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Melanotan 1 is a synthetic peptide, also known as Afamelanotide, designed to enhance the skin’s natural pigmentation process. It mimics the action of alpha-melanocyte-stimulating hormone (α-MSH), binding to melanocortin receptors on melanocytes. This triggers melanin production, resulting in a tan-like appearance without the need for sun exposure [1].
By increasing melanin levels, Melanotan 1 provides both aesthetic and protective benefits. It helps achieve a more even skin tone while acting as a natural shield against ultraviolet (UV) radiation. This reduces the risk of sunburn, DNA damage, and other UV-related concerns, making it a valuable option for those seeking a safer, sunless tanning solution.
Molecular Formula:
C78H111N21O19
Amino Acids Sequence: Ac-Ser-Tyr-Ser -Nle-Glu -His-D-Phe-Arg-Trp-Gly-Lys- Pro-Val-NH2
Molecular Weight: 1646.8 g/mol
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Melanotan 1 is a synthetic peptide that mimics the action of alpha-melanocyte-stimulating hormone (α-MSH), a natural hormone responsible for increasing melanin production in the skin. When administered under laboratory conditions, Melanotan 1 binds to melanocortin receptors, specifically MC1R, found on melanocytes, which are the skin’s pigment-producing cells. This interaction triggers a process called melanogenesis, where melanin is produced in higher amounts [1].
Melanin, the pigment that gives skin its colour, serves as a natural barrier against ultraviolet (UV) radiation, absorbing harmful rays and preventing skin damage. By enhancing melanin levels, Melanotan 1 helps protect the skin from UV-induced damage such as sunburn and reduces risks associated with overexposure, including premature aging and skin cancer [2].
Additionally, research professionals have demonstrated that the MT1 peptide provides a tan-like effect without requiring prolonged sun exposure, making it an appealing option for individuals seeking a balanced skin tone while protecting overall skin health.
Melanotan 1 (MT1) is available for research use only.
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The use of Melanotan 1 is still under investigation by scientific researchers and is not yet approved for human consumption as a tanning agent. Clinical studies have suggested it could, with further testing, have the following applications:
Sunless Skin Tanning
Melanotan 1 tans the skin without sun exposure by stimulating the body’s natural pigment production process. This synthetic peptide mimics the action of alpha-melanocyte-stimulating hormone (α-MSH), which is key in regulating melanin production. When Melanotan 1 is introduced into the body, it binds to melanocortin receptors, particularly MC1R, on melanocytes. These are the specialized cells responsible for producing melanin, the pigment that colours the skin, hair, and eyes [1].
This binding activates a process called melanogenesis, prompting the melanocytes to generate and distribute more melanin across the skin. The increase in melanin results in a darker, tanned appearance, similar to the effect of sun exposure but without harmful solar UV radiation, thus why the Melanotropic Peptide is often dubbed a sunless tanning agent. Since melanin is also protective, this process provides a barrier against potential ultraviolet damage, offering both an aesthetic and a functional benefit [2].
Reduces the Risk of UV Damage
Melanotan 1 reduces the risk of UV damage to the skin by enhancing the body’s natural defence mechanism through increased melanin production. Melanin is a pigment produced by melanocytes in the skin, and it plays a critical role in protecting against ultraviolet (UV) radiation. When administered, Melanotan 1 binds to melanocortin receptors (MC1R) on melanocytes, triggering a process called melanogenesis. This stimulates the production and distribution of melanin across the skin [3].
Further research suggests that Melanin creates a natural shield by absorbing and dissipating UV rays, minimizing their penetration into deeper layers of the skin. This prevents DNA damage within skin cells, significantly lowering the risk of conditions such as sunburn, premature aging, and even skin cancer.
Potential Therapeutic Treatment for Skin Conditions
Melanotan 1 shows promise as a therapeutic treatment for vitiligo and photosensitivity disorders due to its ability to stimulate melanin production in the skin. Vitiligo is a condition where pigment-producing cells, or melanocytes, are destroyed, leading to uneven skin pigmentation and white patches. By mimicking alpha-melanocyte-stimulating hormone (α-MSH), Melanotan 1 binds to melanocortin receptors on melanocytes, encouraging melanin production and helping restore a more uniform skin tone. This could improve the appearance of areas affected by vitiligo [4].
