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What is MOTS-c Peptide?

MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids. It originates from the mitochondrial genome, specifically encoded by the 12S rRNA region. Mitochondria, known as the cell’s powerhouses, play a crucial role in energy production, and MOTS-c is integral to this process [1].

This peptide has gained attention in recent studies for its potential health benefits, particularly in metabolic processes. MOTS-c may help decrease insulin resistance, enhance the transport of sugars to muscle cells, and promote fat loss [2]. It also appears to boost energy levels and improve the body’s resistance to metabolic stress. Additionally, research suggests that MOTS-c could alleviate aging-related metabolic disorders, improve cardiovascular health, and enhance physical performance [3]. 

Molecular Formula: C101H152N28O22S2

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular Weight: 2174.64 f/mol

View the HPLC Certificate here.

Source: PubChem

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MOTS-C Peptide Vial 10mg

Summary of MOTS-c Benefits:

Buy MOTS-c Peptide Vial here – Available in 10 mg peptide vial.

MOTS-c Mechanism of Action

Research professionals have found that MOTS-c peptide operates within the intricate machinery of cellular processes, primarily influencing mitochondrial function and energy metabolism. As a mitochondrial-derived peptide, MOTS-c is integral to the mitochondria’s important role of the cell, where it helps optimize energy production. This peptide enhances the efficiency of the electron transport chain, a critical pathway within mitochondria that generates ATP, the primary energy currency of the cell. By boosting ATP production, MOTS-c ensures cells have sufficient energy to perform various biological functions [1].

Moreover, MOTS-c has demonstrated that it plays a pivotal role in regulating insulin sensitivity, which is crucial for maintaining healthy blood sugar levels. It does this by enhancing the transport of glucose into muscle cells, ensuring that sugar is effectively utilized for energy rather than being stored as body fat. This process helps decrease insulin resistance, a common issue in metabolic disorders like type 2 diabetes [4].

Additionally, MOTS-c contributes to improved metabolic health by reducing oxidative stress and enhancing metabolic pathways that favour fat oxidation over fat storage. These actions help in promoting better energy utilization and reducing the risk of metabolic diseases. 

Buy MOTS-c Peptide Nasal Spray Online from PharmaLabGlobal –  offering a set dose of MOTS-c peptide via the nasal mucosa of research subjects.

Buy MOTS-c Peptide

Potential Clinical Applications of MOTS-c Peptide

MOTS-c is a mitochondrial-derived peptide consisting of 16 amino acids, originating from the mitochondrial genome. It plays a crucial role in optimizing energy production and enhancing cellular metabolism, primarily by improving mitochondrial function and glucose uptake in muscle cells. In the future MOTS-c could have the following potential applications:

Decreasing Insulin Resistance

MOTS-c peptide works to decrease insulin resistance by optimizing the way cells respond to insulin, the hormone responsible for regulating blood sugar levels. One of the key actions of MOTS-c is to enhance glucose uptake in muscle cells. It achieves this by promoting the efficiency of glucose transporters, which are proteins that facilitate the entry of glucose into cells. With more glucose being absorbed by muscle cells, there is less circulating glucose in the bloodstream, thereby reducing the need for insulin and improving overall insulin sensitivity [5].

Additionally, MOTS-c influences insulin signalling pathways. It supports the activation of certain pathways that increase the sensitivity of cells to insulin, ensuring that the hormone can efficiently trigger the uptake and utilization of glucose. By improving these pathways, MOTS-c helps maintain stable blood sugar levels and reduces the strain on the pancreas to produce excessive insulin [2].

Improves Energy Levels

In addition to the above, clinical studies have found that MOTS-c peptide improves energy levels by enhancing the function of mitochondria, which are the powerhouses of the cell responsible for producing energy. It boosts ATP production, the primary energy currency of the cell, by optimizing the efficiency of the electron transport chain within mitochondria. This increased ATP production ensures that cells have ample energy to perform their functions effectively [6].

Improves fat loss

MOTS-c peptide improves fat loss by enhancing the body’s metabolic rate and promoting fatty acid oxidation. It increases the efficiency of mitochondria, the cell’s energy centres, which boosts the metabolic processes that convert food into energy rather than storing it as fat [5]. This enhanced metabolic activity means more calories are burned at rest and during physical activity, aiding weight management.

Additionally, MOTS-c promotes fat oxidation, which is the process of breaking down stored fats into fatty acids for energy. This not only helps reduce fat accumulation but also provides a steady energy supply for the body. By improving insulin sensitivity, MOTS-c ensures that glucose is effectively absorbed and utilized by the cells, reducing the need to store excess glucose as fat [6].

Reduces Metabolic Stress

MOTS-c peptide improves metabolic stress by enhancing mitochondrial function, which is crucial for maintaining cellular energy balance. By optimizing the efficiency of mitochondria, MOTS-c supports the production of ATP, reducing the strain on cells during periods of high energy demand [6].

