy in the following areas:

Stimulates Fat Metabolism

AOD-9604 enhances fat metabolism through two primary mechanisms. It promotes lipolysis, a process where stored triglycerides within adipose tissue are broken down into free fatty acids and glycerol, which can then be used as energy. Simultaneously, it inhibits lipogenesis, the metabolic pathway responsible for converting excess calories into fat storage. By targeting only adipose cells, AOD-9604 ensures selective fat reduction without affecting lean muscle tissue. Unlike human growth hormone, from which it is derived, AOD-9604 does not interact with growth hormone receptors, minimizing systemic effects. Its precision makes it a promising peptide for managing fat accumulation and supporting metabolic health [4].

Preserves Muscle Mass

AOD-9604 preserves muscle mass while promoting fat loss by leveraging its targeted action on adipose tissue. This synthetic peptide, derived from the fragment 177-191 of human growth hormone (hGH), is designed to selectively stimulate fat metabolism without engaging growth hormone receptors that influence tissues beyond fat cells [2].

The peptide initiates lipolysis, breaking down stored triglycerides in fat cells into energy-releasing free fatty acids and glycerol. Simultaneously, it inhibits lipogenesis, the production of new fat stores. Importantly, AOD-9604’s selective mechanism ensures these processes are confined to adipose tissue, sparing muscle cells from metabolic disruption [4].

Maintains Blood Sugar Levels

Research has found that unlike human growth hormone, AOD-9604 does not activate growth hormone receptors or pathways linked to broader metabolic effects, including those influencing blood glucose levels. Its precision ensures that it bypasses insulin-related mechanisms, making it metabolically neutral with respect to glucose homeostasis. This characteristic is particularly relevant for individuals concerned with managing blood sugar levels, as it minimizes the risk of hyperglycemia or other glucose-related side effects while promoting fat loss [5].

AOD-9604 is available in a pre-mixed peptide solution – which does not require peptide reconstitution. Buy AOD-9604 Pre-Mixed Peptide Kit.

AOD-9604 BPC-157 Stack  from PharmaLabGlobal

Buy AOD-9604 BPC-157 Peptide Combo

Stacking AOD-9604 and BPC-157 peptides offers potential complementary benefits for individuals aiming to enhance health and body composition. AOD-9604 focuses on fat metabolism, promoting lipolysis and reducing fat storage without impacting muscle mass. This makes it an effective agent for weight management and targeted fat loss.

On the other hand, BPC-157 is renowned for its tissue repair properties, aiding in healing injuries, reducing inflammation, and improving gut health. Together, these peptides may create a synergistic effect, combining fat reduction with enhanced recovery and overall well-being. Their collaborative action supports goals related to recovery, lean body maintenance, and optimal metabolic health.

View the carefully selected Peptide Combos from PharmaLabGlobal

Buy AOD-9604 BPC-157 Peptide Combo.

Frequently Asked Questions about AOD-9604

Can AOD-9604 reduce stubborn fat?

Yes, AOD-9604 has been shown to target and reduce stubborn fat, reducing body weight. This peptide, derived from a fragment of human growth hormone, specifically promotes lipolysis (fat breakdown) and inhibits lipogenesis (fat accumulation). It works by targeting fat cells directly, particularly in areas of stubborn fat, without affecting blood sugar levels or muscle mass. This makes it a promising option for body fat reduction while preserving lean body composition. However, its use is primarily for research purposes, and further studies are needed to fully understand its long-term effects and applications before it is approved by drug administration agencies or the FDA.

Does AOD-9604 have any benefits for joint health?

Yes, AOD-9604 may offer potential benefits for bones, cartilage and joints. Research suggests that it can promote cartilage repair and support joint health due to its regenerative properties. Additionally, AOD-9604 has been studied for its ability to reduce inflammation, which can alleviate joint pain and improve mobility, particularly in conditions like osteoarthritis. Its role in stimulating growth factors may also contribute to better bone density and overall joint function.


All products advertised and supplied by PharmaLabGlobal are intended for research use only. 

Buy AOD-9604  Peptide Vial 2mg Bulk Buy from PharmaLabGlobal

Does AOD-9604 have any side effects?

AOD-9604 is generally considered to have a favourable safety profile, with minimal reported side effects in research studies. Unlike full-length human growth hormone, it does not appear to affect blood sugar levels, insulin sensitivity, or other hormonal pathways, which reduces the risk of significant metabolic side effects. Some reported adverse effects include headaches and nausea.

Scientific Research

[1] Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D. Detection and in vitro metabolism of AOD9604. Drug Test Anal. 2015 Jan;7(1):31-8. 

[2] Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9.

[3] Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. 

[4] Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9.

[5] Stier H, Vos E, Kenley D, Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology and Metabolism, North America, 3, apr. 2013.

Further Reading:

Discovering the Top Weight Loss Peptides

The blog on Pharma Lab Global explores the potential of weight loss peptides in addressing obesity and enhancing fat metabolism. It highlights peptides like Tesamorelin, AOD-9604, Tesofensine, FTPP, and MOTS-c, detailing their unique mechanisms such as stimulating lipolysis, improving metabolic efficiency, and regulating appetite. Tesamorelin focuses on reducing visceral fat while preserving muscle, AOD-9604 targets fat metabolism without affecting blood sugar, and Tesofensine suppresses appetite by modulating neurotransmitters. FTPP induces fat cell apoptosis, and MOTS-c enhances mitochondrial function for better energy utilization. The blog emphasizes ongoing research and the promising future of peptides in weight management and metabolic health.

AOD 9604 Nasal Spray: Fat Loss and Muscle Preservation

We discuss the benefits of AOD 9604 nasal spray, a peptide designed for fat loss and muscle preservation. It explains how AOD 9604 targets fat cells, promoting lipolysis and metabolic efficiency without affecting insulin resistance or blood sugar levels. The spray also supports muscle recovery, reduces inflammation, and aids in healing, making it ideal for athletes and fitness enthusiasts. Highlighting its safety and effectiveness, the blog emphasizes its potential for weight management and overall metabolic health, while noting its research-focused use and the need for further studies to confirm long-term benefits.

Reducing Obesity with GHRP-2 Peptide

The blog on Pharma Lab Global explores the potential of GHRP-2 nasal spray in promoting fat loss and lean muscle preservation. It highlights GHRP-2’s ability to stimulate growth hormone release by activating the ghrelin receptor, which enhances lipolysis and energy utilization. The article compares GHRP-2 with other peptides like AOD-9604, Tesamorelin, and Tesofensine, emphasizing their unique mechanisms in addressing obesity, such as appetite suppression and targeted fat reduction. It also discusses the potential of combining peptides for a multi-faceted approach to weight management, while stressing the importance of responsible research use and further studies to confirm their efficacy.

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