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B7-33 Peptide

What is B7-33 Peptide?

B7-33 peptide is a synthetic analogue of human relaxin-2, designed to harness the beneficial effects of relaxin signalling while minimizing unwanted side effects. It primarily targets the relaxin receptor RXFP1, promoting anti-fibrotic, anti-inflammatory, and cardiovascular protective effects. Unlike traditional relaxin therapies, B7-33 is engineered to selectively activate pathways that reduce fibrosis (excessive tissue scarring), making it a promising candidate for treating conditions such as cardiac fibrosis, pulmonary fibrosis, the treatment of acute heart failure and organ damage [1].

In addition to its tissue-protective properties, B7-33 has shown potential in reducing blood pressure, enhancing wound healing, and improving vascular function. Its ability to modulate the extracellular matrix makes it valuable in regenerative medicine and heart failure treatment. Unlike full-length relaxin, B7-33 offers a more targeted, safer alternative with fewer systemic effects. Research is ongoing to explore its full therapeutic potential, particularly in cardiovascular and fibrotic diseases [2].

Amino Acid Sequence: VIKLSGRELVR AQIAISGMSTWS KRSL

View B7-33 HPLC Certificate

B7-33-Peptide-Vial
b7-33 30ml nasal 8mg

Benefits of B7-33 Peptide

Buy B7-33 – Available in 2mg or 6mg peptide vials.

Mechanisms of B7-33 Peptide

B7-33 peptide is a synthetic analogue of human relaxin-2 that selectively activates the relaxin family peptide receptor  RXFP1 to promote anti-fibrotic, anti-inflammatory, and cardiovascular protective effects [3]. Unlike full-length relaxin, B7-33 is designed to specifically activate pathways that reduce fibrosis while avoiding unnecessary systemic effects.

Upon binding to RXFP1 receptors, B7-33 stimulates nitric oxide (NO) production, leading to vasodilation and improved blood flow, which helps lower blood pressure and reduce cardiac strain. Additionally, it inhibits TGF-β signalling, a key driver of fibrosis and excessive tissue scarring, preventing collagen build up in organs like the heart, lungs, and liver [3].

B7-33 also modulates the extracellular matrix, supporting tissue repair and regeneration while reducing inflammation. Its ability to target fibrotic and cardiovascular pathways makes it a promising therapy for conditions such as heart failure, pulmonary fibrosis, and chronic inflammatory diseases.

B7-33 Peptide Nasal Sprays are a non-invasive and convenient way of researching B7-33 . Available in 15ml or 30ml Peptide Nasal Sprays.

Buy B7-33  Peptide from PharmaLabGlobal

Possible Clinical Applications of B7-33 Peptide

Scientific researchers using both human and animal models have suggested the B7-33 may have the following clinical applications:

Treatment for Fibrosis

B7-33 peptide shows strong potential in treating fibrosis by selectively activating the relaxin receptor RXFP1, which regulates tissue remodelling and repair. It inhibits TGF-β signalling, a major driver of fibrosis, preventing excessive collagen build up and scar tissue formation in organs like the heart, lungs, liver, and kidneys [2]. Additionally, B7-33 enhances nitric oxide (NO) production, improving blood flow and reducing inflammation, further limiting fibrotic progression. Unlike traditional therapies, B7-33 targets fibrosis at its source while minimizing side effects, making it a promising candidate for treating cardiac, pulmonary, and organ fibrosis in various chronic conditions [3].

Cardiovascular Protection

B7-33 peptide hormone offers significant cardiovascular protection by targeting the relaxin receptor RXFP1, which plays a key role in vasodilation, anti-fibrotic activity, and heart function. One of its primary mechanisms is the stimulation of nitric oxide (NO) production, which relaxes blood vessels, improves circulation, and helps lower blood pressure, reducing strain on the heart [3].

Additionally, in vitro testing has shown that B7-33 inhibits TGF-β signalling, preventing cardiac fibrosis—a condition where excessive collagen build up stiffens the heart muscle, leading to heart failure and reduced cardiac efficiency. By reducing inflammation and oxidative stress, B7-33 helps maintain healthy heart tissue, improving overall cardiovascular function [4].

Unlike traditional relaxin-based therapies, B7-33 is designed to target beneficial cardiovascular pathways with fewer systemic side effects. Its ability to support vascular health, prevent fibrosis, and enhance cardiac function makes it a promising candidate for treating hypertension, heart failure, and other cardiovascular diseases. Research continues to explore its full therapeutic potential.

Anti-Inflammatory

B7-33 peptide exhibits potent anti-inflammatory properties by selectively activating the relaxin receptor RXFP1, which regulates immune responses and tissue repair. One of its key mechanisms is the inhibition of pro-inflammatory cytokines, such as TNF-α and IL-6, which contribute to chronic inflammation and tissue damage [3]. By suppressing these inflammatory signals, B7-33 helps protect organs from fibrotic and degenerative diseases.

Additionally, B7-33 reduces TGF-β signalling, a major driver of inflammation-induced fibrosis, preventing excessive scar tissue formation in the heart, lungs, liver, and kidneys. It also enhances nitric oxide (NO) production, which helps regulate immune function and improves vascular health [5].

