(£) GBP (Default)
  • ($) USD
  • (€) EUR
  • ($) AUD
  • ($) CAD
  • ($) NZD
Pharma Lab Global

15% off first order with code: 1storder

Pharma Lab Global
99%+ Quality Guaranteed
Pharma Lab Global

Competitive Prices

Pharma Lab Global
Shipping Protection
Pharma Lab Global
Fast Order Process

What is FOXO4-DRI

FOXO4-DRI is a synthetic peptide designed to eliminate senescent cells by disrupting the interaction between FOXO4 and p53. Normally, FOXO4 prevents p53 from triggering apoptosis in aging cells, allowing them to persist and contribute to age-related diseases [1]. By interfering with this process, FOXO4-DRI frees p53, leading to selective apoptosis of senescent cells without harming healthy ones.

Research in animal models suggests it may improve tissue function, enhance organ health, and promote longevity.

Molecular Formula: C228H388N86O64

Amino Acid Sequence: H-LTLRKEPASEIAQSIL  EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH

Molecular Weight: 5358.05 g/mol

View the HPLC Certificate here.

Source: PubChem

Buy FOXO4-DRI  peptide from PharmaLabGlobal
FOXO4-DRI  Peptide Vial from PharmaLabGlobal

Potential Benefits of FOXO4-DRI

Buy FOXO4-DRI Peptide Vial here – Available in 10mg peptide vials.

Mechanism of Action of FOXO4-DRI

Scientific studies have found that the FOXO4-DRI peptide works by selectively inducing apoptosis in senescent cells through disruption of the interaction between FOXO4 and p53 [1]. In aging cells, FOXO4 normally binds to p53, preventing it from triggering programmed cell death. This allows senescent cells to persist, contributing to chronic inflammation and age-related diseases [3].

FOXO4-DRI is a modified peptide designed to competitively inhibit FOXO4’s interaction with p53. By blocking FOXO4 from binding to p53, the peptide restores p53’s ability to initiate apoptosis, leading to the selective clearance of senescent cells while sparing healthy ones. This targeted approach helps to reduce the harmful effects of cellular senescence, such as tissue dysfunction and inflammation [2].

Preclinical studies have demonstrated that FOXO4-DRI can improve tissue regeneration, enhance organ function, and extend lifespan in animal models. Its mechanism of action positions it as a promising senolytic therapy with potential applications in treating age-related diseases and improving overall health.

FOXO4-DRI is available in peptide nasal spray from PharmaLabGlobal . Peptide nasal sprays are a peptide stock solution available in 15ml or 30 ml bottles, offering a painless and non-invasive delivery to your clinical studies. Buy FOXO4-DRI today!

Buy FOXO4-DRI  peptide from PharmaLabGlobal

Potential Applications of FOXO4-DRI

Clinical research has indicated that FOXO4-DRI has shown promise in the following areas:

Targets senescent cells 

FOXO4-DRI is a synthetic peptide designed to target senescent cells, which are damaged cells that stop dividing but resist apoptosis (programmed cell death). It works by disrupting the interaction between the FOXO4 protein and p53, a key regulator of cell survival. In senescent cells, FOXO4 binds to p53, preventing apoptosis. FOXO4-DRI interferes with this binding, reactivating p53’s apoptotic function and selectively eliminating senescent cells [1]. By clearing these cells, FOXO4-DRI reduces inflammation and restores tissue function, potentially mitigating age-related decline and promoting healthier aging. This innovative approach of cell cycle regulation has shown promise in preclinical studies, offering a potential breakthrough in anti-aging therapies [2].

Enhances tissue repair and regeneration

FOXO4-DRI is a ground breaking peptide designed to enhance tissue repair and regeneration by targeting senescent cells. These cells, which accumulate with age, no longer divide but resist programmed cell death, contributing to inflammation and tissue dysfunction. Studies suggest that by removing the senescent cells reduces inflammation, clears damaged tissue, and creates space for healthy cells to thrive. The result is improved tissue health, faster recovery, and a renewed capacity for regeneration, offering hope for age-related conditions [4].

Improves the function of vital organs

FOXO4-DRI holds significant potential in improving organ function, including the kidneys, by targeting harmful senescent cells. These cells, which accumulate with age or stress, contribute to organ dysfunction by promoting chronic inflammation and impairing tissue repair. FOXO4-DRI works by disrupting the interaction between the FOXO4 protein and p53, enabling p53 to activate apoptosis in senescent cells. This selective removal reduces inflammation and allows for the restoration of healthy tissue [5]. For the kidneys, this means improved filtration efficiency, reduced scarring, and enhanced regenerative capacity, offering hope for managing conditions like chronic kidney disease and mitigating age-related organ decline [6].

