IGF-1 DES Nasal Spray

Description

IGF1 DES Nasal Spray

Insulin-like growth factor-1, IGF1-DES, is a natural shortened form (splice variant). IGF-1 DES is found in the breast milk, brain, and uterine tissue. Because of its increased bioavailability, this protein appears to be more effective than conventional IGF-1. These include IBD, autism, and other neurological disorders. Like all IGF-1, it promotes muscle and connective tissue healing.

IGF1-DES Research findings

IGF1-DES binds to the IGF-1 receptor with great affinity, according to scientific and clinical studies. That’s because it’s 10-fold more effective than conventional IGF-1 at inducing cell hypertrophy and proliferation thanks to its reduced affinity to IGF-binding proteins [1].

Not widely studied in clinical settings, DES(1-3) IGF-1 could be used to generate anabolism in catabolic situations (such as muscular dystrophy) or to treat IBD. IGF-1, specifically DES(1-3) IGF-1, has a significant potential to create and retain muscle. Additionally, IGF-1 stimulates the proliferation and differentiation of skeletal muscle stem cells (satellite cells) — the only hormone that can stimulate this process of new muscle cell growth. Many neurological illnesses could benefit from DES(1-3) IGF-1 treatment [2].

Neurological

IGF-1 promotes neuron development, differentiation, and survival. The protein is crucial for synapse development, memory, learning and other functions. IGF-1 is essential for maturing synapses and is required for appropriate levels of pres-synaptic synapsin-1, a neurotransmitter-regulating protein.

In addition, the peptide helps preserve synaptic structure in the post-synaptic PSD-95 protein. Without IGF-1, synaptic growth is impaired, causing motor, behavioural, cognitive, and language problems.

IGF-1 has been found beneficial in treating both Rett syndrome and chromosome 22 deletion syndrome by preserving neuron density and excitatory synapses. IGF-1 reduces the harmful consequences of NMDA over-stimulation, leading to cell death. IGF-1 and its analogues are being tested as an experimental therapy for humans with these debilitating diseases [3].

IGF-1 clinical trials in MS, ALS, PD, and AD had inconsistent outcomes. In ALS, IGF-1 treatment reduced disease progression, improved muscle strength, respiratory function, and quality of life. However, the peptide barely affected MS. In rat models of PD, IGF-1 preserves dopaminergic neurons and enhances behaviour [4].

More research is needed to understand these disorders’ origins and how IGF-1 DES treats them. The destruction causes MS to the cells around neurons; thus, it’s not unexpected that the peptide has no effect. Nevertheless, IGF-1 DES and other IGF-1 mimics can help scientists understand the pathophysiology of these disorders and identify viable remedies.

Autism

IGF-1 may be relevant in neurological disorders, including autism, according to research. For example, low IGF-1 concentrations in the brain, especially at a young age, may disturb normal development and be significant in the pathophysiology of autism [5].

IGF-II and IGF-1 DES repair autism impairments in mice models. Five days of IGF-II improved social interaction, novel-object recognition, contextual fear conditioning, repetitive/compulsive behaviour, and grooming, and it also improved memory in mice [6].

Autism is likely caused by disturbances in synapse development, similar to fragile X disease, tuberous sclerosis, and Angelman syndrome. IGF-1 and its equivalents, which affect synapses, are appropriate for treating these illnesses [7].

Cognitive Aging

Adults and children need IGF-1. The brain modifies the peptide to make it shorter in adulthood, suggesting that IGF-1 analogues may have higher therapeutic potential than natural IGF-1. IGF-1 DES molecules quickly pass the blood-brain barrier, making them more effective exogenously. IGF-1 and its equivalents prevent neuronal death and safeguard neurons from stroke, Alzheimer’s, Parkinson’s, etc [8].

IGF-1 and its equivalents are beneficial in neurological illnesses. Research suggests that IGF-1 DES may improve synaptic transmission and cognition in normal rats. This could help learning and memory as organisms age and brain IGF-1 levels fall. IGF-1 DES increases excitatory post-synaptic potential by 40% [9]. This shows the peptide could affect cognitive performance, especially age-related synapse dysfunction.

Immune Function

Many immune system cells have IGF-1 receptors, including mononuclear cells and neutrophils. Research reveals that IGF-1 DES can increase immune function by enhancing hydrogen peroxide release in mononuclear cells and stimulating neutrophils to develop into pathogen-killing blastocytes [10]. In all cases, IGF-1 DES is more active in triggering these changes than IGF-1, suggesting the peptide may be a beneficial adjuvant to antibiotics and other infectious disease treatments. Research on IGF 1 DES and immunological function is experimental but promising.

Improves Wound Healing

Skin fibroblasts restore injured tissue. In some cases, these cells generate IGFBPS, which reduces IGF-1’s effect on other receptors. However, inflammatory cytokines may change IGFBP levels, hindering recovery. By giving IGFBP-unaffected peptides, inflammatory cytokines can be avoided, boosting fibroblast proliferation and differentiation [11]. This speeds up wound healing.

Cancer

Cancer cells are undifferentiated or in the early stages of differentiation, rendering the cells dysfunctional and challenging to cure. Cells in subsequent phases of differentiation grow slower. Forcing tumour cells to differentiate could halt growth. Cell culture research shows that IGF-1 DES can push cancer cells to differentiate, slowing tumour growth by blocking differentiation [12].

IGF1-DES Peptide summary

IGF-1 DES maintains many of IGF-1’s activities, including muscle growth and neuron protection. It doesn’t bind IGFBPs, though. This makes IGF-1 DES more effective in many ways, such as helping it enter the brain more quickly when delivered exogenously. As a result, IGF-1 DES shows potential in neurodevelopment, stroke, cancer, wound healing, autism, etc.

References

1. https://pubmed.ncbi.nlm.nih.gov/10605625/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675852/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064155/
4. https://pubmed.ncbi.nlm.nih.gov/26780584/
5. https://pubmed.ncbi.nlm.nih.gov/28954393/
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783959/
7. https://pubmed.ncbi.nlm.nih.gov/25695134/
8. https://pubmed.ncbi.nlm.nih.gov/17582656/
9. https://pubmed.ncbi.nlm.nih.gov/15985695/
10. https://pubmed.ncbi.nlm.nih.gov/7508487/
11. https://pubmed.ncbi.nlm.nih.gov/7684061/
12. https://pubmed.ncbi.nlm.nih.gov/1281142/

Buy IGF1-DES Peptide vial 1mg

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IGF1-DES Specifications

Molecular Formula: C₃₁₉H₄₉₅N₉₁O₉₆S₇
Molecular Weight: 7365.4225 g/mol
Sequence: TLCGAELVDALOFVCGDROFVFNKPTGYGSSSRRAPOTGIVDECCFRSCOLRRLEMYCAPLKAAKSA
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

IGF1-DES Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

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All products listed on this website and provided through Pharma Labs Global are intended for medical research purposes only. Pharma Lab Global does not encourage or promote the use of any of these products in a personal capacity (i.e. human consumption), nor are the products intended to be used as a drug, stimulant or for use in any food products.