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What is KPV ?

KPV is a tripeptide composed of lysine, proline, and valine with potent anti-inflammatory and antimicrobial properties. Originally derived from the alpha-melanocyte-stimulating hormone (α-MSH), KPV has demonstrated key functions in promoting wound healing, reducing inflammation, and improving skin conditions such as eczema and psoriasis [1]. Its ability to modulate immune responses makes it valuable not only for dermatological applications but also for managing inflammatory bowel diseases like Crohn’s disease or colitis. KPV is commonly administered topically, orally, or via injection, offering flexibility depending on the targeted use.

Research continues to explore its therapeutic potential for broader inflammation-related disorders and immune regulation [2].

Molecular Formula: C16H3oN4O4

Amino Acid Sequence: Lys-Pro-Val

Molecular Weight: 342.43 g/mol

View the KPV HPLC Certificate here.

Source: PubChem

Structure of KPV  from PharmaLabGlobal
KPV-Peptide-Vial

Potential Benefits of KPV

Buy KPV Peptide Vial here – Available in 2mg peptide vials for research use only.

All peptide vials containing lyophilized peptide require peptide reconstitution using Sterile or Bacteriostatic Water – view the full range of research consumables. 

Working Mechanism of KPV

KPV peptide works through a multifaceted mechanism of action, leveraging its anti-inflammatory and antimicrobial properties to deliver therapeutic benefits. Derived from the alpha-melanocyte-stimulating hormone (α-MSH), KPV binds to melanocortin receptors (MCRs), particularly MC-1R and MC-3R, which are located on immune cells such as macrophages and neutrophils. This interaction inhibits the release of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, thereby reducing inflammation at the molecular level [1].

Additionally, KPV demonstrates antimicrobial activity by directly disrupting bacterial cell membranes and reducing microbial adhesion to tissues, which helps prevent infections during wound healing [3]. Its ability to modulate inflammation also reduces oxidative stress, promoting cellular repair and maintaining tissue integrity. The peptide further enhances the healing process by promoting epithelial cell migration and regeneration. These mechanisms collectively make KPV effective for managing conditions like inflammatory bowel disease, skin disorders, and other inflammation-driven health issues [2].

Require a fast acting solution to your research? Buy KPV Nasal Spray – available in 15ml or 30ml Peptide Nasal Sprays

Buy KPV  peptide from PharmaLabGlobal

Future Clinical Applications of KPV

Reduces Inflammation

KPV reduces inflammation by interacting with melanocortin receptors (MCRs), particularly MC-1R and MC-3R, which are found on immune cells like macrophages and neutrophils. When KPV binds to these receptors, it inhibits the production and release of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. These cytokines are key drivers of inflammation in the body. By suppressing their activity, KPV helps to downregulate the inflammatory response [1].

Additionally, KPV reduces oxidative stress, which is often associated with chronic inflammation, and promotes cellular repair. Its ability to modulate immune responses further ensures that inflammation is controlled without compromising the body’s ability to fight infections or heal. This dual action makes KPV particularly effective in managing inflammation-related conditions like skin disorders, inflammatory bowel diseases, and other chronic inflammatory states [2].

Promotes Wound Healing and Tissue Repair

KPV promotes wound repair through several mechanisms that enhance tissue healing and regeneration. It reduces inflammation by inhibiting pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, which can otherwise delay the healing process. By controlling inflammation, KPV creates a more favourable environment for normal tissue repair [3].

Additionally, KPV stimulates epithelial cell migration and proliferation, which are critical steps in closing wounds and regenerating damaged tissue. Its antimicrobial properties also help prevent infections at the wound site, further supporting the healing process.

By reducing oxidative stress and promoting cellular health, KPV ensures that the repair process proceeds efficiently, making it a valuable tool for wound healing, tissue regeneration and scar reduction giving better cosmetic result [3].

Antimicrobial Properties

KPV helps protect against bacterial infections primarily through its antimicrobial properties. It can directly disrupt bacterial cell membranes, impairing their structure and function, which leads to the destruction of the bacteria [4]. Additionally, KPV reduces bacterial adhesion to tissues, making it harder for pathogens to establish infections at wound sites or in inflamed areas including intestinal inflammation.

By modulating the immune response, KPV also prevents excessive inflammation, which can sometimes weaken the body’s natural defenses against infections. This balanced approach allows KPV to support the immune system in fighting off bacteria while promoting healing and reducing the risk of secondary infections. These properties make it particularly useful in managing wounds, skin conditions, and other scenarios where bacterial infections are a concern.

Possible Therapeutic Treatment for Eczema and Psoriasis   

Clinical trials have demonstrated that KPV offers promising benefits for individuals with eczema and psoriasis due to its potent anti-inflammatory, antimicrobial, and skin-healing properties. By inhibiting key inflammatory pathways and reducing cytokines like TNF-alpha, KPV helps alleviate the chronic inflammation driving these conditions. Its antimicrobial effects combat harmful bacteria, such as Staphylococcus aureus, often linked to eczema flare-ups [5].

