MOTS-c is a mitochondrial-derived peptide consisting of 16 amino acids, originating from the mitochondrial genome. It plays a crucial role in optimizing energy production and enhancing cellular metabolism, primarily by improving mitochondrial function and glucose uptake in muscle cells. In the future MOTS-c could have the following potential applications:
Decreasing Insulin Resistance
MOTS-c peptide works to decrease insulin resistance by optimizing the way cells respond to insulin, the hormone responsible for regulating blood sugar levels. One of the key actions of MOTS-c is to enhance glucose uptake in muscle cells. It achieves this by promoting the efficiency of glucose transporters, which are proteins that facilitate the entry of glucose into cells. With more glucose being absorbed by muscle cells, there is less circulating glucose in the bloodstream, thereby reducing the need for insulin and improving overall insulin sensitivity [5].
Additionally, MOTS-c influences insulin signalling pathways. It supports the activation of certain pathways that increase the sensitivity of cells to insulin, ensuring that the hormone can efficiently trigger the uptake and utilization of glucose. By improving these pathways, MOTS-c helps maintain stable blood sugar levels and reduces the strain on the pancreas to produce excessive insulin [2].
Improves Energy Levels
In addition to the above, clinical studies have found that MOTS-c peptide improves energy levels by enhancing the function of mitochondria, which are the powerhouses of the cell responsible for producing energy. It boosts ATP production, the primary energy currency of the cell, by optimizing the efficiency of the electron transport chain within mitochondria. This increased ATP production ensures that cells have ample energy to perform their functions effectively [6].
Improves fat loss
MOTS-c peptide improves fat loss by enhancing the body’s metabolic rate and promoting fatty acid oxidation. It increases the efficiency of mitochondria, the cell’s energy centres, which boosts the metabolic processes that convert food into energy rather than storing it as fat [5]. This enhanced metabolic activity means more calories are burned at rest and during physical activity, aiding weight management.
Additionally, MOTS-c promotes fat oxidation, which is the process of breaking down stored fats into fatty acids for energy. This not only helps reduce fat accumulation but also provides a steady energy supply for the body. By improving insulin sensitivity, MOTS-c ensures that glucose is effectively absorbed and utilized by the cells, reducing the need to store excess glucose as fat [6].
Reduces Metabolic Stress
MOTS-c peptide improves metabolic stress by enhancing mitochondrial function, which is crucial for maintaining cellular energy balance. By optimizing the efficiency of mitochondria, MOTS-c supports the production of ATP, reducing the strain on cells during periods of high energy demand [6].
Additionally, MOTS-c plays a role in reducing oxidative stress by enhancing the cell’s antioxidant defences. This reduction in oxidative stress helps protect cells from damage caused by free radicals, thereby improving cellular resilience and function. By ensuring that mitochondria operate efficiently and protecting cells from oxidative damage, MOTS-c contributes to improved metabolic health, allowing the body to better handle stress and maintain energy levels [1].
Enhances Cardiovascular Health
MOTS-c peptide improves cardiovascular health by enhancing endothelial function, which is essential for maintaining the flexibility and health of blood vessels [7]. By supporting the production of nitric oxide, a molecule that helps blood vessels relax, MOTS-c promotes better blood flow and reduces the risk of hypertension. Additionally, MOTS-c helps reduce inflammation, a key factor in the development of cardiovascular diseases, by modulating immune responses and reducing inflammatory markers in the body. This anti-inflammatory effect not only protects blood vessels but also supports overall heart health [5]. Furthermore, MOTS-c can improve lipid profiles by promoting the breakdown of fats and reducing the levels of harmful cholesterol in the bloodstream.
Buy MOTS-c Pre-Mixed Peptide Pen. Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal for research purposes.
