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GLP-1 Peptide Vial

GLP-1 (Glucagon-Like Peptide 1) is an incretin hormone that plays a crucial role in regulating blood sugar levels by stimulating insulin release and inhibiting glucagon secretion, making it a key player in the management of diabetes. Additionally, GLP-1 has been associated with potential benefits for weight management and cardiovascular health, positioning it as an intriguing target for therapeutic interventions beyond glycemic control.

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Description

GLP-1 Peptide Vial

GLP-1 peptide is known to be insulin-stimulating. Glucagon Like Peptide-1 (GLP-1), also known as Liraglutide, has an effect on insulin release. This effect helps to trigger the glucose-stimulated insulin secretory response.

GLP-1 agonists promote glycemic insulin secretion, slow stomach motility, increase early satiety and decrease glucagon level following meals and thus have hypoglycemic effects even after intravenous administration, without hypoglycemia. Glucagon-like peptide 1 can be used to regulate the appetite after a meal. It also leads to an increase in insulin production. The natural hormone GLP-1 is found in the cells of the small intestine.

In pharmacological doses, GLP-1 agonising infusion improved satiation and caused significant weight loss. Glucagon Like Peptide-1 therapy decreases human eating, appetite and hunger and encourages fullness and satiety as a result of weight loss.


Specifications

Sequence: HAEGTFTSDVSSYLEG QAAKEFIAWLVRGRG

Molecular Formula: C172H265N43051

Molecular Weight: 3751.24 g/mol

Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

Size: 2mg | 10mg


GLP-1 Research

Diabetes

Glucagon Like Peptide-1 diabetes effects are strong. The incretin effect occurs when blood sugar levels are lowered by metabolic hormones. The key hormones involved are GIP and GLP-1, with GLP-1 being more potent in cases of high blood glucose levels [1].

GLP-1 receptors have been discovered on pancreatic beta cells, showing that the peptide directly increases pancreatic insulin transport. Further research suggests that GLP 1 plus sulfonylureas can cause moderate hypoglycemia.

Animal studies have indicated that increased insulin secretion increases protein synthesis and muscle amino acid absorption and decreases protein breakdown.

GLP-1 peptide hormone stimulates the development and proliferation of pancreatic beta cells in animal models. Further research shows Liraglutide peptide suppresses beta cell death, indicating it may be beneficial in treating diabetes and protecting the pancreas from harmful side effects.

In a 2006 GLP-1 experiment, the peptide stopped inflammatory cytokine-induced beta-cell death. In addition, GLP1 medicines protected islet cells in type 1 diabetes mice models, suggesting it may prevent disease initiation [2].

Weight Loss

In one study, GLP-1 supplements were given to mice to help them lose weight. Unfortunately, due to the lack of clinical studies, it is not FDA authorized and should only be used in medical research. However, the FDA approves some GLP-1 agonists for obesity management as a prescription medication given by healthcare professionals as part of a treatment plan for diabetes management.

GLP1 injection into the brains of mice reduced food intake [3]. The medication works to increase sensations of fullness, avoiding overeating. GLP-1 gastrointestinal side effects include a delayed gastric emptying. Long-term weight loss is related to significant improvement in heart disease risk and haemoglobin A1C levels. The latter is a proxy marker for diabetes severity and treatment-induced blood sugar control [4].

Cardiovascular

Recent research shows that GLP-1 receptors improve heart function by increasing heart rate and decreasing LV end-diastolic pressure. As established in animal studies, lowering LV end-diastolic stress considerably impacts cardiovascular health [5].

Research indicates that glucagon peptide may help reduce the effects of cardiac arrest. In addition, because Glucagon Like Peptide-1 enhances heart muscle glucose uptake, it helps weaker muscle cells work better and prevents cell death [6].

In dogs, high Glucagon Like Peptide-1 doses improved LV performance and decreased systemic vascular resistance, lowering blood pressure, reducing high cholesterol and heart strain. These benefits can help prevent long-term complications such as high blood pressure, heart failure, vascular thickening, reduce the risk of a heart attack and LV remodelling. In addition, experts say Glucagon Like Peptide-1 doses after heart damage benefit animal models [7].

Brain

The GLP-1 hormone peptide has been shown to improve cognition and protect against neurodegenerative illnesses like Alzheimer’s. In addition, research studies have shown that GLP-1 improved associative and spatial learning in mice with gene abnormalities [8].

Glucagon Like Peptide-1 therapy can buffer excitotoxic neuron damage in mice and even increase neurite outgrowth in cultured cells. However, more research is needed to learn how GLP-1 impacts neurogenerative diseases and if it can stop or reverse them [9].

GLP-1 and exendin-4 also appear to lower amyloid-beta levels in the brain, a component of Alzheimer’s plaques. Delaying amyloid beta accumulation may not completely protect against AD, but the study thus far is quite encouraging. Naturally, thorough clinical trials are required to confirm its safety and efficacy [10].

Summary

Glucagon Like Peptide-1 is a medication that has the potential to treat a wide range of conditions, including diabetes, obesity, and cardiovascular disease. It is the active ingredient in many new FDA approved weight loss drugs developed to aid people in their weight management.

According to studies, it may help treat and prevent diabetes, aid in Alzheimer’s disease by managing blood glucose levels, accelerate fat reduction, and improve cardiovascular health.

Glucagon Like Peptide-1 Ras, unlike many other type-2 diabetes drugs, is particularly successful at lowering blood sugar levels after eating without causing hypoglycemia. Although further research is needed, this hormone group offers great hope for those suffering from diabetes. In addition, animal studies have demonstrated that the therapy reduces the risk of serious heart disorders such as cardiovascular disease and heart attacks.

References:

[1] https://pubmed.ncbi.nlm.nih.gov/ 17928588/

[2] https://pubmed.ncbi.nlm.nih.gov/ 16643856/

[3] https://www.nature.com/articles/ nm0700_802

[4] https://pubmed.ncbi.nlm.nih.gov/ 16776751/

[5] https://pubmed.ncbi.nlm.nih.gov/ 12746281/

[6] https://diabetesjournals.org/ diabetes/article/54/1/146/14684/ Glucagon-like-Peptide-1-Can-Directly-Protect-the

[7] https://pubmed.ncbi.nlm.nih.gov/ 15313949/

[8] https://pubmed.ncbi.nlm.nih.gov/ 12925848/

[9] https://pubmed.ncbi.nlm.nih.gov/ 12183643/

[10] https://pubmed.ncbi.nlm.nih.gov/ 15270203/

Buy Glucagon Like Peptide-1 Vial

Pharma Lab Global is one of the best locations to purchase high purity Glucagon Like Peptide-1  for research. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy GLP-1 Nasal Spray and GLP-1 2mg Peptide Pre Mixed peptide. Buy GLP-1 Peptide from Pharma Lab Global today!


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DISCLAIMER: All products sold by Pharma Lab Global are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.

Additional information

Size

2mg Vial, 10mg Vial, Kit = 2mg vial, bac water, syringes, Kit = 10mg vial, bac water, syringes