IGF-1 LR3 Peptide Vial

Description

IGF-1 LR3 Peptide Vial

Insulin-like Growth Factor-1 Long Arginine 3, also known as IGF-1 LR3, is a modified, synthetic version of insulin-like Growth Factor-1. IGF1 LR3 remains active up to 120 times longer than conventional IGF-1 because it does not bind effectively to IGF-1-binding proteins. This increases the peptide’s half-life and enhances it’s activity. By restricting myostatin from working, IGF-1 LR3 causes cells to divide and grow, it also speeds up fat metabolism, and causes muscle repair and growth (hypertrophy).

Specifications

Molecular Formula: C400H625N111O115S9
Sequence: MFPAMPLSSLFVNGPRTLCGAE LVDALQFVCGDRGFYFNKPT GYGSSSRRAPQTGIVDECCF RSCDLRRLEMYCAPLKPAKSA
Molecular Weight: 9117.5 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble
Storage: -19˚C

Size: 0.1mg | 1mg

IGF-1 LR3 Research

Cell Division Like IGF-1

IGF1-LR3 is a powerful stimulant of cell proliferation and division, specifically it increases cell division in the kidney, liver, skin, nerve, blood, and lung tissues. IGF-1 is best understood as a hormone for maturation because it helps cells grow and change, IGF-1 helps cells mature to perform their specific duties.

The IGF1-LR3 variant stays in the bloodstream for extended periods unlike IGF-1, and IGF1-LR3 stimulates cells roughly three times more than IGF-1. This attribute renders IGF1-LR3 a far more powerful molecule which can yield greater benefits. IGF1-LR3 and all other IGF-1 derivatives don’t cause cells to grow bigger,  they cause cells to divide and multiply (hyperplasia). For example in the case of muscle, IGF1-LR3 does not increase the size of muscle cells but increases the overall number of muscle cells.

Diabetes and Fat Metabolism

Clinical studies have demonstrated that the IGF1-LR3 indirectly accelerates the breakdown of fat by attaching to both the insulin receptor and the IGF-1R receptor. These actions stimulate muscular, neuronal, and hepatic cells to absorb glucose from the bloodstream. This in turn can cause a dip in blood sugar, resulting in the liver and fat cells to break down glycogen and triglycerides. Leading to an overall decrease in adipose tissue and an increase in energy consumption (i.e. net catabolism).

IGF1-LR3 has been found to reduce insulin levels and the need for extra insulin in diabetics, which is not surprising given that it lowers blood sugar levels. This can result in a 10% reduction in the amount of insulin used to maintain the same blood sugar levels. This discovery could aid scientists in understanding how to minimise insulin doses in individuals with low insulin sensitivity and shed light on preventing type 2 diabetes, which could prove to be a significant medical break through.

Reduces Myostatin

Myostatin (also known as GDF-8) is a muscle protein that predominantly inhibits muscle cell development and differentiation. Even though this function is imperative for preventing uncontrolled hypertrophy and ensuring that injuries heal properly, there are several situations when blocking myostatin could be helpful. For example for those individuals living with Duchenne muscular dystrophy (DMD) or in people who experience muscle loss due to extended periods of immobilisation, the ability to inhibit myostatin’s action could be advantageous. Inhibiting this natural enzyme could delay or reduce muscle wasting, preserve strength, and prevent disease.

In animal studies using mouse models with Duchenne muscular dystrophy,  IGF1-LR3 and other IGF-1 analogues demonstrated that they can prevent muscle cells from dying and stop apoptosis by counteracting the effects of myostatin. Due to its extended half-life, IGF1-LR3 is particularly effective at countering myostatin and appears to function by stimulating a muscle protein known as MyoD [1], [2]. MyoD is the protein typically triggered by activity (e.g., weightlifting) or tissue injury which is responsible for muscle growth.

Research in Longevity

IGF1-LR3 promotes tissue preservation and repair throughout the body, making it a protective peptide against cell damage and ageing. Research on cows and swine suggests that IGF1-LR3 treatment may be an effective method for counteracting the ageing effects of cells. Ongoing studies on mice aim to establish if IGF1-LR3 might be effective in delaying the advancement of various diseases, including dementia, muscular atrophy, and renal disease. This study demonstrates that administering IGF-1 can extend life span and decrease disability. [3], [4], [5]

Glucocorticoid Signalling

Glucocorticoids, largely released by the adrenal glands, are essential medications used to regulate pain and decrease inflammation in conditions such as autoimmune illnesses, neurological injuries, cancer amongst others. Unfortunately, glucocorticoids have a number of unpleasant side effects, including muscle atrophy, weight gain, and loss of bone density. There is some interest in using IGF1-LR3 to decrease the negative effects of glucocorticoids and could potentially lead to a more effective therapy. [6]

Summary

The IGF-1 LR3 peptide has various advantages for the formation and growth of muscle. It helps those who want to gain lean muscle since it has been demonstrated to boost muscle mass and strength. IGF-1 LR3 can also prevent muscular atrophy, help with fat loss, lower inflammation, increase endurance, and improve sports performance. By using stored fat as an energy source, it also encourages an increase in energy and metabolism. Enhanced energy levels, increased insulin sensitivity, increased metabolic rate, and improved cognitive function are further advantages. IGF-1 LR3 peptide may be advantageous for people who want to get in better shape and perform better physically overall.

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 24575400/

[2] https://pubmed.ncbi.nlm.nih.gov/ 26580671/

[3] https://pubmed.ncbi.nlm.nih.gov/ 8491152/

[4] https://pubmed.ncbi.nlm.nih.gov/ 22522510/

[5] https://pubmed.ncbi.nlm.nih.gov/ 22714057/

[6] https://pubmed.ncbi.nlm.nih.gov/ 22688888/

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