Melanotan 1 Pre-Mixed Pen 10mg

Description

Melanotan 1 Pre-Mixed Pen 10mg

Melanotan 1 is a synthetic peptide that has gained attention for its ability to stimulate the production of melanin, the pigment responsible for skin color. This peptide offers a safer alternative for achieving a desirable tan, as it can be safely combined with UV-B light or sunlight to enhance the tanning response to light.

According to research and clinical trials, Melanotan 1 appears to act synergistically with UV-B light or sunlight, resulting in a more pronounced tanning effect. It works by binding to melanocortin receptors in the skin, triggering the release of melanin and darkening the skin tone. This makes it a popular option for individuals looking to achieve a sun-kissed complexion without prolonged exposure to harmful UV radiation.

In addition to its tanning properties, Melanotan 1 has also been studied for its potential therapeutic uses. It is being explored as a treatment for light-related skin conditions and prevention of skin cancer. Some research suggests that Melanotan 1 may help protect the skin against damage caused by UV radiation, although further studies are needed to fully understand its efficacy in this regard.

Specifications

Sequence: Ser Tyr-Ser Nle-Glu His D Phe-Arg Trp-Gly Lys-Pro Val
Molecular Formula: M78H111N21O19
Molecular Weight: 1646.874 g/mol

Size: 1 Single mixed cartridge | 2 Pre mixed cartridges | 3 Pre mixed cartridges | Pen kit with 1 pre mixed cartridge

Melanotan 1 Research

Sunless tanning

Melanotan 1 Premixed Pen,  in phase one, clinical trials in humans exposed to UV radiation investigated the effect of MT-1 on tanning. MT-1 users browned 75% quicker and got burnt 47% less. On controls, half the amount of UV light was required to provide the same tanning result as the Melanotan 1 pre-mixed pen. They also lived three weeks longer than individuals who were solely exposed to UV light. Scientists believe Melanotan 1 may improve tanning in high UV situations while also guarding against sunburn and long-term UV skin damage. Patients with fair skin may benefit from this (types I and II according to the Fitzpatrick scale) [1].

These individuals are less likely to tan than the ordinary person. However, because Melanotan 1 pre-mixed pen enhances tanning and melanin density, it may help protect those who do not tan and require the most photoprotection [2]. To avoid skin cancer, these persons should apply sunscreen sparingly and stay out of direct sunlight. Skin cancer incidence could be greatly lowered with improved UV protection.

Melanotan-1 can also be used to treat vitiligo. A modest phase 1 experiment discovered that combining Melanotan 1 with UVB light therapy increased both melanin synthesis and melanocyte proliferation. Almost half of the treated individuals showed improved vitiligo pigmentation and faster repigmentation [3].

Combining Melanotan-1 with other vitiligo therapies has been proven to provide synergistic benefits and faster aesthetic outcomes [4]. If Melanotan 1 efficiently treats vitiligo, it could also be utilised to treat hypopigmented scars and other conditions.

Actinic keratosis is a scabby, scaly skin development produced by excessive UV exposure. If left untreated, it will develop into a type of skin cancer (squamous cell carcinoma). Each year, more than 400,000 cases occur. A dermatologist or surgeon can remove visible lesions, but the majority are too small to detect or feel. Melanotan-1 is being investigated as a potential first-line treatment for these undetected lesions and skin cancer prevention.

Weight loss

The Melanotan 1 pre-mixed pen targets the MC5 receptor. MC5R activation increases muscular fatty acid oxidation and converts fat cells from storage to burning [5]. According to these studies in mice, melanocortin activation induces fat burning via numerous receptors and physiologic pathways [6]. For those who are unable to exercise owing to obesity, handicap, or injury, the possibility to improve baseline physiology without exercising is appealing.

Blood pressure

Melanotan 1 pre-mixed pen has been demonstrated to protect against hypertension in hypertensive mice while not influencing normal blood pressure. Existing blood pressure drugs can produce hypotension, which can result in loss of consciousness, heart attack, stroke, and other consequences [7]. Because of their labile physiology, the elderly are more susceptible to this side effect. Melanotan 1’s capacity to manage high blood pressure while avoiding major lows makes it a good option for future medication development.

