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IGF-1 LR3 Nasal Spray
£87.94 – £170.88 This product has multiple variants. The options may be chosen on the product page -
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IGF-1 LR3 Pre-Mixed Pen 1mg
£82.52 – £222.80 This product has multiple variants. The options may be chosen on the product page -
IGF-1 LR3
£20.42 – £88.92 This product has multiple variants. The options may be chosen on the product page
Buy IGF-1 LR3
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a modified peptide designed to amplify growth and recovery. With an extended half-life and enhanced bioavailability, it remains active in the body longer, ensuring prolonged effects [1].
Known for its potent muscle-building capabilities, IGF-1 LR3 promotes protein synthesis, accelerates recovery, and prevents muscle breakdown. It also supports fat loss by boosting metabolic rate and targeting visceral fat, improving body composition [2]. Beyond fitness, IGF-1 LR3 aids in anti-aging through tissue repair, collagen production, and cellular regeneration. Its ability to enhance energy, cognitive function, and vitality makes it a versatile peptide.
Molecular Formula: C400H625N111O115S9
Amino Acid Sequence: MFPAMPLSSLFVNGPRT LCGAELVDALQFV CGDRGFYFNKPTGYGSSSRRAPQT GIVDECCFRSCDLRRLEMYCAP LKPAKSA
View the HPLC Certificate here.
Potential Benefits of IGF-1 LR3
- Clinical studies have suggested that supplementation with IGF-1 LR3 could have the following benefits:
- Enhanced Muscle Growth and Recovery
- Fat Loss and Lean Body Composition
- Anti-Aging and Cellular Regeneration
- Bone Health and Joint Support
- Improved Cognitive Function and Mood
- Enhanced Immune System Function
- Promotes Better Cardiovascular Health
- Enhances Muscle Hyperplasia and Repair
Buy IGF-1 LR3 Peptide Vial here – Available in 0.1mg and 1 mg dosages.
Mechanism of Action of IGF-1 LR3
IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arginine 3) works by binding to IGF-1 receptors located on muscle cells, initiating signalling pathways that drive protein synthesis while inhibiting protein breakdown. This dual action boosts muscle growth and repair, making it an effective aid in building lean mass from physical activity [3].
IGF-1 LR3 also stimulates the proliferation and differentiation of satellite cells, which are essential for repairing damaged muscle tissue and supporting the development of new muscle fibers.
Its role in fat metabolism is significant, as it enhances the metabolic rate and promotes the breakdown of stored fat, particularly visceral fat. Unlike regular IGF-1, IGF-1 LR3 has an extended half-life, which prevents rapid degradation and allows it to remain active in the body longer [4]. This increases its bioavailability and ensures sustained interaction with target cells, optimizing its effects on muscle growth, body weight loss, and overall tissue regeneration.
Buy IGF-1 LR3 Nasal Spray from PharmaLabGlobal offering a non-invasive, peptide nasal delivery to your clinical research. Research peptide nasal sprays are available in 15 ml or 30 ml bottles, with convenient product packaging for laboratory research purposes.
Areas of IGF-1 LR3 Research
Clinical studies have identified that IGF-1 LR3 could have the following applications with further research:
Supports Muscle Growth and Repair
IGF-1 LR3 can play a crucial role in muscle growth and recovery by promoting protein synthesis, a critical process for building and repairing muscle tissue. It activates satellite cells, which are essential for muscle repair and the development of new muscle fibers after exercise or injury. Additionally, IGF-1 LR3 inhibits protein breakdown, preserving muscle mass during periods of intense training or caloric deficits [3]. Its extended half-life ensures prolonged activity, allowing for sustained repair and adaptation.Â
IGF-1 LR3 enhances muscle repair by stimulating protein synthesis, a key process for rebuilding damaged muscle fibers. It promotes cellular regeneration, ensuring that damaged tissues are repaired efficiently and effectively [5]. This growth factor accelerates recovery time, allowing muscles to heal faster after intense exercise or injury. By enhancing the formation of new muscle cells and improving nutrient delivery to tissues, IGF-1 LR3 supports muscle growth alongside repair.
Improves Metabolism Function
Scientists have found that IGF-1 LR3 may boost metabolic rate by enhancing fat metabolism and promoting energy expenditure [3]. It stimulates the breakdown of stored fat, particularly visceral fat, which contributes to a more defined and leaner body composition. By increasing the activity of metabolic pathways, it helps the body utilize fats more efficiently as a source of energy. This not only supports fat loss but also elevates overall energy levels, enabling better physical performance and endurance [6]. IGF-1 LR3’s role in preserving lean muscle while reducing fat further optimizes the metabolic rate, creating an ideal environment for maintaining a leaner body composition.