Furthermore, by targeting and eliminating senescent cells, which accumulate with age and contribute to inflammation and tissue dysfunction, FOXO4-DRI could help improve cardiac health for those suffering with heart disease. Research suggests that senescent cells impair proteasome activity in the heart, leading to the accumulation of damaged proteins and reduced cardiac function. FOXO4-DRI may enhance the heart’s natural repair processes by promoting autophagy and proteasome function, reducing oxidative stress, and improving tissue regeneration. These effects could potentially mitigate age-related cardiac decline and support overall heart health, though further studies are needed to confirm these benefits in humans.

Reduces chronic inflammation

FOXO4-DRI reduces chronic inflammation by targeting and eliminating senescent cells, which are known to be major contributors to inflammation in the body. These senescent cells release harmful pro-inflammatory signals, known as the senescence-associated secretory phenotype (SASP), that damage surrounding tissues and disrupt overall organ function. By clearing out senescent cells, FOXO4-DRI decreases the production of inflammatory signals, promotes tissue repair, and restores a healthier cellular environment, effectively reducing chronic inflammation and its negative effects on the body [7].

Supports hair regrowth

FOXO4-DRI shows promise in supporting hair regrowth by addressing the root causes of hair loss at the cellular level. An accumulation of senescent cells in aging tissues, contribute to inflammation and disrupt the healthy functioning of hair follicles. FOXO4-DRI reduces inflammation and restores a healthier environment in scalp tissues. This allows hair follicles to regenerate and function optimally, promoting thicker, healthier hair growth and providing a potential breakthrough for age or stress-related hair loss.

Provides neuroprotection

FOXO4-DRI shows potential as a neuroprotective agent by targeting senescent cells that contribute to neuroinflammation and cognitive decline. These damaged cells release harmful inflammatory signals, disrupting the delicate environment needed for healthy brain function. By clearing senescent cells out, FOXO4-DRI reduces neuroinflammation and mitigates the stress on surrounding neurons. This creates a healthier cellular environment that supports neuronal repair, synaptic health, and overall brain function. Such effects could offer new hope for preventing or slowing neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease [1].

Buy FOXO4-DRI Pre-Mixed Peptide Pen for research use from PharmaLabGlobal. Buy Peptide Pen kits and pre-mixed refill cartridges for research purposes.

Buy FOXO4-DRI Nasal Spray Peptide  30ml from PharmaLabGlobal

Is FOXO4-DRI part of the fork head peptide family?

Yes, FOXO4-DRI is related to the forkhead peptide family. Specifically, it is derived from the FOXO (Forkhead box O) family of transcription factors, which are part of the larger forkhead family. These transcription factors play a critical role in regulating various cellular processes, including apoptosis (programmed cell death), oxidative stress response, and cell cycle regulation.

FOXO4, one of the members of this family, interacts with the p53 protein to help senescent cells avoid apoptosis. FOXO4-DRI is a modified version of this interaction domain, designed to disrupt the FOXO4-p53 binding. This disruption allows senescent cells to undergo apoptosis, making FOXO4-DRI a promising senolytic agent for anti-aging and therapeutic applications.

What is peptide synthesis?

Peptide synthesis is the process of creating peptides, which are short chains of amino acids linked by peptide bonds. These chains are the building blocks of proteins and play crucial roles in biological processes, such as signaling, immune responses, and tissue repair. 

Could FOXO4-DRI act as a tumour suppressor?

FOXO4-DRI has potential as a tumor suppressor due to its ability to target and eliminate senescent cells, which are often associated with a pro-inflammatory environment that can promote tumor growth. Senescent cells secrete factors known as the senescence-associated secretory phenotype (SASP), which can contribute to chronic inflammation and create a microenvironment favorable for cancer progression.

By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects. This mechanism could theoretically help suppress tumor development by removing cells that might otherwise contribute to a cancer-friendly environment. However, while preclinical studies show promise, more research is needed to fully understand its role and efficacy as a tumor suppressor in humans.

What peptides could FOXO4-DRI be stacked with?

FOXO4-DRI could potentially be stacked with other peptides that complement its senolytic (senescent cell-clearing) properties to enhance overall health and anti-aging effects. Here are some examples:

  1. Epitalon: Known for its anti-aging properties, the Epitalon peptide promotes telomere lengthening and supports cellular repair, which could synergize with FOXO4-DRI’s senescent cell-clearing effects.