Heart

Melanotan 1 pre-mixed pen and other melanocortins were found to minimise damage and improve circulatory parameters in heart attack rats. When combined with epinephrine during CPR, MT-1 aids in the restoration of baseline arterial pressure and heart rate, the reversal of metabolic acidosis, the reduction of inflammatory markers, and the improvement of cardiac gene expression. Furthermore, it increased survival by 80%, making it an ideal candidate for emergency advanced cardiac life support [8].

Neuroinflammation

According to studies, the MC1 receptor causes pigmentation in the skin and hair. Many people believed that the receptor’s only job was to bind. However, new research in mice indicate that this receptor is involved in CNS inflammation. Myelin loss on neurons promotes neuron malfunction and even death in multiple sclerosis. Melanotan-1 chemoprevention of neuronal injury in mice was found to help restore myelin and neuron signalling [9].

Acute uveitis in mice causes discomfort and visual loss. Scientists are continually looking for new studies to develop safer alternatives to steroids and immunosuppressive medicines. MT-1 suppresses T-cell activity by mimicking the MC4 receptor. When delivered directly to the eyes, local MC4 receptor agonists work just as well as systemic MC4 receptor agonists. This mode of delivery prevents systemic negative effects [10].

Stroke recovery

MT-1 treatment benefits more than just Alzheimer’s disease biomarkers. Melanotan 1 treatment at nanomolar dosages lowers brain damage, including cell death, while also improving learning and memory recovery in gerbil stroke models. This effect occurs even nine hours after a stroke [11].

Melanotan 1 Pre-Mixed Pen is hypothesised to boost neuroplasticity and aid long-term functional rehabilitation by redirecting memory and learning to healthier brain areas. The Zif268 gene seems to be the key here. Melanotan-1-treated animals have elevated Zif268 levels. The same gene is overexpressed in Alzheimer’s disease models, which enhances cognitive function.

Dementia and cognitive decline

Melanotan 1 pre-mixed pen protects the brain against damage that causes cognitive impairment and Alzheimer’s disease in transgenic mice studies. Even at modest dosages, Melanotan 1 lowers the number of amyloid-beta plaques in the brain, protects neurons from death, improves clinical and laboratory markers of synaptic transmission, and improves clinical cognitive function. Additionally, inhibiting Melanotan 1 pre-mixed at the MC4 receptor reduced the peptide’s positive effects [12].

Other investigations investigated the advantage of Melanotan 1 action on the MC4. Activating the MC4 receptor can improve neurogenesis and cognition in Alzheimer’s disease rats. Some studies demonstrate a slowdown of decline, but this one shows an improvement [13]. Furthermore, MT-1 reduces all AD-related indicators once daily, showing that it acts via many pathophysiological mechanisms [14].

Astrocytes, which protect and nourish neurons, express just the MC4 receptor. Melanotan 1 pre-mixed pen appears to enhance astrocyte function in rats by raising BDNF levels. BDNF maintains synaptic stability and neurogenesis [15].

References

[1] https://pubmed.ncbi.nlm.nih. gov/15262693/

[2] https://pubmed.ncbi.nlm.nih. gov/16293341/

[3] https://pubmed.ncbi.nlm.nih. gov/25230094/

[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5300730/

[5] https://pubmed.ncbi.nlm.nih. gov/17127674/

[6] https://pubmed.ncbi.nlm.nih. gov/21616121/

[7] https://pubmed.ncbi.nlm.nih. gov/23977363/

[8] https://pubmed.ncbi.nlm.nih. gov/25446929/

[9] https://pubmed.ncbi.nlm.nih. gov/27797962/

[10] https://pubmed.ncbi.nlm.nih. gov/21640392/

[11] https://pubmed.ncbi.nlm.nih. gov/19345727/

[12] https://pubmed.ncbi.nlm.nih. gov/25034807/

[13] https://pubmed.ncbi.nlm.nih. gov/26003413/

[14] https://pubmed.ncbi.nlm.nih. gov/24094579/

[15] https://pubmed.ncbi.nlm.nih. gov/25892444/

Buy Melanotan-1 Pre-Mixed Pen 10mg

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