Anti-aging
IGF-1 LR3 contributes to anti-aging by promoting cellular regeneration and tissue repair, which are essential for maintaining youthful function and appearance. It stimulates collagen production, improving skin elasticity and reducing the appearance of fine lines and wrinkles [7].
Furthermore, by preserving lean muscle mass and preventing age-related muscle loss, IGF-1 LR3 supports a stronger and healthier physique. Additionally, it aids in repairing damaged tissues, enhancing recovery, and maintaining joint and bone health. Its ability to boost energy levels, vitality, and cognitive function further combats the effects of aging, helping individuals feel and perform younger while promoting long-term physical and mental well-being.
Enhances Bone and Joint Health
Preliminary evidence suggests that IGF-1 LR3 supports bone health and joint function by stimulating bone density through increased cellular activity and regeneration. It enhances collagen production, a vital component for maintaining the integrity of cartilage and connective tissues in joints. By encouraging the repair of damaged cartilage, it aids in restoring joint mobility and reducing wear and tear [8].
Studies have found that IGF-1 LR3 also helps lower inflammation in joints, alleviating discomfort and promoting faster recovery after physical strain or injury. These combined effects contribute to stronger bones, healthier joints, and improved mobility, making it an excellent option for long-term structural support and overall joint resilience.
Cognitive Improvement and Neuroprotection
IGF-1 LR3 improves cognitive function by promoting neurogenesis, the creation of new brain cells, which is vital for memory, learning, and overall brain health. It aids in repairing damaged neurons, helping sustain communication between brain cells and enhancing mental clarity [9]. By supporting the regeneration of neural networks, IGF-1 LR3 contributes to improved cognitive performance and adaptability.
Additionally, it has protective effects against age-related cognitive decline, preserving memory and reducing the risk of neurodegenerative conditions. Its ability to boost brain function, along with its impact on energy levels and vitality, makes it a valuable asset for maintaining long-term mental health [10].
Immune System Enhancement
IGF-1 LR3 improves the immune system by promoting cellular regeneration and supporting the production of white blood cells, which are critical for fighting infections [11]. Its ability to reduce inflammation helps maintain a balanced immune response, preventing excessive tissue damage caused by chronic inflammatory conditions. By encouraging faster recovery and repair at the cellular level, IGF-1 LR3 strengthens the body’s natural defence mechanisms, making it more resilient against illnesses. Additionally, it promotes overall vitality, which indirectly supports immune health. These effects combine to enhance the immune system’s efficiency, enabling the body to recover from infections more quickly and resist future threats effectively.
Cardiovascular Health
Laboratory studies have found that IGF-1 LR3 may support heart health by enhancing cardiovascular function and aiding the repair of heart tissues. It promotes blood vessel health, improves blood flow, and assists in reducing inflammation, which can often contribute to heart disease [12]. IGF-1 LR3 stimulates cellular regeneration, helping repair and maintain heart muscle cells and optimizing overall cardiac performance. Additionally, its anti-inflammatory properties protect against damage caused by chronic inflammation, reducing the risk of age-related heart conditions. By boosting vitality and supporting a healthy circulatory system, IGF-1 LR3 plays a critical role in preserving long-term heart health and protecting against cardiovascular challenges
Buy IGF-1 LR3 Pre-Mixed Peptide Kit. Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal are for clinical research use only.
Is there a cancer risk with IGF-1 LR3 supplement?
Researches are investigating a positive association with IGF-1 LR3 supplementation and cell growth and proliferation, which may include cancerous cells. Elevated levels of IGF-1 have been associated with an increased risk of certain cancers, such as breast, prostate cancer, and colorectal cancers, in some studies. This is a risk factor because IGF-1 can enhance the survival and proliferation of malignant cells.
IGF-1 LR3 FAQs
What is the difference between IGF-1 LR3 and MGF peptide?
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) and MGF (Mechano Growth Factor) are both peptides that play roles in muscle growth and repair, but they differ significantly in their structure, function, and applications.
Does IGF-1 LR3 increase growth hormone levels?
No, IGF-1 LR3 does not directly increase growth hormone (GH) levels. Instead, it works downstream of growth hormone in the body’s natural growth and repair processes.