For photosensitivity disorders, which make individuals highly sensitive to sunlight and prone to UV-induced damage, Melanotan 1’s role in boosting melanin levels offers protective benefits. Melanin acts as a natural sunscreen, absorbing and neutralizing harmful UV rays before they can damage skin cells. This reduces the risk of sunburn, DNA damage, and other complications associated with these conditions, making Melanotan 1 a potential therapeutic option for enhanced skin protection and improved quality of life [5].
Combining Melanotan 1 and Melanotan 2 peptides may offer complementary benefits, enhancing tanning efficiency and skin protection. Melanotan 1 primarily focuses on stimulating melanin production for a natural, even tan without sun exposure. Melanotan 2, on the other hand, goes a step further by not only boosting melanin but also enhancing the tanning process with added sexual health benefits, such as improved libido.
Together, they could provide a more comprehensive solution for achieving deeper pigmentation while minimizing UV damage risks. This combination may also help address conditions like vitiligo or photosensitivity more effectively, offering both aesthetic and functional improvements.
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What is the difference between Melanotan 1 and Melanotan 2?
Melanotan 1 (MT-1) and Melanotan 2 (MT-2) are synthetic peptides developed to stimulate melanin production, aiding sunless tanning and skin protection. While they share similarities, their differences in mechanisms, uses, and effects are significant.
Melanotan 1 directly mimics alpha-melanocyte-stimulating hormone (α-MSH) by binding to melanocortin-1 receptors in the skin’s melanocytes. This stimulates melanin production, resulting in gradual pigmentation and UV exposure protection.
Melanotan II functions similarly but works across multiple melanocortin receptors (MC1R, MC3R, MC4R), stimulating additional effects beyond tanning of the skin, including appetite suppression and sexual enhancement including libido enhancement.
Does Melanotan 1 have any serious side effects?
Melanotan 1 is generally well-tolerated and has a favorable safety profile, but like any compound, it can have adverse effects. Common reactions include mild skin irritation or redness at the injection site, temporary flushing, and, in rare cases, mild nausea or dizziness. These effects are usually short-lived and resolve on their own.
While rare, there are potential risks associated with its use. Repeated application may lead to uneven pigmentation or darkened moles, especially in individuals with pre-existing skin conditions. Serious adverse effects, such as abnormal mole growth, allergic reactions, or interactions with other medications, are uncommon but possible.
Though severe reactions are rare, the lack of long-term studies makes it important to approach Melanotan 1 with caution. Consulting a healthcare professional before use is advised to minimize risks and ensure safe application, especially for those with pre-existing health concerns.
[1] Dall’Olmo L, Papa N, Surdo NC, Marigo I, Mocellin S. Alpha-melanocyte stimulating hormone (α-MSH): biology, clinical relevance and implication in melanoma. J Transl Med. 2023 Aug 22;21(1):562.
[2] Brenner M, Hearing VJ. The protective role of melanin against UV damage in human skin. Photochem Photobiol. 2008 May-Jun;84(3):539-49.
[3] Mun Y, Kim W, Shin D. Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. Int J Mol Sci. 2023 Jul 29;24(15):12152.
[4] Bellei B, Papaccio F, Picardo M. Regenerative Medicine-Based Treatment for Vitiligo: An Overview. Biomedicines. 2022 Oct 28;10(11):2744.
[5] Böhm M, Robert C, et al. An overview of benefits and risks of chronic melanocortin-1 receptor activation. J Eur Acad Dermatol Venereol. 2025 Jan;39(1):39-51.
Tanning with Peptides
This blog explores the use of peptides, such as Melanotan 1 and Melanotan 2, as a sunless tanning solution. It explains how peptides stimulate melanin production, leading to a natural-looking tan while reducing risks like sunburn and premature aging. The article highlights benefits such as improved skin health, convenience, and cost-effectiveness. It also discusses potential risks, like allergic reactions, and emphasizes consulting a dermatologist before use. Additionally, the blog touches on the research and applications of various peptides, including their protective and aesthetic advantages, while stressing that these products are intended for research purposes only.
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Discuss the potential of peptides like Matrixyl, SNAP-8, and GHK-Cu in combating visible signs of aging. It highlights their roles in boosting collagen production, reducing wrinkles, and enhancing skin hydration and elasticity. The article delves into the science behind peptides, their mechanisms of action, and their ability to strengthen the skin barrier. It also discusses advancements in peptide delivery systems to improve absorption and effectiveness. With ongoing research, these bioactive molecules are positioned as promising tools in skincare, offering innovative solutions for maintaining a youthful and rejuvenated complexion.
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