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PEG-MGF, or Pegylated Mechano Growth Factor, is a modified peptide that plays a crucial role in muscle repair and growth. Its pegylation increases its half-life, allowing it to remain active in the body for a longer duration and enhancing its effectiveness.
PEG-MGF stimulates satellite cell activation, a vital process for muscle regeneration, and supports tissue repair following injury or physical stress. By promoting recovery and encouraging new muscle fibre growth, it is particularly useful for those seeking improved healing and development [1].
Molecular Formula: C121H200N42O39
Chemical Compound Sequence: H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Molecular Weight: 2888.16 g/mol
View the HPLC Certificate here.
Buy PEG-MGF – Available in 2 mg peptide vials.
Please note you will also require additional products for peptide reconstitution – please find the full range of peptide consumables here.
PEG-MGF (Pegylated Mechano Growth Factor) is a derivative of Insulin-like Growth Factor-1 (IGF-1) and plays a critical role in muscle repair and growth [2]. It operates by targeting damaged muscle fibres and activating satellite cells, which are essential for muscle regeneration. This activation allows satellite cells to proliferate and merge with existing muscle fibres, promoting hypertrophy and restoring tissue integrity [3].
The addition of a polyethylene glycol (PEG) molecule to MGF extends its half-life significantly, making it a more stable peptide, allowing for prolonged therapeutic action in the body [4]. This pegylation enhances its effectiveness, enabling it to maintain longer-lasting interactions with muscle tissue.
Further studies have found that after physical stress or injury, PEG-MGF not only boosts recovery by accelerating repair processes but also contributes to building new muscle fibres and reducing muscle inflammation. By encouraging protein synthesis and tissue regeneration, it supports stronger, healthier muscles [2].
Buy PEG-MGF Nasal Spray from PharmaLabGlobal offering a non-invasive and effective way of researching PEG-MGF. Peptide Nasal Sprays are convenient when research requires timed dosage for peptides.
PEG-MGF peptide is currently under clinical investigation, however preliminary findings suggest it could have the following applications:
Muscle Repair
PEG-MGF (Pegylated Mechano Growth Factor) promotes muscle repair by activating satellite cells, which are crucial for muscle regeneration avoiding muscle weakness. These cells help repair damaged fibres by proliferating and integrating with the existing tissue, accelerating the healing process [1]. The peptide also enhances protein synthesis, fostering the growth of new muscle fibres and strengthening the tissue. Its pegylation extends its half-life, allowing it to remain active longer in the body for sustained repair and recovery. This prolonged activity makes PEG MGF peptide highly effective for muscle development and regeneration following physical stress or injury [4]. Proper dosing and medical supervision are essential to minimize the risks of overuse or hormonal imbalance.
Enhanced Muscle Growth
PEG-MGF stimulates muscle growth by activating satellite cells, which are essential for muscle regeneration and repair. These cells merge with existing muscle fibres, promoting hypertrophy and enhancing overall muscle mass [5]. The peptide also boosts protein synthesis, a key process for constructing new muscle fibres and fostering development.
Its pegylation significantly extends its half-life, ensuring prolonged activity in the body for longer periods of time, maximizing its effectiveness in building muscle, promoting endurance and lean body mass [4]. By supporting the growth of stronger, healthier muscle tissue, PEG-MGF is particularly beneficial for recovery and development post-exercise or injury.
Cardioprotective Effects
PEG-MGF (Pegylated Mechano Growth Factor) offers cardioprotective benefits by promoting cardiac muscle repair and reducing tissue damage after myocardial injury. It activates satellite cells, essential for regenerating damaged heart tissue, and enhances protein synthesis to support repair and strengthen cardiac muscle cells [6]. The pegylation of MGF extends its half-life, ensuring prolonged therapeutic effects and sustained activity in the heart. This peptide may improve heart function and accelerate recovery time after cardiac stress or injury, making it valuable for cardiac health management [7].
Improves Bone Health
PEG-MGF (Pegylated Mechano Growth Factor) supports bone health by stimulating osteoblast activity, the cells responsible for bone formation. This peptide promotes bone repair and regeneration, including increasing bone density, making it particularly beneficial for individuals recovering from injuries or managing bone-related conditions. The extended half-life, allows sustained action in the body for enhanced therapeutic benefits. By supporting the repair of microfractures and strengthening the bone structure, PEG-MGF helps improve overall skeletal health and reduces the risk of fractures [8].
Improved Cognitive Function
PEG-MGF (Pegylated Mechano Growth Factor) may enhance cognitive function by supporting neural repair and promoting brain plasticity. By activating pathways involved in neurogenesis, it encourages the growth of new neurons and the regeneration of damaged ones [9]. Its pegylation extends its half-life, allowing for prolonged effectiveness in the brain. This peptide could also protect neurons against damage caused by oxidative stress or injury, aiding recovery in neurological conditions. Additionally, it may improve memory and learning by fostering healthier neural connections.
