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CJC-1295 No DAC is a synthetic peptide that falls under the growth hormone-releasing hormone (GHRH) class of peptides. It is similar to CJC-1295 with DAC, but it lacks the Drug Affinity Complex (DAC) component [1]. It is often also known as Modified GRF (1-29).
This peptide is designed to stimulate the release of growth hormone from the pituitary gland in a pulsatile manner, leading to increased levels of growth hormone in the body.
CJC-1295 No DAC is often used in combination with a growth hormone-releasing peptide (GHRP) to amplify the growth hormone release effects synergistically. It is highly researched peptide for its potential benefits in promoting muscle growth, fat loss, improved recovery, and overall well-being.
Molecular Formula: C152H252N44O42
Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Molecular Weight: 3367.9 g/mol
View the HPLC Certificate here.
Source: PubChem
Buy CJC-1295 No DAC Peptide Vial online here for laboratory research purposes – Available in 2mg, 5mg & 10mg
When purchasing peptide vials from PharmaLabGlobal you will also need Bacteriostatic Water for reconstitution. Find the full range of peptide accessories here.
CJC-1295 No DAC operates by leveraging its properties as a growth hormone-releasing peptide to stimulate the pituitary gland’s secretion of growth hormone. Upon administration, this synthetic peptide interacts with specific receptors on the pituitary gland, mimicking the activity of natural growth hormone-releasing hormone (GHRH).
Researchers have found that by binding to these receptors, CJC-1295 No DAC triggers a cascade of events that prompt the controlled and rhythmic release of growth hormone in the body. This process results in elevated levels of growth hormone circulating in the bloodstream.
The pulsatile nature of growth hormone release induced by CJC-1295 No DAC is crucial for emulating the body’s natural pattern of growth hormone secretion. This controlled release mechanism helps avoid desensitization of the pituitary gland’s receptors over time, ensuring sustained effectiveness of the peptide. As a result, individuals using CJC-1295 No DAC may experience enhanced muscle growth, accelerated fat metabolism, improved recovery from exercise-induced stress, and overall well-being benefits associated with optimized growth hormone levels.
By modulating the release of growth hormone in a regulated manner, CJC-1295 No DAC offers a targeted approach to harnessing the potential benefits of increased growth hormone levels for health and performance optimization.
Purchase CJC-1295 No DAC Nasal Spray for a painless peptide administration here.
CJC-1295 without DAC (Drug Affinity Complex) has been found during clinical studies to have the following potential applications:
Muscle Growth
The increased levels of growth hormone induced by CJC-1295 No DAC play a crucial role in promoting muscle growth through various mechanisms. Growth hormone aids in protein synthesis, which is essential for muscle repair and growth. Additionally, it helps enhance nitrogen retention in muscles, supports metabolic processes that contribute to muscle development, and fosters tissue repair after exercise-induced stress [2].
Weight Loss
The increased levels of growth hormone induced by CJC-1295 No DAC can contribute to fat loss through several mechanisms including enhancing metabolic rate, which can lead to increased calorie expenditure and potentially aid in burning stored fat, and promoting lipolysis, the breakdown of fats into fatty acids, which can be utilized as an energy source by the body, aiding in fat loss [3].
Furthermore, optimal growth hormone levels can improve insulin sensitivity, potentially reducing fat storage and promoting fat utilization for energy.
Gastrointestinal Mobility
Researchers studied growth hormone releasing analogues in pursuit of similar results but without the substantial side effects. According to research, CJC-1295 without DAC interacts with VIP receptors to enhance gastrointestinal motility in monkeys [4]. In addition, VIPC1, located in the gastrointestinal, reproductive, and urinary systems, appears to interact with this peptide. Bowel motility improvement is critical in inflammatory bowel disorders with constipation [5] [6]. Currently, there are no drugs available to treat these disorders, which cause high morbidity.
Cardiovascular Advantages
Post heart attack, CJC 1295 without DAC nasal spray and other GHRH derivatives appear to increase the heart’s ability to pump blood. This could significantly improve the quality of life and reduce mortality in patients that suffer from heart failure [7]. In addition, this finding could be used to treat numerous congenital heart diseases, heart failure, pulmonary hypertension, and heart attacks.
Thyroid
GH release is frequently linked to thyroid issues. For this study, hypothyroidism patients were given CJC-1295 without DAC nasal spray to investigate this connection [8]. The researchers established a relationship between thyroid hormone and GH and found that those given T4 had higher GRF reactions. For example, changing GRF can assist scientists to comprehend human physiology in several ways [9].
Buy CJC-1295 No DAC Pre-Mixed Peptide Pen. Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal for laboratory purposes.
What does DAC mean?
DAC stands for Drug Affinity Complex. In the context of peptides like CJC-1295, DAC refers to a molecular modification that extends the half-life of the peptide in the body. The inclusion of DAC helps prolong the activity of the peptide, allowing for a sustained release of growth hormone or other desired effects over an extended period. This modification enhances the effectiveness and duration of action of the peptide, offering benefits such as prolonged stimulation of growth hormone secretion and more consistent physiological responses compared to peptides without the DAC component.