Additionally, MOTS-c plays a role in reducing oxidative stress by enhancing the cell’s antioxidant defences. This reduction in oxidative stress helps protect cells from damage caused by free radicals, thereby improving cellular resilience and function. By ensuring that mitochondria operate efficiently and protecting cells from oxidative damage, MOTS-c contributes to improved metabolic health, allowing the body to better handle stress and maintain energy levels [1]. 

Enhances Cardiovascular Health

MOTS-c peptide improves cardiovascular health by enhancing endothelial function, which is essential for maintaining the flexibility and health of blood vessels [7]. By supporting the production of nitric oxide, a molecule that helps blood vessels relax, MOTS-c promotes better blood flow and reduces the risk of hypertension. Additionally, MOTS-c helps reduce inflammation, a key factor in the development of cardiovascular diseases, by modulating immune responses and reducing inflammatory markers in the body. This anti-inflammatory effect not only protects blood vessels but also supports overall heart health [5]. Furthermore, MOTS-c can improve lipid profiles by promoting the breakdown of fats and reducing the levels of harmful cholesterol in the bloodstream.

Buy MOTS-c Pre-Mixed Peptide Pen. Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal for research purposes.

MOTS-C Nasal Spray Peptide 30ml

Is MOTS-c approved for clinical use?

MOTS-c is not yet approved for clinical use by major regulatory bodies, including the FDA. Its is still undergoing in vitro trials for it’s potential uses and applications before being approved for human consumption. PharmaLabGlobal supplies high purity peptides for clinical research use only.

MOTS-c FAQ's

Can MOTS-c increase skeletal muscle growth and endurance?

MOT-c, a mitochondrial-derived peptide, shows promise in enhancing muscle growth and endurance. Preliminary studies indicate that MOT-c can increase protein expression in skeletal muscles, which is beneficial for muscle growth. It also appears to reduce muscle atrophy signalling by decreasing myostatin expression, which is known to inhibit muscle growth. Additionally, the research community has suggested that MOT-c can improve endurance and speed, and significantly increase lean muscle mass, especially when combined with exercise.

Can MOTS-c slow the aging process?

MOTS-c shows potential as an anti-aging peptide by helping cells adapt to stressors, which may slow cellular aging. It has been reported to improve age-related insulin resistance, alleviate metabolic disorders, and enhance mitochondrial health and efficiency. These effects can combat the decline in energy levels and other age-related issues, suggesting that MOTS-c may contribute to slowing the aging process.

What are the associated side effects of MOTS-c?

Reported side effects of MOTS-c use in clinical studies include increased heart rate and potential impacts on heart function. Additionally, there may be sex-specific effects, with metabolic dysfunction influencing MOTS-c levels more in males than in pre-menopausal females. As with any supplement, it’s important to consult with a healthcare professional before use.

Scientific Research

[1] Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 Oct 9;23(19):11991.

[2] Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 3;21(3):443-54.

[3] Li S, Wang M, Ma J, Pang X, Yuan J, Pan Y, Fu Y, Laher I. MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats. Front Endocrinol (Lausanne). 2022 Mar 17;13:812032.

[4] Kong BS, Lee C, Cho YM. Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases. Diabetes Metab J. 2023 May;47(3):315-324.

[5] Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533.

[6] Wan W, Zhang L, Lin Y, Rao X, Wang X, Hua F, Ying J. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. J Transl Med. 2023 Jan 20;21(1):36.

[7] Yuan J, Wang M, Pan Y, Liang M, Fu Y, Duan Y, Tang M, Laher I, Li S. The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats. Sci Rep. 2021 Oct 11;11(1):20077.

Further Reading:

Unlocking Cellular Energy with Peptides

The blog post delves into the potential of AICAR, a synthetic peptide that enhances cellular energy by mimicking the effects of AMP-activated protein kinase (AMPK), which is vital for energy regulation. It offers significant health benefits, particularly in metabolic function, aiding in the management of diabetes and obesity.

The blog discusses how the AICAR and MOTS-c peptides can reduce insulin sensitivity, underscoring their role in promoting metabolic health, further emphasizing the promising potential of peptide therapies in advancing health and wellness.

The Potential Role of Peptides in Diabetes Management

This blog highlights the promising potential of peptides in revolutionizing diabetes care. It discusses how peptides like MOTS-c, AMPK, AICAR, and FTPP can effectively target metabolic pathways to enhance insulin sensitivity and improve glucose homeostasis. 

Collectively, researchers believe that these peptides could offer new avenues for personalized and effective diabetes therapies as alternatives to traditional treatments, emphasizing the potential for improved metabolic health and better disease management outcomes.

Top Peptides for Weight Loss

This article explores the potential of peptides for weight loss. It discusses peptides such as AOD-9604 that promotes fat breakdown and muscle growth, CJC-1295 which boosts fat metabolism and reduces appetite. MOTS-c, a mitochondrial peptide, improves energy expenditure and fat oxidation, Tesofensine which acts as an appetite suppressant, and FTPP, also known as Adipotide, selectively targets fat cells, promoting their reduction. These peptides work by influencing metabolic pathways to improve fat metabolism and energy use, offering promising avenues for weight management and improved metabolic health.

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