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What is LL-37 Peptide

LL-37 is a naturally occurring antimicrobial peptide derived from the cathelicidin family. It plays an important role in the body’s innate immune system by fighting off harmful bacteria, viruses, and fungi.

Beyond its antimicrobial properties, LL-37 is recognized for its ability to modulate the immune response, reducing excessive inflammation while promoting tissue repair. It is also involved in speeding up wound healing, thanks to its capacity to stimulate new cell growth and combat infections at injury sites.

These versatile functions make LL-37 a promising therapeutic candidate for managing infections, inflammatory conditions, and chronic wounds [1].

Molecular Formula: C205H340N60O53
Amino Acid Sequence: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu -Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg- Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
Molecular Weight: 4493 g/mol

Source: PubChem

LL-37 peptide Structure  PharmaLabGlobal

View the HPLC Certificate here.

LL-37 Cap-18 Peptide Vial 5mg  PharmaLabGlobal

Potential Benefits of LL-37 Peptide

Buy LL-37 Peptide Vial here – Available in 5 mg sterile glass vials, containing lyphollized peptide that requires peptide reconstitution using bacteriostatic water. View the full range of research accessories.

LL-37 Peptide Mechanism of Action

LL-37 peptide operates as a key player in the body’s immune defence system, exhibiting multiple mechanisms of action. Its primary role is antimicrobial; it targets harmful pathogens like bacteria, viruses, and fungi. LL-37 disrupts pathogen membranes, effectively killing them and preventing infections [1].

Additionally, LL-37 modulates the immune system by regulating inflammatory responses. It can suppress excessive inflammation, which helps prevent tissue damage, while still promoting the activation of immune cells to fight infections. This balance is crucial in conditions where the immune response needs to be controlled, such as autoimmune diseases [2].

LL-37 also plays a significant role in wound healing. It stimulates cell proliferation and migration, speeding up tissue repair. By reducing infection risks and fostering the regeneration of damaged tissue, LL-37 accelerates the recovery process. These combined actions make it the host defense peptide a promising therapeutic agent for infections, inflammatory conditions, and chronic wounds, offering broad benefits across healing and immune regulation [3].

Buy LL-37 Peptide Nasal Spray from the PharmaLabGlobal website. Peptide Nasal Sprays offer a painless, peptide delivery via the nasal mucosa.

Buy LL-37 Peptide  from PharmaLabGlobal

Prospective Clinical Applications of LL-37 Peptide

Helps Fight Fungal Infections

LL-37 peptide is a potent antimicrobial agent that plays a critical role in being the first line of defence against fungal infections. It fights fungi by directly targeting their cell membranes. LL-37 disrupts the integrity of these membranes, causing leakage of essential components and ultimately killing the fungal cells. This mechanism is particularly effective against a variety of fungal pathogens, including Candida albicans, a common culprit in human infections.

Beyond its direct antimicrobial action, LL-37 enhances the body’s defence by modulating the immune response. It helps activate immune cells to detect and eliminate fungal infections more effectively. At the same time, it prevents excessive inflammation, which can exacerbate tissue damage and slow down recovery. By striking this delicate balance, LL-37 not only clears infections but also promotes healing of affected tissues.

These dual functions make LL-37 an exciting candidate for therapeutic use against stubborn fungal infections, particularly in cases of drug resistance or chronic immune suppression [4].

Reduces Inflammation and Enhances Wound Healing

LL-37 peptide plays an essential role in reducing inflammation through its immune-modulating properties. It achieves this by balancing immune activity, ensuring an effective response to threats while avoiding excessive inflammatory damage [5].

One key way LL-37 achieves this is by suppressing pro-inflammatory cytokines—molecules that drive inflammation. By inhibiting these cytokines, it prevents overactive immune responses that could harm tissues. Furthermore, LL-37 plays a role in calming hyperactive immune cells, reducing unnecessary inflammation while maintaining defence mechanisms against pathogens.

Another critical function is its ability to promote tissue repair. LL-37 encourages the regeneration of damaged cells and enhances wound healing. By limiting inflammation and concurrently supporting the repair process, it creates an environment where healing can occur faster and more effectively.

This dual action of controlling inflammation and enhancing recovery makes LL-37 a promising therapeutic tool for managing chronic inflammatory conditions and promoting overall tissue health.

