HGH Fragment Nasal Spray

Description

HGH Fragment Nasal Spray

HGH fragment nasal spray – fragment 176-191 (a modified version of AOD9604) is a lipolytic fragment of human growth hormone (hGH). Fragment 176-191 was given this name because it has been shown to increase fat burning in laboratory mice with large fat stores.

While HGH fragment nasal spray retains hGH’s fat-burning effects, it does not increase insulin-like growth factor-1 (IGF-1), negatively impact carbohydrate metabolism, alter insulin sensitivity, or increase long bone growth. The specific effects of fragment 176-191 allow it to be used to study human fat metabolism and possibly develop anti-obesity drugs.

Specifications

Molecular Formula: C78H125N23O23S2

Sequence: Tyr-Leu-Arg-IIe-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Molecular Weight: 1817.12 g/mol

Size: 15ml | 30ml

Research

Regulating Blood Sugar:

The c terminal end of hGH is responsible for its hypoglycemic (blood sugar lowering) actions in animals. For decreasing blood sugar, 176-191 is the most effective synthetic derivative. Secondary to an increase in plasma insulin levels[1].  HGH fragment nasal spray may be used to treat prediabetes and type 2 diabetes.

Fat Loss And Fat Burning:

“Lipolytic fragment” peptide has been found to burn fat and reduce weight in mice. B3-AR (or ADRB3) production is thought to be involved as the agonist has been found to increase skeletal muscle thermogenesis and adipose tissue fat burning. Conversely, mice lacking ADRB3 do not benefit from hGH or fragment 176-191.

A three-week research study indicated higher fat burning related to fragment 176-191 correlates with increased energy expenditure and weight loss [2]. Even when exposed to fragment 176-191 [3], only fat mice lost weight, while skinny mice did not. To study energy homeostasis, researchers can use secondary regulatory pathways for lipolysis instead of ADRB3.

Promotes Cartilage Renewal:

Though HGH fragment nasal spray is primarily studied for its lipolytic properties, other potential benefits are being investigated.

For example, the Korean study found that fragment 176-191 could enhance the impacts of hyaluronic acid injections in boosting cartilage regeneration. Weekly injections of fragment 176-191 increased laboratory measures of cartilage growth in rabbits, and co-administration of the peptide with hyaluronic acid (HA) increased effects even further.

Similarly, fragment 176-191, alone or in conjunction with HA, reduces osteoarthritis disability. This may lead to advanced osteoarthritis therapies and even minimize the need for surgery in some cases [4].

Summary

HGH Fragment 176-191 is being studied extensively in the field of weight reduction and lipolysis to better understand energy homeostasis and fat metabolism. Connective tissue regeneration, in particular cartilage repair, is the most active secondary area of study.

HGH fragment nasal spray has been studied primarily on animals. While it retains HGH’s fat-burning properties, it does not increase IGF-1 levels, negatively impact carbohydrate metabolism, alter insulin sensitivity, or increase long bone development.

A 2013 Journal of Endocrinology and Metabolism study analyzed six trials of HGH Fragment 176-191 to assess the rate and magnitude of probable side effects. HGH fragment nasal spray did not affect glucose, glucose tolerance, insulin sensitivity, or IGF-1 levels compared to a placebo. This shows that HGH fragment 176-191 provides many of the benefits of hGH without the unfavourable side effects [5].

References

1. https://pubmed.ncbi.nlm.nih.gov/645904/
2. https://pubmed.ncbi.nlm.nih.gov/11713213/
3. https://pubmed.ncbi.nlm.nih.gov/11146367/
4. https://pubmed.ncbi.nlm.nih.gov/26275694/
5. https://journals.physiology.org/doi/abs/10.1152/ajpendo.1978.234.5.E521?journalCode=ajpendo

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