Here’s how it works:
- Growth hormone stimulates the liver to produce IGF-1, which then mediates many of GH’s anabolic effects, such as promoting cell growth, protein synthesis, and tissue repair.
- IGF-1 LR3, being a modified and more potent version of natural IGF-1, mimics these effects but does not influence the secretion of growth hormone itself from the pituitary gland.
In summary, while IGF-1 LR3 amplifies the anabolic and growth-promoting effects typically associated with growth hormone, it does not increase GH levels directly. Instead, it acts as a downstream player in the growth hormone-IGF-1 axis.
Scientific Research
[1] Bailes J, Soloviev M. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules. 2021 Feb 4;11(2):217.Â
[2] Tomas FM, Chandler CS, Coyle P, Bourgeois CS, Burgoyne JL, Rofe AM. Effects of insulin and insulin-like growth factors on protein and energy metabolism in tumour-bearing rats. Biochem J. 1994 Aug 1;301 ( Pt 3)(Pt 3):769-75.
[3] Yoshida T, Delafontaine P. Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy. Cells. 2020 Aug 26;9(9):1970.
[4] Anderson LJ, Tamayose JM, Garcia JM. Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects. Mol Cell Endocrinol. 2018 Mar 15;464:65-74.
[5] Song YH, Song JL, Delafontaine P, Godard MP. The therapeutic potential of IGF-I in skeletal muscle repair. Trends Endocrinol Metab. 2013 Jun;24(6):310-9.
[6] Mason C, Xiao L, Duggan C, Imayama I, Foster-Schubert KE, Kong A, Campbell KL, Wang CY, Alfano CM, Blackburn GL, Pollack M, McTiernan A. Effects of dietary weight loss and exercise on insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in postmenopausal women: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2013 Aug;22(8):1457-63.Â
[7] Noordam R, Gunn DA, Tomlin CC, Maier AB, Griffiths T, Catt SD, Ogden S, Slagboom PE, Westendorp RG, Griffiths CE, van Heemst D, de Craen AJ; Leiden Longevity Study group. Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study. Br J Dermatol. 2013 Mar;168(3):533-8.Â
[8] Locatelli V, Bianchi VE. Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis. Int J Endocrinol. 2014;2014:235060.
[9] Wrigley S, Arafa D, Tropea D. Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging. Front Cell Neurosci. 2017 Feb 1;11:14.
[10] Engel MG, Narayan S, Cui MH, Branch CA, Zhang X, Gandy SE, Ehrlich M, Huffman DM. Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice. J Alzheimers Dis. 2025 Jan;103(1):113-126.Â
[11] Smith TJ. Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev. 2010 Jun;62(2):199-236.
[12] Macvanin M, Gluvic Z, Radovanovic J, Essack M, Gao X, Isenovic ER. New insights on the cardiovascular effects of IGF-1. Front Endocrinol (Lausanne). 2023 Feb 9;14:1142644.
Further Reading:
Do Peptides Show Up on a Drugs Test?
Explore whether peptides, commonly used for fitness and therapeutic purposes, are detectable in drug tests. It explains that detection depends on factors like the type of peptide, testing technology, and regulatory guidelines. While standard drug tests may not identify all peptides, advanced methods like mass spectrometry can detect some. The article highlights the implications for athletes, who must adhere to strict anti-doping rules, and casual fitness enthusiasts, who face fewer concerns.Â
Optimizing Performance with MK-677
Discover the benefits, mechanisms, and uses of MK-677, a compound that stimulates growth hormone and IGF-1 production. It highlights its ability to promote muscle growth, fat loss, improved bone density, enhanced sleep quality, and potential anti-aging effects. By mimicking the hormone ghrelin, MK-677 triggers growth hormone release, aiding recovery and overall well-being. The article also emphasizes the importance of consulting healthcare professionals before use, considering long-term safety and ethical considerations.
From Inhibition to Stimulation: Unravelling the Secrets of GDF-8 Myostatin
GDF-8 Myostatin is a protein regulating muscle growth, and its potential for therapeutic applications. It explains how inhibiting GDF-8 Myostatin can enhance muscle mass, strength, recovery, and bone density while aiding in conditions like muscular dystrophy and sarcopenia. The article also highlights its role in fat metabolism and weight loss, suggesting its broader impact on body composition and health. By targeting GDF-8 Myostatin, researchers aim to develop innovative treatments for muscle-related disorders and performance enhancement.
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