What is the difference between CJC-1295 DAC and CJC-1295 No DAC?
Whilst CJC-1295 with DAC offers a longer duration of action due to the DAC component binding to serum albumin, CJC-1295 No DAC functions without this modification, relying on the pulsatile release of growth hormone to achieve its effects.
What are the potential side effects associated with CJC-1295 No DAC?
Potential adverse effects of CJC-1295 No DAC peptide may include injection site reactions, water retention, flu-like symptoms, hypothyroidism risk, blood sugar level changes, and interactions with existing conditions or medications. Monitoring for adverse reactions and consulting a healthcare provider before use is essential to manage and minimize potential risks.
Where can I buy CJC-1295 online ?
PharmaLabGlobal is a trusted supplier of peptides online . Peptides are 99%+ purity for clinical research use.
Is CJC-1295 No DAC legal?
The legality of peptides for human consumption like CJC-1295 No DAC can vary depending on the region and intended use. In many countries, peptides are legal for research purposes or with a doctor’s prescription but may be regulated for athletic enhancement or bodybuilding. It’s essential to check local laws and regulations regarding the purchase, possession, and use of CJC-1295 No DAC.
Combining GHRP-6 and CJC-1295 No DAC peptides can offer synergistic benefits for individuals seeking to optimize their growth hormone levels.
GHRP-6, a growth hormone-releasing peptide, stimulates the pituitary gland to produce growth hormone rapidly. When paired with CJC-1295 No DAC, which sustains growth hormone release over time, the two peptides complement each other effectively.
This combination can lead to enhanced muscle growth, improved fat loss, faster recovery from exercise, increased energy levels, better sleep quality, and overall well-being.
By working together, GHRP-6 and CJC-1295 No DAC create a potent synergy that maximizes the benefits of elevated growth hormone levels.
Buy GHRP-6 & CJC-1295 No DAC Peptide Blend here from PharmaLabGlobal
[1] Muchiri RN, van Breemen RB. Drug discovery from natural products using affinity selection-mass spectrometry. Drug Discov Today Technol. 2021 Dec;40:59-63.
[2] Tavares AB, Micmacher E, Biesek S, Assumpção R, Redorat R, Veloso U, Vaisman M, Farinatti PT, Conceição F. Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old. Int J Endocrinol. 2013;2013:942030.
[3] Gertner JM. Effects of growth hormone on body fat in adults. Horm Res. 1993;40(1-3):10-5
[4] Ito T, Igarashi H, Pradhan TK, Hou W, Mantey SA, Taylor JE, Murphy WA, Coy DH, Jensen RT. GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity. Peptides. 2001 Jul;22(7):1139-51.
[5] Waelbroeck M, Robberecht P, Coy DH, Camus JC, De Neef P, Christophe J. Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology. 1985 Jun;116(6):2643-9.
[6] Igarashi H, Ito T, Pradhan TK, Mantey SA, Hou W, Coy DH, Jensen RT. Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors. J Pharmacol Exp Ther. 2002 Nov;303(2):445-60.
[7] Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M. Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. Endocrinology. 2019 Jul 1;160(7):1600-1612
[8] Valcavi R, Jordan V, Dieguez C, John R, Manicardi E, Portioli I, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon MF. Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clin Endocrinol (Oxf). 1986 Jun;24(6):693-8
[9] Dieguez C, Jordan V, Harris P, Foord S, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon MF. Growth hormone responses to growth hormone-releasing factor (1-29) in euthyroid, hypothyroid and hyperthyroid rats. J Endocrinol. 1986 Apr;109(1):53-6.
In this blog, we delve into the world of peptide stacks to uncover the ideal combination for maximizing health and performance benefits. Exploring popular peptides like GHRP-6, Ipamorelin, CJC-1295 No DAC, and others, we analyze how different peptides work synergistically to enhance muscle growth, promote fat loss, improve recovery, and boost overall well-being. Through expert insights and scientific explanations, we guide readers on selecting the most effective peptide stack tailored to their goals.
In this blog, we explore the world of weight loss peptides and their impact on achieving sustainable and healthy weight management goals. We delve into popular peptides known for their efficacy in promoting fat loss, such as CJC-1295 No DAC. Through insightful discussions and expert guidance, we shed light on how these peptides work to enhance metabolism, promote lipolysis, and support overall body composition improvements.
Muscle building peptides are specialized compounds designed to enhance muscle growth, strength, and recovery by stimulating protein synthesis, increasing muscle mass, and improving exercise performance, offering athletes and fitness enthusiasts a targeted approach to achieving their muscle-building goals. Discover how CJC-1295, GHRP-6 and IGF-1 peptides can all help stimulate muscle growth through their unique mechanisms.
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