Elamipretide SS-31 Peptide Vial

Description

Elamipretide SS-31

SS-31 Elamipretide is a mitochondria-targeted peptide that has shown potential in improving various age-related functional deficits. Clinical trials have demonstrated its ability to attenuate age-associated heart dysfunction and improve mitochondrial dysfunction, synaptic impairment, and memory impairment induced by lipopolysaccharide.

Additionally, research suggests that Elamipretide may improve cognitive dysfunction and inflammatory responses in the hippocampus. While further research is needed to fully understand its mechanisms and potential therapeutic applications, these findings highlight the potential health benefits of SS-31 Elamipretide in addressing age-related conditions.

The SS-31 provides various advantages: the ability to target and accumulate on the inner membrane of mitochondria, the ability to protect it against mitochondrial depolarisation, and the ability to be a small water-soluble peptide. Elamipretide SS-31 can enter the mitochondria and impact mitochondrial function maintenance.

Specifications

Sequence: d-Arg-Dmt-Lys-Phe-NH2
Molecular Formula: C32H49N9O5
Molecular Weight: 639.8 g/mol

Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

Size: 10mg | 50mg

Research

Physical endurance

A neuron’s ability to operate and survive is directly influenced by the activity of its mitochondria [1]. Moreover, during apoptosis, mitochondria play a vital role in energy transfer from the cell’s intracellular to extracellular compartments [2]. The mitochondria are responsible for human physical activity and endurance. That is, human survival depends on mitochondrial energy production. As a result, patients with mitochondrial dysfunction may suffer from severe fatigue and require medicine to improve mitochondrial activity.

An 8-week study found elamipretide to be beneficial in elderly mice. Elamipretide SS-31 Peptide Vial improves skeletal muscle function and exercise tolerance by restoring cellular redox balance. However, a shift in redox homeostasis in elderly muscles is also linked to energy shortages and exercise intolerance [3].

Recognizing elamipretide’s benefits on physical endurance, researchers are testing it for the treatment of Barth Syndrome, a condition characterized by skeletal muscle weakness and physical impairment. Twelve weeks of daily elamipretide injections relieved Barth Syndrome and specific heart problems [4].

Aside from treating illnesses like Barth Syndrome, elamipretide can help the elderly maintain their independence and improve their quality of life by slowing down the ageing process. In addition, Elamipretide’s effects on physical endurance are anticipated to translate from animal research to human use.

Cognitive effects

The brain’s proper blood supply functioning is critical to its overall health. However, mitochondrial oxidative stress contributes to cognitive decline as we age. Therefore, researchers carried out a study to learn whether or not treating mitochondrial oxidative stress with the drug elamipretide has any positive effects on cognition by reducing oxidative damage.

Treatment with elamipretide boosted cerebral blood vessel dilatation considerably in a 2-week trial on aged mice [5], which was linked to improved working memory and motor skill development. According to the findings of clinical trials, elamipretide may be used to improve oxidative damage and prevent or treat ageing-related cognitive decline.

Prevention of cardiovascular disease

Elamipretide can reduce the risk of cardiovascular disorders, particularly diastolic dysfunction, an age-related heart ailment. Diastolic dysfunction is caused by the hardening of the heart’s ventricles. Over time diastolic dysfunction can lead to heart failure.

In animal experiments conducted over 8-weeks, Elamipretide SS-31 significantly reversed diastolic dysfunction in aged mice by regulating proton leak and lowering mitochondrial reactive oxygen species in heart muscle cells [6]. The study concluded that addressing mitochondrial dysfunction could reverse age-related heart problems including heart failure.

Elamipretide has good potential; however, it is still being studied and only licensed for research use. If the effects of this peptide are consistent in human trials, it may be an additional therapy option for numerous health issues.

Mitochondrial dysfunction

Cellular energy production is impaired due to mitochondrial dysfunction, which causes mitochondrial degeneration and many other disorders. Elamipretide can treat mitochondrial dysfunction because of its regeneration properties on the inner mitochondrial membrane, resulting in numerous positive consequences [7].

Elamipretide SS-31 stabilizes the inner mitochondrial membrane, preventing mitochondrial decline and increasing mitochondrial performance. Elamipretide can boost cellular energy production since the mitochondria are essential to the human body and are responsible for manufacturing cellular energy.

Elamipretide has improved physical endurance in patients with diseases connected to exercise intolerance by enhancing energy production, as scientists have recognized this chain of favourable events.

Summary

SS-31 Elamipretide, a mitochondria-targeted peptide, offers several potential health benefits. Research suggests that it can improve skeletal muscle function and increase exercise capacity by restoring redox homeostasis in cells. Elamipretide has also shown promise in addressing age-related cognitive impairment by promoting mitochondrial and synaptic health while reducing oxidative stress and neuroinflammatory responses.

Additionally, this peptide has been found to enhance functional connectivity in the hippocampus and protect mitochondria in conditions such as metabolic syndrome. These findings highlight the potential of SS-31 Elamipretide in addressing various age-related issues and improving overall mitochondrial function. However, further research is needed to fully understand its efficacy and safety.

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 29391029/

[2] https://pubmed.ncbi.nlm.nih.gov/ 21321998/

[3] https://pubmed.ncbi.nlm.nih.gov/ 26820564/

[4] https://www.nature.com/articles/ s41436-020-01006-8

[5] https://onlinelibrary.wiley.com/ doi/full/10.1111/acel.12731

[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7377906/

[7] https://jneuroinflammation.bio medcentral.com/articles/10.1186/ s12974-019-1627-9

Buy Elamipretide SS-31 Peptide vial

Pharma Lab Global is one of the best locations to purchase high purity Elamipretide SS-31 peptide for research use. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy SS-31 Elamipretide Nasal Spray and Elamipretide SS-31 50mg Pre Mixed peptide. Buy SS-31 Elamipretide peptide from Pharma Lab Global today!

TO PURCHASE PRODUCTS FROM OUR WEBSITE YOU MUST BE AT LEAST 21 YEARS OF AGE.

DISCLAIMER: All products sold by PharmaLabGlobal are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.