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GDF-8 Myostatin Nasal Spray
£97.43 – £189.86 This product has multiple variants. The options may be chosen on the product page -
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GDF-8 Pre-Mixed Pen 1mg
£94.31 – £254.63 This product has multiple variants. The options may be chosen on the product page -
GDF-8 (Myostatin)
£89.43 – £98.41 This product has multiple variants. The options may be chosen on the product page
What is GDF-8 Myostatin
GDF-8, commonly known as Myostatin, is a protein that plays a crucial role in regulating muscle growth. It belongs to the transforming growth factor-beta (TGF-β) family and acts as a growth differentiation factor [1].
The signal peptide Myostatin primarily functions by inhibiting muscle cell development and preventing excessive skeletal muscle growth, ensuring balanced tissue regulation. Mutations or reduced activity of Myostatin can lead to significant increases in muscle mass, a phenomenon observed in certain animals and rare human conditions [2]. This has sparked interest in Myostatin research for potential applications in treating muscle-wasting disorders, improving athletic performance, and exploring its therapeutic possibilities in regenerative medicine.
Potential Benefits of GDF-8
- Studies have suggested that GDF-8 Myostatin could have the following potential benefits:
- Promotes controlled muscle growth
- Improves recovery times
- May accelerate muscle repair and recovery
- Potential treatment for muscle wasting disorders.
Buy GDF-8 Myostatin Peptide Vial here for research use – Available in 1mg peptide vials.
Mechanism of Action of GDF-8 Myostatin
GDF-8, commonly referred to as Myostatin, is a critical protein in the regulation of muscle growth. It functions as a growth differentiation factor within the TGF-β (transforming growth factor-beta) superfamily. Myostatin’s primary role is to inhibit muscle cell proliferation and differentiation, maintaining balanced skeletal muscle mass in the body [3].
Myostatin protein exerts its effects by binding to specific receptors on the surface of muscle cells, primarily Activin receptor type IIB (ActRIIB). Once bound, this interaction activates a cascade of intracellular signalling pathways, particularly the Smad proteins. Upon activation, Smad2 and Smad3 proteins form a complex with Smad4, which then translocates to the nucleus. This complex regulates the expression of genes associated with muscle growth inhibition [4].
By controlling these genetic pathways, Myostatin effectively suppresses muscle cell (myoblast) proliferation and differentiation into mature muscle fibers. Its activity prevents unchecked muscle expansion, ensuring tissue culture homeostasis.
Disruptions in Myostatin activity, such as gene mutations or functional blockade, result in increased muscle growth and hypertrophy. This has made Myostatin a focus of intense research, with potential therapeutic applications in addressing muscle-wasting disorders such as muscular dystrophy and age-related sarcopenia [5].
GDF-8 Myostatin is available in 15 ml or 30ml Peptide Nasal Spray.
Potential Clinical Applications of GDF-8 Myostatin
Studies investigating GDF-8 Myostatin have identified it could have the following applications:
Lean Muscle Mass Growth
GDF-8, or Myostatin, plays a vital role in promoting controlled muscle growth by regulating muscle cell proliferation and differentiation. Acting as a growth differentiation factor, it ensures that muscle growth doesn’t exceed necessary limits, maintaining balance and tissue homeostasis. By binding to Activin receptor type IIB (ActRIIB) on muscle cells, Myostatin activates signaling pathways that suppress excess myoblast (muscle cell precursor) development. This prevents unchecked muscle expansion and helps maintain structural integrity [3]. Myostatin’s precise regulation is crucial, as it ensures muscles develop optimally without overgrowth, supporting healthy functionality while protecting against potential complications of excessive muscle hypertrophy.
Promotes Muscle Repair and Recovery After Injury
Clinical studies have found that GDF-8, or Myostatin, contributes to muscle repair and recovery by regulating muscle growth during the healing process. It ensures a balanced response, preventing excessive cell proliferation that could lead to scarring or fibrosis, which may impair muscle functionality [6]. By controlling the activation and differentiation of muscle precursor cells (myoblasts), Myostatin supports tissue regeneration in an orderly manner. Its precise modulation aids in optimal recovery, enhancing muscle strength and structure after injury. Researchers are exploring its therapeutic potential to improve outcomes for individuals recovering from muscle injuries or conditions like muscular dystrophy, offering hope for better restoration of muscle function.
Reduces Exercise Recovery Time
GDF-8 peptide can play an important role in lowering exercise recovery times by promoting a balanced muscle repair process and efficient regeneration. During exercise, muscle fibres experience micro-tears that need repair for growth and recovery. Myostatin helps regulate this process by controlling the activation and differentiation of muscle precursor cells, or myoblasts [7]. By ensuring a balanced repair process, Myostatin prevents excessive proliferation, which could lead to scarring or fibrosis that might impair muscle function.
