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Mots-c Peptide Nasal Spray


The primary goal of this peptide in its synthetic or natural form is to promote increased growth hormone secretion by inhibiting the action of the enzyme that metabolizes insulin and glucose into glycogen.

15ml Nasal Spray contains 10mg Mots-C Peptide

25ml Nasal Spray contains 20mg Mots-C Peptide

SKU Mots-c Peptide-1 Categories ,


Mots-c Peptide Nasal Spray Description

Mots-C peptide’s primary function is to stimulate growth hormone release by blocking the enzyme that converts insulin and glucose to glycogen.

Mots-c functions similarly to growth hormone releases and is popular with athletes and bodybuilders to help them gain muscle mass and strength.

Notably, Mots-C Peptide nasal spray and growth hormone work by raising the activity of an enzyme that breaks down glycogen and insulin into glucose.

The enzyme breaks down glycogen stored in the liver and pancreas. As a result, the body can turn fat into energy more efficiently when this enzyme’s activity increases.

This suggests that Mots-C Peptide speeds up fat metabolism. In addition, because increasing glucose levels assist the body in losing fat and maintaining muscle mass, they also help the body burn fat faster.

What is Mots-C?

MOTS-c is a mitochondrial-derived peptide that has been found to maintain metabolic balance, reduce obesity, and prevent diabetes in animal studies. This short peptide is part of a broader set of MDPs that experts claim is important in mitochondrial signalling and energy management.

Numerous MDPs are active in the nucleus, new research shows. Moreover, many of them penetrate the bloodstream, causing systemic effects, as revealed in animal testing.

In animal studies, the MOTS-c peptide nasal spray is a newly found MDP linked to metabolism, lifespan, exercise capacity, weight management, and illnesses like osteoporosis and diabetes.

Mots-c Peptide Nasal Spray Research findings

Diabetes and insulin resistance

According to new research from the University of South California, MOTS-C peptide nasal spray prevented the immune system from damaging insulin-producing pancreatic cells. Thus, it prevented type 1 diabetes in mice in the lab.

Diabetes type 1 is a common autoimmune illness that attacks the immune system’s insulin-producing cells in the pancreas.

The peptide MOTS-c assists regulatory T-cells, helping to minimize killer T-cell activation in animal tests [1].

The MOTS c is known to target skeletal muscle. Because it activates the AMPK pathway, it improves insulin sensitivity and glucose absorption in muscle cells without increasing insulin levels in the test animals’ bodies [2].

Besides the USC research, several studies on mice show the importance of MOTSc in the pathophysiology of insulin sensitivity.

The peptide may help scientists monitor pre-diabetic lean mice. They further hypothesize that MOTS-c changes could indicate insulin sensitivity.

While the findings in animal models are encouraging, more clinical trials are required to understand the impacts fully.

Weight loss

Researchers at the Leonard Davis School of Gerontology (USC) revealed MOTS c hormone’s efficiency in preventing weight gain from a high-fat Western diet [3].

MOTS-c was a novel peptide at the time. So scientists were ecstatic to discover it could target muscle tissue and reverse diet-induced insulin resistance in animals.

The team gave MOTS-c injections to obese mice fed a high-fat diet to understand the impacts further. In the MOTS-c peptide nasal spray study, the injection reduced both effects in mice.

The study also found that mots c regulates sphingolipid, monoacylglycerol, and dicarboxylate metabolism. In addition, Mots c prevented fat formation and weight loss in test animals by downregulating these pathways [4].

The relationship between MOTS-C and fat loss has acquired scientific traction. According to a study, a lack of fat oxidation in mitochondria may increase circulating fat, prompting the animal body to increase insulin levels to eliminate fats from the bloodstream.

The animal body develops resistance to increasing amounts of insulin, causing significant fat deposition and homeostatic change.


MOTS-c peptide nasal spray appears to promote longevity in animal studies.

The study found a notable change in the peptide linked to longevity in animal species.

When the MOTS-c gene is altered, it causes the lysine protein to lose a glutamate residue at position 14. Scientists don’t know yet how this alteration affects the protein’s function in animals. However, they are confident because glutamate has distinct characteristics from lysine. Of course, further research is needed to grasp the implications correctly.

The mitochondria are an essential metabolic organelle linked to many age-related illnesses. Mots-c peptides may help extend animal test subjects’ lifespan and improve their general health [5].


Reduced MOTS-c levels in the circulation have been linked to increased endothelial cell dysfunction in animal research subjects undergoing coronary angiography.

Endothelial cells regulate plaque formation, blood pressure, and clotting. MOTS-c peptide nasal spray stimulates endothelial cells, improving mice’s endothelium and blood vessel efficiency [6].

MOTS-C isn’t the only mitochondrial-derived peptide that can improve heart health. At least three MDPs appear to protect heart cells from inflammation and stress.

Thus, MDP dysregulation may play a critical role in initiating cardiovascular disease [7].


A study found that MOTS-c therapy allowed older mice to run longer than untreated mice. So treated mice outperformed untreated mice. This shows MOTS c peptide can improve cellular exercise performance.

The mots-c peptide stimulates osteoblasts in the bone of test animals, resulting in the creation of type I collagen. It did so by regulating the TFG-beta SMAD pathways, which help osteoblasts thrive and survive. So, MOTS-C peptide nasal spray promotes osteoblast survival and thus increases overall bone strength.

The peptide increases the development of bone marrow stem cells via the same route as osteoporosis. This boosted osteogenesis (bone production) as a result.

The research concluded that MOTS-c protects osteoblasts, enhances their health and longevity, and stimulates their production from stem cells.

Increasing research may lead to over-the-counter MOTS c medicine as beneficial prevention and treatment for osteoporosis [8].


  1. https://pubmed.ncbi.nlm.nih.gov/30725119/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185997/
  3. https://gero.usc.edu/2021/08/12/mots-c-mitochondria-type-1-diabetes/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640593/
  5. https://www.sciencedirect.com/science/article/abs/pii/S0891584916302507?via%3Dihub
  6. https://pubmed.ncbi.nlm.nih.gov/29242099/
  7. https://pubmed.ncbi.nlm.nih.gov/31185388/
  8. https://pubmed.ncbi.nlm.nih.gov/31081069/
Buy Mots-C Peptide Nasal Spray 15ml and 25ml

Pharma Lab Global is one of the best locations to purchase high purity Mots-C Peptide Nasal Spray for research. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy Mots-C Peptide and buy Mots-c Pre Mixed peptide from here. Buy Mots-C Peptide Nasal Spray from Pharma Lab Global today!

Mots-c Peptide Specifications

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Weight: 2174.64 f/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

Disclaimer: All products listed on this website and provided through Pharma Labs Global are intended for medical research purposes only. Pharma Lab Global does not encourage or promote the use of any of these products in a personal capacity (i.e. human consumption), nor are the products intended to be used as a drug, stimulant or for use in any food products.

Additional information

Weight 0.01 kg
Dimensions 1 × 1 × 1 cm

15ml, 25ml

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