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Humanin Pre-Mixed Pen 10mg
$90.70 – $244.91 This product has multiple variants. The options may be chosen on the product page -
Humanin
$42.97 – $59.44 This product has multiple variants. The options may be chosen on the product page -
Humanin Nasal Spray
$86.89 – $164.71 This product has multiple variants. The options may be chosen on the product page
What is Humanin?
Humanin is a mitochondrial-derived peptide encoded by the 16S rRNA within mitochondrial DNA. This 24-amino-acid peptide offers significant neuroprotective and cytoprotective benefits.
Initially discovered for its ability to counteract Alzheimer’s-related cellular toxicity, Humanin has since been recognized for its broader anti-apoptotic properties. It binds to specific receptors, such as the CNTFR/WSX-1/gp130 complex, activating pathways like JAK/STAT to defend against oxidative stress and cellular damage [1].
Humanin also modulates insulin-like growth factor (IGF-I) signalling, enhancing metabolic functions. Its levels decline with age, correlating with conditions such as Alzheimer’s and cardiovascular diseases, positioning Humanin as a promising target for combating aging and chronic disease [2].
Molecular Formula: C121H205F3N34O34S2
Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser- Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp- Leu-Pro-Val-Lys-Arg-Arg-Ala
Potential Benefits of Humanin
- Clinical studies investigating Humanin have found that it could have the following potential benefits:
- Safeguards neurons from amyloid-beta toxicity, reducing the risk of Alzheimer’s disease.
- Protects cells from oxidative stress and damage caused by harmful stimuli.
- Blocks cell death by interacting with apoptosis-inducing proteins like Bax.
- Modulates insulin-like growth factor (IGF-I) signaling, supporting better glucose metabolism and energy balance.
- May lower risks associated with cardiovascular diseases.
Buy Humanin Peptide Vial here – Available in high purity 10mg peptide vials for research use.
When purchasing research peptide vials, you will also require Bacteriostatic Water and research supplies for peptide reconstitution.
Mechanism of Action of Humanin
Research professionals have demonstrated that the Humanin peptide operates as a mitochondrial-derived molecule with exceptional protective properties. Its mechanism of action involves binding to specific cell surface receptors like the CNTFR/WSX-1/gp130 complex, which activates crucial signalling pathways, including the JAK/STAT and ERK1/2 systems. These pathways bolster cellular defenses by reducing oxidative stress, preventing apoptotic signals, and enhancing survival mechanisms [1].
Humanin also interacts with pro-apoptotic proteins, such as Bax, neutralizing their activity and guarding cells against programmed death. Furthermore, this peptide influences insulin-like growth factor (IGF-I) signalling, modulating energy metabolism and improving glucose regulation.
These multifaceted actions make Humanin highly neuroprotective, safeguarding neurons against amyloid-beta toxicity associated with Alzheimer’s disease. It mitigates cellular damage linked to oxidative stress, a significant factor in aging and age-related diseases, including cardiovascular conditions [3]. By strengthening metabolic functions, reducing inflammation, and protecting cells, Humanin presents a promising therapeutic candidate for enhancing health span and combating neurodegeneration and chronic illness.
Buy Humanin Nasal Spray from PharmaLabGlobal offering a painless, nasal delivery to your clinical research.
Future Clinical Applications of Humanin
Through research development the following areas of potential applications of Humanin have been identified as:
Neuroprotective Properties
Humanin peptide exhibits strong neuroprotective properties through several mechanisms. It counteracts amyloid-beta toxicity, a major contributor to Alzheimer’s disease, by binding to cellular receptors such as the CNTFR/WSX-1/gp130 complex. This interaction activates protective pathways like JAK/STAT and ERK1/2, which fortify nerve cells against oxidative stress and inflammation. Additionally, Humanin interacts with pro-apoptotic proteins like Bax, inhibiting their function and preventing neuronal death. By reducing cellular stress and preserving neural integrity, Humanin offers significant potential for preventing or mitigating neurodegenerative diseases, making it a promising candidate for future therapies targeting cognitive decline and conditions like Alzheimer’s [4].
Cytoprotective Effects
Humanin peptide has remarkable cytoprotective effects, primarily through its ability to combat oxidative stress and inhibit apoptosis. Oxidative stress, a key driver of cellular damage and aging, is mitigated by Humanin as it activates protective cellular pathways like JAK/STAT and ERK1/2. These signalling pathways enhance cellular resilience, reduce inflammation, and strengthen antioxidant defenses.
Additionally, Humanin interacts directly with pro-apoptotic proteins such as Bax, effectively blocking their activity and preventing programmed cell death. This action safeguards cells from harmful stimuli and ensures their survival under stress [5].
Through these mechanisms, Humanin preserves cellular integrity, reducing damage associated with aging and chronic diseases. Its cytoprotective properties hold significant promise for developing therapies aimed at extending healthspan and combating conditions like cardiovascular disease and neurodegeneration.