Additionally, scientists have found that. Myostatin can help reduce inflammation—a key factor in post-exercise soreness and recovery time. Controlled inflammation allows the body to efficiently clear damaged tissue and begin the rebuilding process without prolonging recovery. This balance is crucial for restoring muscle functionality and strength more quickly.
Myostatin’s regulation of muscle growth also ensures that repair occurs in an organized and efficient manner, preventing overgrowth while maintaining structural integrity. Together, these effects optimize the recovery process, minimizing downtime after strenuous exercise while supporting healthy muscle performance.
Potential Treatment for Muscle Wasting Diseases
By inhibiting Myostatin, the pathway for muscle precursor cells (myoblasts) to proliferate and differentiate into mature muscle tissue becomes more accessible. This can significantly enhance muscle regeneration, promoting the replacement of damaged or lost muscle. Additionally, suppressing Myostatin’s activity helps prevent further muscle atrophy, stabilizing muscle mass over time.
This therapeutic potential is particularly impactful in conditions like cachexia, often associated with cancer or chronic diseases, where muscle loss drastically reduces quality of life. Similarly, in sarcopenia, which affects aging populations, Myostatin inhibition may help restore strength and mobility. The focus on Myostatin-based treatments continues to grow as it holds significant hope for improving outcomes and quality of life for patients with muscle-wasting diseases [8].
Buy GDF-8 Myostatin Pre-Mixed Peptide Pen. Peptide pen kits and pre-mixed refill cartridges offer a convenient way to research peptides without peptide reconstitution. Please note all products sold by PharmaLabGlobal are for laboratory research purposes only.
What are the potential side effects of GDF-8 Myostatin peptide?
Inhibiting GDF-8 Myostatin can lead to excessive muscle growth, which may strain joints, tendons, and ligaments, increasing the risk of injuries. It may also impair fat metabolism, disrupting energy balance and body composition. Cardiovascular risks could arise due to the added strain on the heart from extreme muscle mass. Additionally, tendon and ligament health might not keep pace with muscle growth, leading to imbalances. Long-term effects remain uncertain, as Myostatin plays a role in overall body regulation, potentially affecting immune response, hormonal balance, and organ function. Professional guidance is essential when considering its use.
GDF-8 Myostatin FAQ's
What is a recombinant protein?
A recombinant protein is a protein that has been artificially created through genetic engineering. This process involves taking a specific gene that encodes the desired protein and inserting it into the DNA of a host organism, such as bacteria, yeast, or mammalian cells. The host organism is then cultured in a lab, where it produces the protein as part of its natural biological processes.
Is Myostatin a mature protein?
GDF-8, commonly known as Myostatin, is not initially a mature protein. It is first produced in the body as an inactive precursor called a propeptide. For Myostatin to become biologically active, this precursor must undergo a process called proteolytic cleavage. This step removes the inhibitory propeptide, releasing the mature and active form of Myostatin.
Once activated, Myostatin plays a critical role in muscle growth regulation. It functions as a negative regulator, meaning it limits the growth and proliferation of muscle cells. By doing so, Myostatin helps maintain a balance in muscle development, preventing excessive growth.
This regulation is significant because mutations or disruptions in Myostatin activity can lead to abnormal muscle growth. For example, animals or humans with reduced or blocked Myostatin activity often exhibit increased muscle mass for example in Belgian blue cattle. This characteristic has made Myostatin a popular subject of research for potential therapeutic applications, including treatments for muscle-wasting conditions like muscular dystrophy or age-related muscle loss.
Scientific Research
[1] Elkasrawy MN, Hamrick MW. Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):56-63.
[2] Amthor H, Macharia R, Navarrete R, Schuelke M, Brown SC, et al. Lack of myostatin results in excessive muscle growth but impaired force generation. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1835-40.
[3] Elkina Y, von Haehling S, Anker SD, Springer J. The role of myostatin in muscle wasting: an overview. J Cachexia Sarcopenia Muscle. 2011 Sep;2(3):143-151.
[4] Rodgers BD, Ward CW. Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs. Endocr Rev. 2022 Mar 9;43(2):329-365.
[5] Baczek J, Silkiewicz M, Wojszel ZB. Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps. Nutrients. 2020 Aug 11;12(8):2401.
[6] Hamrick MW, Arounleut P, Kellum E, Cain M, Immel D, Liang LF. Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury. J Trauma. 2010 Sep;69(3):579-83.
[7] Chen MM, Zhao YP, Zhao Y, Deng SL, Yu K. Regulation of Myostatin on the Growth and Development of Skeletal Muscle. Front Cell Dev Biol. 2021 Dec 24;9:785712.
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