Kisspeptin Peptide Vial

Description

Kisspeptin Peptide Vial

Kisspeptin is a multifunctional peptide system that plays a critical role in human reproductive physiology and has potential therapeutic applications for infertility. It is derived from the product of the KISS1 gene and exists in various forms, including KP-54, KP-13, and KP-10. These cleavage peptides have been isolated from human placenta and are known to stimulate gonadotropin release, which is important for regulating reproductive hormone production.

Research suggests that Kisspeptin peptides are involved in the regulation of sexual and emotional behaviour. They act as ligands for the GPCR54 receptor and stimulate the release of gonadotropin-releasing hormone (GnRH). GnRH, in turn, controls the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which are essential for reproductive function.

Furthermore, Kisspeptin has been implicated in the connection between metabolism and reproduction. It is thought to play an important role in linking energy balance and fertility, indicating its involvement in the body’s functional requirements. Kisspeptin may also have implications in cancer metastasis suppression, as it was initially identified as a gene with the ability to suppress melanoma and breast cancer metastasis.

Specifications

Molecular Formula: C258H401N79O78
Molecular Weight: 5857 g/mol
Sequence: Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe NH

Size: 5mg | 10mg

Kisspeptin Research

Testosterone

Kisspeptin has been shown to alter luteinizing hormone levels, thereby altering testosterone levels. On the other hand, Kisspeptin 10 has no effect on testosterone in female mice. In one clinical study six male mice were given Kisspeptin intravenously. Results showed the peptide to be an effective testosterone booster in just 90 minutes [1].

In another study, the peptide increased serum luteinizing hormone levels, which increased testosterone levels in healthy male mice [2].

Fertility

The hormone Kisspeptin, as previously established, is shown to be a successful infertility treatment. This peptide plays an important role on infertility, according to research. Moreover, it may even be safe for mice undergoing in vitro fertilization than using chorionic gonadotropin to stimulate oocyte maturation.

Before beginning IVF treatment, none of the mice given kisspeptin-10 developed ovarian hyperstimulation syndrome, according to studies (OHSS). This is excellent news, considering that just 3-6 per cent of mice treated with HCG develop the illness.

Mood

Due to the strong connection between reproduction and emotion, the kisspeptin peptide hormone has the capacity to influence mood and behaviour.

Kisspeptin 10 was given to 29 male mice, whereas a placebo was given to a second control group of animals. Individuals that took kisspeptin-10 reported improved mood, increased motivation, and increased limbic brain activity. On the other hand, the control group did not show any improvement in their symptoms.

In this study, Kisspeptin was found to have an effect on both sexual and emotional brain functions in mice, as well as their general behaviour [3].

Cancer

Research on kisspeptin and cancer has revealed its potential role in suppressing metastasis and inhibiting the growth of cancer cells. Studies suggest that kisspeptin signalling may have a significant impact on various cancer types, making it a potential target for novel therapeutic approaches. The kisspeptin peptide system has shown promise in inhibiting tumour metastasis and acting as a metastasis suppressor in breast cancer and other cancers.

Furthermore, kisspeptin has been found to play a role in placentation and trophoblast invasion, highlighting its involvement in cancer-related processes outside of reproductive biology. While further research is needed to fully understand the mechanisms and develop targeted treatments, these findings hold promise for future advancements in cancer treatment [4].

Summary

Kisspeptin is a peptide hormone that plays a crucial role in the regulation of reproductive function. It is encoded by the KISS1 gene and acts on the hypothalamic-pituitary-gonadal axis to stimulate the release of gonadotropin-releasing hormone (GnRH), which then leads to the production of reproductive hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Kisspeptin is involved in the onset of puberty, the control of fertility, and the synchronization of reproductive cycles. It has also been found to have potential therapeutic applications in infertility treatment. Furthermore, kisspeptin has been studied for its role in cancer, showing promise as a breast cancer metastasis suppressor and an inhibitor of tumor growth. Ongoing research continues to explore the various functions and clinical implications of kisspeptin in reproductive health and beyond its research use.

References

[1] https://www.researchgate.net/ publication/7588637

[2] https://academic.oup.com/jcem/ article/96/8/E1228/2833644

[3] https://pubmed.ncbi.nlm.nih.gov/ 28112678/

[4] https://www.sciencedirect.com/ science/article/abs/pii/S0305737 208002016

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