May Improve Outcomes for Auto-Immune Diseases

By suppressing pro-inflammatory cytokines, LL-37 reduces the excessive inflammation that often exacerbates tissue damage in chronic and autoimmune diseases. It also calms overly active cells of the immune system, allowing the body to maintain defence mechanisms without further escalating inflammation. This dual action aids in minimizing the cycle of immune overreaction and tissue damage [5].

Additionally, LL-37 promotes tissue repair by encouraging cell proliferation and regeneration. This ability is crucial for recovering from the ongoing damage caused by chronic inflammation or autoimmune responses. Beyond healing, LL-37 may slow disease progression by addressing sites of inflammation at its source while improving the body’s ability to restore and maintain healthy tissues.

Buy LL-37 Peptide Pre-Mixed Pen Kit – Peptide Pen Kits from PharmaLabGlobal offer a convenient solution for in vitro laboratory testing. All peptides from the the PharmaLabGlobal laboratory’s website are for research use only.

Buy Thymosin Alpha-1 VIP LL-37 Peptide Stack  from PharmaLabGlobal

VIP Thymosin Alpha-1 LL-37 Peptide Combo

Combining VIP, LL-37, and Thymosin Alpha-1 peptides creates a powerful synergy for immune modulation, inflammation reduction, and tissue repair.

Vasoactive Intestinal Peptide (VIP) regulates immune responses, preventing overactivation while supporting anti-inflammatory pathways. LL-37 contributes antimicrobial properties, curbing infections, while also calming excessive inflammation and promoting tissue regeneration. Thymosin Alpha-1 enhances immune function by stimulating T-cell activity, strengthening the body’s ability to combat chronic illnesses and infections.

Together, these peptides work to restore immune balance, accelerate healing, and reduce disease progression. This combination holds great promise for managing chronic inflammatory conditions, autoimmune disorders, and difficult-to-treat infections, offering a multi-faceted therapeutic approach.

Buy LL-37 Peptide, VIP and Thymosin Alpha-1 Peptide Combo.

Scientific Research

[1] Pahar B, Madonna S, Das A, Albanesi C, Girolomoni G. Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections. Vaccines (Basel). 2020 Sep 10;8(3):517.

[2] Yang B, Good D, et al. Significance of LL-37 on Immunomodulation and Disease Outcome. Biomed Res Int. 2020 May 16;2020:8349712.

[3] Ramos R, Silva JP, Rodrigues AC, Costa R, Guardão L, Schmitt F, Soares R, Vilanova M, Domingues L, Gama M. Wound healing activity of the human antimicrobial peptide LL37. Peptides. 2011 Jul;32(7):1469-76.

[4] Luo XL, Li JX, Huang HR, Duan JL, Dai RX, Tao RJ, Yang L, Hou JY, Jia XM, Xu JF. LL37 Inhibits Aspergillus fumigatus Infection via Directly Binding to the Fungus and Preventing Excessive Inflammation. Front Immunol. 2019 Feb 20;10:283.

[5] Kahlenberg JM, Kaplan MJ. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol. 2013 Nov 15;191(10):4895-901.

Further Reading:

What is the Role of LL-37 in Inflammatory Skin Conditions?

Explore how LL-37 peptide offers hope for managing inflammatory skin conditions like psoriasis, eczema, acne, and rosacea. This blog highlights LL-37’s dual ability to fight infections and regulate immune responses, addressing both microbial triggers and excessive inflammation. Discover its role in reducing flare-ups, enhancing skin defences, and promoting tissue balance.

Immune Boosting Peptides: Unlocking Their Potential in Scientific Research

Discover how peptides like Thymosin Alpha-1, Thymalin, and the Thymosin LL Stack are advancing immune health research. This blog explores their ability to enhance immune function, stimulate T-cells, and regulate immune responses. Learn about their potential in managing infections, addressing autoimmune diseases, and supporting age-related immune decline.

What Is The Very Best Peptide Stack?

Discover the power of peptide stacks for enhanced research outcomes in muscle growth, fat loss, recovery, and immune support. This blog explores effective combinations like Ipamorelin & CJC-1295 for growth hormone release, BPC157 & TB500 for accelerated healing, and Thymalin & LL37 for boosting immunity. Learn how stacking peptides can achieve targeted goals while maximizing their synergistic effects. Read more to uncover the best peptide stack strategies for your research needs.

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