Buy PEG-MGF Pre-Mixed Pen Kit. Peptide pen and ready reconstituted peptide refill cartridges supplied by PharmaLabGlobal for research purposes.
Please note the product use of research peptides from PharmaLabGlobal are for research use only.
What is the difference between MGF and PEG-MGF?
The primary difference between MGF (Mechano Growth Factor) and PEG-MGF (Pegylated Mechano Growth Factor) lies in their structure and duration of activity:
Structure: MGF is a natural variant of IGF-1 (Insulin-like Growth Factor-1) that is released in response to muscle stress or damage. It plays a key role in muscle repair and regeneration by activating satellite cells. PEG-MGF is a modified version of MGF that has undergone a process called pegylation, where a polyethylene glycol (PEG) molecule is attached to the peptide. This modification enhances its stability and bioavailability.
Half-Life and Duration: MGF has a very short half-life, lasting only a few minutes in the bloodstream, which limits its effectiveness when administered externally. PEG-MGF, due to pegylation, has an extended half-life, allowing it to remain active in the body for a longer period. This makes it more effective for sustained muscle repair and growth.
In summary, PEG-MGF is essentially an improved version of MGF, designed to overcome the limitations of MGF’s short half-life, offering longer-lasting and more consistent benefits for muscle recovery and growth.
[1] Kaczmarek A, Kaczmarek M, Ciałowicz M, Clemente FM, Wolański P, Badicu G, Murawska-Ciałowicz E. The Role of Satellite Cells in Skeletal Muscle Regeneration-The Effect of Exercise and Age. Biology (Basel). 2021 Oct 18;10(10):1056.
[2] Zabłocka B, Goldspink PH, Goldspink G, Górecki DC. Mechano-Growth Factor: an important cog or a loose screw in the repair machinery? Front Endocrinol (Lausanne). 2012 Nov 1;3:131.
[3] Bazgir B, Fathi R, Rezazadeh Valojerdi M, Mozdziak P, Asgari A. Satellite Cells Contribution to Exercise Mediated Muscle Hypertrophy and Repair. Cell J. 2017 Winter;18(4):473-484.
[4] Gao Y, Joshi M, Zhao Z, Mitragotri S. PEGylated therapeutics in the clinic. Bioeng Transl Med. 2023 Sep 22;9(1):e10600.
[5] Fukada, Si., Higashimoto, T. & Kaneshige, A. Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration. Skeletal Muscle 12, 17 (2022).
[6] Doroudian G, Pinney J, Ayala P, Los T, Desai TA, Russell B. Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes. Biomed Microdevices. 2014 Oct;16(5):705-15.
[7] Peña JR, Pinney JR, Ayala P, Desai TA, Goldspink PH. Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction. Biomaterials. 2015 Apr;46:26-34.
[8] Deng M, Zhang B, Wang K, Liu F, Xiao H, Zhao J, Liu P, Li Y, Lin F, Wang Y. Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits. Int Orthop. 2011 Jul;35(7):1099-106.
[9] Tang JJ, Podratz JL, Lange M, Scrable HJ, Jang MH, Windebank AJ. Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain. Mol Brain. 2017 Jul 7;10(1):23.
[10] Dluzniewska J, Sarnowska A, Beresewicz M, Johnson I, Srai SK, Ramesh B, Goldspink G, Górecki DC, Zabłocka B. A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB J. 2005 Nov;19(13):1896-8.
PEG-MGF Pre or Post Work Out?
This article discusses the optimal timing for using PEG-MGF, a peptide known for its muscle repair and growth benefits. It highlights that PEG-MGF is most effective when used post-workout or on recovery days, as it supports muscle regeneration and repair by activating satellite cells. The blog also compares PEG-MGF to MGF, emphasizing its extended half-life and superior effectiveness. Additionally, it contrasts PEG-MGF with BPC-157, noting that while PEG-MGF is ideal for targeted muscle repair, BPC-157 is more versatile for healing connective tissues and reducing inflammation.
The Ultimate Guide to Muscle Building Peptides
This blog provides a comprehensive guide to muscle-building peptides, explaining their role in enhancing muscle mass, recovery, and overall performance. It details how these peptides stimulate growth hormone and IGF-1 production, promoting protein synthesis and muscle repair.
The article highlights popular peptides like CJC-1295, BPC-157, TB-500, and PEG-MGF, each with unique benefits such as improving joint health, accelerating recovery, and increasing muscle cell proliferation.
Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)
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