  2. Thymosin Alpha-1 (Tα1): This peptide boosts immune function and reduces inflammation, which could work well alongside FOXO4-DRI to improve the body’s response to aging and chronic conditions. Buy Thymosin Alpha-1.

  3. BPC-157: A peptide known for its regenerative properties, the BPC-157 peptide could complement FOXO4-DRI by promoting tissue repair and healing, especially in areas affected by senescent cell accumulation.

  4. GHK-Cu: This copper peptide supports skin regeneration, wound healing, and anti-inflammatory effects, making it a good partner for FOXO4-DRI in anti-aging protocols.

  5. CJC-1295/Ipamorelin: These growth hormone-releasing peptides could enhance tissue repair and regeneration, potentially amplifying the rejuvenating effects of FOXO4-DRI.

  6. NAD+ Boosters (e.g., NMN or NR): While not peptides, NAD+ precursors can be stacked with FOXO4-DRI to support mitochondrial function and cellular energy, complementing its senolytic action.

When considering peptide stacks, it’s crucial to consult with a healthcare professional or researcher experienced in peptide therapies to ensure safety, proper dosing, and compatibility. Most of these peptides are still in the research phase and not approved for human use. PharmaLabGlobal supplies peptides to the research industry only, with worldwide shipping.

Scientific Research

[1] Al-Naggar IMA, Kuchel GA, Xu M. Senolytics: targeting senescent cells for age-associated diseases. Curr Mol Biol Rep. 2020 Dec;6(4):161-172. doi: 10.1007/s40610-020-00140-1.

[2] Bourgeois B, Madl T. Regulation of cellular senescence via the FOXO4-p53 axis. FEBS Lett. 2018 Jun;592(12):2083-2097.

[3] Zhang C, Xie Y, Chen H, Lv L, Yao J, Zhang M, Xia K, Feng X, Li Y, Liang X, Sun X, Deng C, Liu G. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY). 2020 Jan 20;12(2):1272-1284.

[4] Lucía Antelo-Iglesias, Pilar Picallos-Rabina, Valentín Estévez-Souto, Sabela Da Silva-Álvarez, Manuel Collado, The role of cellular senescence in tissue repair and regeneration, Mechanisms of Ageing and Development, Volume 198, 2021.

[5] Tan H, Xu J, Liu Y. Ageing, cellular senescence and chronic kidney disease: experimental evidence. Curr Opin Nephrol Hypertens. 2022 May 1;31(3):235-243.

[6] Xu J, Zhou L, Liu Y. Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies. Front Pharmacol. 2020 Dec 11;11:601325.

[7] Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Commun Biol. 2025 Feb 24;8(1):299.

Further Reading:

Unlocking the Fountain of Youth: Exploring the FOXO4-DRI Nasal Spray

This blog highlights how the spray targets and eliminates senescent cells, which contribute to aging and inflammation. By doing so, it may reverse aging effects, improve tissue regeneration, enhance cognitive function, and promote overall longevity. The blog also discusses preclinical studies showing benefits like reduced chemotherapy damage, improved organ function, and potential neuroprotection. 

Exploring Age-Related Testosterone Insufficiency

Explore the potential of peptides like FOXO4-DRI in addressing testosterone insufficiency, particularly in aging men. FOXO4-DRI targets senescent cells, which disrupt natural testosterone production, potentially restoring hormonal balance. Other peptides, such as HCG, Triptorelin, and Gonadorelin, are also explored for their ability to stimulate the body’s natural testosterone production by enhancing hormonal signalling. 

Can FOXO4-DRI Treat Pulmonary Fibrosis?

Discover the promising role of FOXO4-DRI in the treatment of pulmonary fibrosis, a severe lung disease marked by scarring and tissue stiffness. FOXO4-DRI targets senescent cells, which contribute to inflammation and fibrosis, by inducing their apoptosis, thereby reducing lung damage. Early animal studies suggest its potential to slow or reverse fibrosis, offering hope for more effective treatments. While still in the research phase and untested in humans, FOXO4-DRI represents a groundbreaking approach to addressing pulmonary fibrosis.

Buy FOXO4-DRI from PharmaLabGlobal

Premium Quality Peptides

Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)

Global Supplier

At Pharma Lab Global we supply premium peptides to the research industry worldwide.

Excellent Customer Service

Our mission and priority are to ensure that clients receive a superior customer experience.

Competitive Prices

At Pharma Lab Global we aim to supply the highest purity research peptides at affordable prices.

ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY

DISCLAIMER: All products sold by Pharma Lab Global are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.