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LL-37 (Cap-18)

LL-37 (Cap-18)

LL-37 is widely recognised for its antimicrobial properties.

5 mg Vial

£35.99£42.48

SKU PLG: LL-37 vial Categories ,

Description

LL-37 Cap-18 Peptide Vial 5mg

Recent studies by our group have shown that peptide LL-37 Cap-18 is an antiseptic agent that can be used to treat fungal infections and bacterial infections. It has proved to be useful against bacterial skin infections, particularly in cases where the disease is resistant to most anti-fungal agents. In addition, it has also shown promise in fighting against bacterial skin infections due to fungal causes, such as candida albicans. Recently, researchers have been studying the peptide LL-37’s benefits for cathelicidic dermatitis and how this substance can benefit people with this chronic skin disorder.

LL-37 can be used to treat cathelicidic dermatitis as this substance has proved effective in reducing the inflammation caused by this condition. This Peptide works by inhibiting the production of proinflammatory cytokines, which is one of the main causes of inflammation that can be attributed to cathelicidic dermatitis. As a result, it helps to eliminate the yeast and bacteria that cause cathelicidic skin disorder, thus relieving the symptoms associated with the condition.


Specifications

Molecular Formula: C205H340N60O53
Sequence: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
Molecular Weight: 4493 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

LL-37 Storage: -20˚C

Size: 5mg


Research

Antimicrobial

As an immune system component, LL-37 operates by adhering to and interfering with bacterial lipopolysaccharide (LPS), a critical component of gram-negative bacteria. Additionally, it inhibits the growth of gram-positive bacteria, making it effective against staph infections and other bacterial-related disorders [1].

According to studies on skin infections, normal skin has minimal levels of LL-37, but it rapidly accumulates when pathogens penetrate the body. Additionally, as seen in animal experiments, this peptide functions well with other proteins such as mice beta-defensin 2 to defeat the infection [2].

Tissue repair

LL-37 cap-18 peptide is antibacterial and controls the balance of pro- and anti-inflammatory chemicals in mice. However, scientists say it’s tough to balance inflammation and tissue recovery. Because while inflammatory reactions assist the body fight invaders, they can also hinder healing, induce scar tissue formation, and perhaps trigger autoimmune illnesses. Fortunately, LL-37 therapy balances inflammation and healing by affecting macrophages, which cause inflammation when infections penetrate the body [3].

When macrophages recognize pathogens, they alert the rest of the body to defend. Next, the immune system destroys the infections, while macrophages produce new signals to lower inflammation. According to animal studies, LL-37 cathelicidin peptide reverses macrophage activation, turning anti-inflammatory macrophages pro-inflammatory.

LL-37 also inhibits biofilm formation, which can help heal wounds caused by P. aeruginosa and Staph infections. In addition, as shown in animal studies, it can kill bacteria and promote wound healing by interacting with fibroblasts and keratinocytes [2].

Inflammation diseases

LL37 is primarily an antibacterial peptide, but it also helps inflammatory illnesses like lupus, arthritis, and psoriasis. Ll-37 modulates the immune system by decreasing apoptotic keratinocytes, enhancing IL-18 and IFN-alpha generation, modifying neutrophils, and reducing atherosclerotic plaque levels.

The immune system isn’t always affected in the same manner by LL-37/CAP-18. In some circumstances, inactivated T-cells respond to the peptide by increasing their inflammatory activity, while activated T-cells decrease it.

Further research shows that LL 37 Cap-18 has homeostatic benefits, maintaining immune system regulation and reducing the danger of infection-induced over activity.

Experts believe LL-37 Cap-18 could help control autoimmune inflammation. They assumed it was the source of the inflammation, but new research shows it may be a therapy for autoimmune illnesses [4].

Arthritis

LL-37 cap-18 has been shown to help arthritis. The peptide was found in high concentrations in arthritic joints in rats [5]. Because ll 37 lowered inflammation.

Another study on mice found that LL-37 Cap-18 protects against collagen damage caused by inflammatory arthritis [6]. Direct application of LL-37 to afflicted joints can reduce disease severity. Because LL 37 is abundant in inflamed tissues, scientists assume it has anti-arthritic properties. The peptide also appears to regulate interleukin-32, a molecule linked to arthritis.

There’s additional evidence that toll-like receptor 3 activation exacerbates arthritic symptoms. By binding to TLR4, it can produce anti-inflammatory actions [7].

Lung Disease:

LPS has been detected in several species in clinical trials. When inhaled, this chemical stimulates healthy lung tissue. However, it does not treat respiratory diseases like asthma or COPD. The peptide LL-37 may help treat toxic dust syndrome [8].

According to research findings on LL-37 peptide and lung illness, the peptide enhances epithelial cell proliferation and tissue repair. In addition, drawing pulmonary epithelial cells to the injury site encourages the formation of blood vessels that nourish and maintain the new tissue [9].

Intestinal Cancer:

Studies reveal that the LL-37 peptide may help with stomach and intestinal cancers. While the investigation is currently limited, vitamin D exposure has anti-cancer properties.

Vitamin D boosts the anti-cancer action of intestinal cancers via LL37 [10].

Summary

LL-37 cap-18 is a health-promoting peptide. It induces beneficial reactions in numerous cells throughout the body, including antibiofilm and antibacterial activities.

ll-37 works differently in humans than in animals. Because human trials are conducted on humans, the results of human trials are not comparable.

In LL 37 reviews, people talk about the peptide’s potential effects on the body of mice, which has been studied.

References

  1. https://pubmed.ncbi.nlm.nih.gov/15980359/
  2. https://pubmed.ncbi.nlm.nih.gov/15963694/
  3. https://pubmed.ncbi.nlm.nih.gov/24185823/
  4. https://pubmed.ncbi.nlm.nih.gov/30372860/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137957/
  6. https://pubmed.ncbi.nlm.nih.gov/24091294/
  7. https://pubmed.ncbi.nlm.nih.gov/21708001/
  8. https://pubmed.ncbi.nlm.nih.gov/17655171/
  9. https://pubmed.ncbi.nlm.nih.gov/15964896/
  10. https://pubmed.ncbi.nlm.nih.gov/29843147/
Buy LL-37 Cap-18 Peptide vial 5mg

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Additional information

Weight 0.1 kg
Dimensions 1 × 1 × 1 cm
Size

5mg Vial, Kit = 5mg vial, bac water, syringes