HGH Fragment Nasal Spray

Description

HGH Fragment Nasal Spray

HGH Fragment nasal spray – the 176th and 191th amino acids from the regular polypeptide human growth hormone (HGH) sequence are torn off to create HGH Fragment 176-191. Fragment 176-191 has been shown to increase fat burning in laboratory rodents with large fat stores.

Whilst HGH fragment nasal spray retains the human growth hormone’s fat-burning effects, it does not increase insulin-like growth factor-1 (IGF-1), negatively impact on carbohydrate metabolism, alter insulin sensitivity, nor does it increase long bone growth. These specific effects of fragment 176-191 have been the subject of research into human fat metabolism and possibly develop anti-obesity drugs.

Specifications

Molecular Formula: C78H125N23O23S2

Sequence: Tyr-Leu-Arg-IIe-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Molecular Weight: 1817.12 g/mol

Size: 15ml | 30ml

Research

Regulating Blood Sugar:

In animals, the c terminal end of hGH is responsible for its hypoglycemic (blood sugar decreasing) effects. 176-191 is the most effective synthetic derivative for lowering blood sugar. As a result of a rise in plasma insulin levels [1]. Prediabetes and type 2 diabetes may be treated with HGH fragment nasal spray.

Fat Loss And Fat Burning:

A peptide known as a “lipolytic fragment” has been proven to burn fat and reduce weight in mice. The synthesis of B3-AR (or ADRB3) is likely to be implicated because the agonist has been shown to promote skeletal muscle thermogenesis and adipose tissue fat burning. Mice lacking ADRB3, on the other hand, do not benefit from hGH or fragment 176-191.

A three-week study found that enhanced fat burning associated with fragment 176-191 correlated with increased energy expenditure and weight loss [2]. Even after being exposed to fragment 176-191 [3] only fat animals lost weight, while thin mice gained weight. Instead of ADRB3, researchers can use secondary regulatory pathways for lipolysis to examine energy homeostasis.

Promotes Cartilage Renewal:

Though HGH fragment nasal spray is being examined largely for its lipolytic capabilities, other possible advantages are being explored.

For example, a Korean study discovered that fragment 176-191 could improve the effects of hyaluronic acid injections on cartilage regeneration. Weekly injections of fragment 176-191 boosted laboratory measurements of cartilage development in rabbits, and co-administration of the peptide with hyaluronic acid (HA) enhanced the results even more.

Similarly, fragment 176-191 lowers osteoarthritis impairment when taken alone or in combination with HA. This could lead to enhanced osteoarthritis treatments and, in some situations, reduce the need for surgery [4].

Summary

HGH Fragment 176-191 is being extensively explored in the field of weight loss and lipolysis in order to better understand energy homeostasis and fat metabolism. The most active secondary area of research is connective tissue regeneration, namely cartilage repair.

HGH fragment nasal spray has largely been investigated on animals. While it preserves the fat-burning capabilities of HGH, it does not raise IGF-1 levels, have a detrimental influence on carbohydrate metabolism, change insulin sensitivity, or promote long bone formation.

A research published in the Journal of Endocrinology and Metabolism in 2013 examined six trials with HGH Fragment 176-191 to determine the frequency and extent of potential side effects. In comparison to a placebo, HGH fragment nasal spray had no effect on glucose, glucose tolerance, insulin sensitivity, or IGF-1 levels. This demonstrates that HGH fragment 176-191 provides many of the benefits of hGH while avoiding the negative side effects [5].

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 645904/

[2] https://pubmed.ncbi.nlm.nih.gov/ 11713213/

[3] https://pubmed.ncbi.nlm.nih.gov/ 11146367/

[4] https://pubmed.ncbi.nlm.nih.gov/ 26275694/

[5] https://journals.physiology.org/ doi/abs/10.1152/ajpendo.1978. 234.5.E521?journalCode=ajpendo

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