Unlike conventional anti-inflammatory drugs, B7-33 does not merely block inflammation but modulates the body’s natural healing processes, promoting balanced immune responses. This makes it a promising therapy for conditions like pulmonary fibrosis, heart disease, arthritis, and other chronic inflammatory disorders. Research continues to explore its full therapeutic potential.

Wound Healing and Tissue Regeneration

B7-33 peptide promotes wound healing and tissue regeneration by activating the relaxin receptor RXFP1, which enhances cell repair, reduces fibrosis, and improves blood flow. It inhibits TGF-β signalling, preventing excessive scar tissue formation while supporting the remodelling of the extracellular matrix. Additionally, B7-33 stimulates nitric oxide (NO) production, leading to better oxygenation and nutrient delivery to damaged tissues. Its anti-inflammatory properties further aid in reducing swelling and accelerating recovery. By promoting healthy tissue regeneration rather than excessive scarring, B7-33 is a promising candidate for wound healing, surgical recovery, and regenerative medicine applications [6].

PharmaLabGlobal supplies Peptide Pen Kits, supplied with pre-mixed peptide cartridges, no peptide reconstitution required. Buy B7-33 Pre-Mixed Peptide Pen.

Buy B7-33 Pre-mixed Pen  from PharmaLabGlobal

B7-33 FAQ's

Which is more efficient, peptide injections or peptide nasal sprays?

The efficacy of different ways of administering peptides is currently under investigations in vivo studies. The effectiveness of administration method also depends on the mechanism of action of the peptide and potential benefits.

What makes B7-33 unique compared to other peptides?

Unlike its parent hormone relaxin-2, B7-33 is a single-chain peptide, making it simpler and less expensive to produce. It selectively activates specific signaling pathways, reducing potential side effects.

Scientific Research

[1] Devarakonda T, Mauro AG, Guzman G, Hovsepian S, Cain C, Das A, Praveen P, Hossain MA, Salloum FN. B7-33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction-Related Adverse Cardiac Remodeling in Mice. Eur J Pharmacol, J Am Heart Assoc. 2020 Apr 21;9(8):e015748. 

[2] Alam F, Gaspari TA, Kemp-Harper BK, Low E, Aw A, Ferens D, Spizzo I, Jefferis AM, Praveen P, Widdop RE, Bathgate RAD, Hossain MA, Samuel CS. The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy. Biomed Pharmacother. 2023 Apr;160:114370. 

[3] Devarakonda T, Mauro AG, Guzman G, Hovsepian S, Cain C, Das A, Praveen P, Hossain MA, Salloum FN. B7-33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction-Related Adverse Cardiac Remodeling in Mice. J Am Heart Assoc. 2020 Apr 21;9(8):e015748.

[4] Schimmel K, Ichimura K, Reddy S, Haddad F, Spiekerkoetter E. Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target. Front Cardiovasc Med. 2022 May 6;9:886553.

[5] Kim KK, Sheppard D, Chapman HA. TGF-β1 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a022293. 

[6] Chrishan S. Samuel, Robert G. Bennett, Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions, Biochemical Pharmacology,
Volume 197, 2022, 114884.

Further Reading:

B7-33 Peptide: A Promising Research Compound for Inflammation and Healing

This blog explores the potential of the B7-33 peptide in reducing inflammation and fibrosis while supporting healing. B7-33 is a synthetic peptide modelled after the hormone relaxin, which helps regulate inflammation, prevent scarring, and improve tissue repair. Unlike traditional anti-inflammatory drugs, B7-33 fine-tunes the body’s immune response, promoting healing without suppressing the immune system entirely.

It highlights B7-33 potential applications in cardiovascular health, autoimmune disorders, neurological conditions, lung diseases, and sports injuries. 

Cardiovascular Benefits of B7-33

Read about the cardiovascular benefits of the B7-33 peptide, a research compound derived from the relaxin-2 hormone. This blog highlights its potential in reducing cardiac fibrosis, inflammation, and regulating blood pressure. B7-33’s anti-fibrotic properties may improve heart elasticity and function, while its anti-inflammatory effects could mitigate cardiovascular disease progression.

Additionally, its vasodilatory potential suggests a role in blood pressure management. The blog emphasizes that B7-33 is strictly for research purposes, with ongoing studies investigating its mechanisms and long-term effects on heart health.

How Does BPC-157 Reduce Inflammation

Discover the healing properties of BPC-157, a synthetic peptide derived from human gastric juices, known for its potential in reducing inflammation and promoting tissue regeneration. It explores how BPC-157 modulates inflammatory cytokines, enhances blood vessel formation, protects against oxidative stress, and supports gut healing, particularly in counteracting NSAID-induced damage. The article also compares BPC-157 with other peptides like KPV and TB500, emphasizing its broader systemic effects on tissue repair and immune regulation. While still under research, BPC-157 shows promise in addressing chronic inflammation, gut health, and injury recovery.

Why Buy B7-33 Peptide from PharmaLabGlobal

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Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)

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