Improved Metabolic Function
Humanin peptide improves metabolic health through its multifaceted effects on insulin sensitivity, glucose metabolism, and inflammation. By influencing the insulin-like growth factor (IGF-I) signaling pathway, Humanin enhances the body’s ability to regulate blood sugar levels, improving insulin sensitivity and reducing the risk of insulin resistance. This makes it particularly beneficial for conditions like type 2 diabetes [6].
Additionally, Humanin combats chronic inflammation, a major contributor to metabolic syndrome and other related health issues. Its activation of protective pathways, such as JAK/STAT, helps reduce inflammatory markers and oxidative stress, contributing to overall metabolic function.
These combined effects make Humanin a promising candidate for therapies targeting metabolic disorders, offering potential improvements in glucose regulation and reduced risk of chronic diseases like diabetes and cardiovascular conditions [7]. Its ability to address underlying metabolic dysfunction highlights its therapeutic potential for enhancing both health span and metabolic resilience.
Supports Cardiovascular Health
Humanin peptide supports cardiovascular health by addressing key factors that contribute to heart disease. It reduces oxidative stress, which plays a major role in damaging blood vessels and promoting conditions like atherosclerosis. Through its activation of pathways like JAK/STAT, Humanin enhances antioxidant defenses and reduces cellular damage, promoting vascular integrity [7].
Additionally, Humanin improves endothelial function by protecting the inner lining of blood vessels. This helps maintain proper blood flow, reduces inflammation, and prevents arterial stiffness. Its ability to counteract pro-apoptotic proteins and inflammation further fortifies cardiovascular resilience.
By mitigating oxidative stress, improving endothelial health, and protecting against plaque buildup (atherosclerosis), Humanin shows substantial potential in preventing cardiovascular diseases such as heart attacks and strokes [8]. These combined effects make it a promising molecule for therapies aimed at promoting overall heart health and combating related chronic conditions.
Buy Humanin Pre-Mixed Peptide Pen. Peptide Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal are a convenient way of researching peptides.
Scientific Research
[1] Yen K, Lee C, Mehta H, Cohen P. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Jan 11;50(1):R11-9.
[2] Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct;13(5):958-61.
[3] Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 Jun 23;12(12):11185-11199.
[4] Niikura T. Humanin and Alzheimer’s disease: The beginning of a new field. Biochim Biophys Acta Gen Subj. 2022 Jan;1866(1):130024.
[5] Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait AC, Reed JC. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61.
[6] Kuliawat R, Klein L, Gong Z, Nicoletta-Gentile M, Nemkal A, Cui L, Bastie C, Su K, Huffman D, Surana M, Barzilai N, Fleischer N, Muzumdar R. Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J. 2013 Dec;27(12):4890-8.
[7] Rochette L, Meloux A, Zeller M, Cottin Y, Vergely C. Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders. Arch Cardiovasc Dis. 2020 Aug-Sep;113(8-9):564-571.
[8] Xu X, Chua CC, Gao J, Hamdy RC, Chua BH. Humanin is a novel neuroprotective agent against stroke. Stroke. 2006 Oct;37(10):2613-9
Further Reading:
Humanin Peptide: Exploring its Therapeutic Potential for Age-Related Diseases
The blog explores the potential of Humanin peptide in combating age-related diseases like Alzheimer’s, Parkinson’s, and cardiovascular conditions. It highlights Humanin’s role in protecting mitochondria, reducing oxidative stress, and preventing cellular damage, which are key contributors to aging. The peptide shows promise in improving mitochondrial function, enhancing antioxidant production, and protecting neurons from damage, potentially slowing cognitive decline and reducing beta-amyloid plaques in Alzheimer’s. Additionally, it may support heart health by reducing inflammation and improving vascular function.
Unveiling the Protective Power of NAD+ Against Alzheimer’s Disease
Delve into the potential of NAD+ and peptides like Humanin and P-21 in combating Alzheimer’s disease. It highlights NAD+ as a critical molecule for mitochondrial function, oxidative stress reduction, and neuronal resilience, which are vital in slowing cognitive decline. Humanin is noted for its neuroprotective properties, including reducing beta-amyloid toxicity and improving brain insulin sensitivity. P-21 is explored for its role in promoting neurogenesis and reducing tau pathology. Together, these compounds show promise in addressing Alzheimer’s through mitochondrial health, neuroprotection, and cognitive regeneration, offering hope for future therapeutic strategies.
How Humanin Peptide Supports Neuroprotection?
We highlight the neuroprotective potential of Humanin, a mitochondrial-derived peptide, in combating neurodegenerative diseases like Alzheimer’s and Parkinson’s. Humanin works by stabilizing mitochondrial function, reducing oxidative stress, and preventing cell death, which are critical in preserving brain health. It also helps mitigate inflammation and supports cellular repair processes, making it a promising candidate for slowing cognitive decline. The blog further explores the synergistic benefits of combining Humanin with NAD, another molecule that enhances mitochondrial energy production and DNA repair, offering a comprehensive approach to neuroprotection and the prevention of age-related brain disorders.
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