Additionally, KPV promotes faster wound healing, normalizes skin cell turnover, and relieves symptoms like redness, itching, and dryness. Unlike traditional treatments such as steroids, KPV targets the root causes without severe side effects, making it a safer, more sustainable option for managing these skin conditions.

Reduces Inflammation of the Intestine

KPV, a naturally occurring peptide, offers significant potential for reducing intestinal inflammation through its powerful mechanisms. It inhibits pro-inflammatory pathways, such as NF-κB, effectively calming overactive immune responses of disease conditions. Additionally, experiments in animal models have found that KPV strengthens the gut’s epithelial barrier, helping to prevent harmful substances from causing further irritation. Its antimicrobial properties also combat bacteria and fungi that can worsen inflammation. Together, these actions make KPV a promising option for conditions like inflammatory bowel disease (IBD), which are marked by chronic gut inflammation. By reducing flare-ups and supporting healing, KPV may improve quality of life for those managing these challenging conditions [6].

Buy KPV from Pharma Lab Global website. A trusted supplier of peptides for laboratory use.

KPV BPC-157 Nasal Spray Combo  from PharmaLabGlobal

Buy KPV & BPC-157 Nasal Spray Combo

Combining BPC-157 and KPV peptides could offer enhanced therapeutic benefits, particularly for inflammatory conditions like eczema and psoriasis. BPC-157 is renowned for its exceptional tissue repair and gut healing abilities, supporting faster recovery from skin and internal injuries. Meanwhile, KPV provides powerful anti-inflammatory and antimicrobial effects, alleviating symptoms such as redness, itching, and infections.

Together, these peptides create a complementary approach by simultaneously reducing inflammation, repairing tissue damage, and promoting overall healing. This synergy could make them a valuable treatment option for individuals seeking more comprehensive and natural relief from chronic inflammatory disorders, with fewer side effects than traditional therapies.

Buy KPV & BPC-157 Nasal Spray Combo.

PharmaLabGlobal is one of the best locations to purchase Peptide Combinations for clinical research use.

Frequently Asked Questions about KPV

Can KPV have any adverse effects?

KPV is generally considered safe and well-tolerated, with minimal reported side effects. It is a naturally derived peptide and has been shown in studies to be effective when administered orally, subcutaneously, intravenously, or transdermally. However, as with any compound, there is a potential for interactions with other medications. It is recommended to consult with a qualified healthcare practitioner when using KPV or any peptide therapy.

Is KPV approved for human consumption?

KPV is not approved by the FDA for human consumption. It is categorized as a research peptide, and while it is available for purchase, it is typically labelled for in vitro research purposes only. The FDA has noted a lack of sufficient safety data regarding its efficacy in humans.

Buy KPV Nasal Peptide 30ml  from PharmaLabGlobal

Scientific Research

[1] Pawar K, Kolli CS, Rangari VK, Babu RJ. Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin. J Pharm Sci. 2017 Jul;106(7):1814-1820.

[2] Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640.

[3] Bonfiglio V, Camillieri G, Avitabile T, Leggio GM, Drago F. Effects of the COOH-terminal tripeptide alpha-MSH(11-13) on corneal epithelial wound healing: role of nitric oxide. Exp Eye Res. 2006 Dec;83(6):1366-72.

[4] Duarte-Mata DI, Salinas-Carmona MC. Antimicrobial peptides´ immune modulation role in intracellular bacterial infection. Front Immunol. 2023 Mar 28;14:1119574. 

[5] Luger TA, Brzoska T. alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis. 2007 Nov;66 Suppl 3(Suppl 3):iii52-5.

[6] Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008 Mar;14(3):324-31.

Further Reading:

How Does BPC-157 Reduce Inflammation?

This blog highlights BPC-157’s potential to reduce inflammation by modulating pro-inflammatory cytokines, promoting blood vessel formation, and protecting against oxidative stress. The peptide is also noted for its ability to repair NSAID-induced gut damage, enhance immune system regulation, and support tissue regeneration.

The article compares BPC-157 with other peptides like KPV and TB500, emphasizing its broader systemic effects. 

What is the Best Peptide Combination?

Explore how peptide combinations, such as GHRP-6 with Sermorelin for growth hormone stimulation, TB500 with BPC-157 for tissue repair, and KPV with BPC-157 for inflammation reduction, can create synergistic effects.

These combinations amplify individual peptide benefits, offering improved results in areas like muscle growth, healing, and immune modulation. 

Understanding the Synergistic Effects of KPV and BPC-157 Peptide Combination

This discussion explores the synergistic effects of combining KPV and BPC-157 peptides. 

Together, these peptides amplify each other’s benefits, offering enhanced healing for tissues and organs, improved blood flow, and reduced inflammation. This combination shows promise for treating conditions like inflammatory bowel disease, joint injuries, and central nervous system disorders

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DISCLAIMER: All products sold by Pharma Lab Global are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals