Oxytocin Nasal Spray
Oxytocin nasal spray is a neuropeptide hormone with therapeutic potential essential for life development. PLG explores oxytocin’s reproductive functions, social bonding, role in social behaviour, and other biological functions.
This peptide has been shown to substantially impact human behaviour and physiology and is vital in partner and child relationships. The hypothalamus secretes this substance into the bloodstream from the pituitary gland in the brain.
Oxytocin nasal spray is vital for father-child bonding and marital trust. In love and healthy sex, couples are generally healthy and happy. Still, when sexual interactions are strained, marital partnerships can become weak.
A recent study from the University of Michigan School of Medicine discovered that giving women oxytocin with a vasoconstrictor reduced their happiness.
Women’s blood vessels do not contract as this peptide fosters a sense of well-being and tranquillity. However, the scientists determined that giving the ladies Oxy and a vasoconstrictor caused a drop in happiness because Oxy worked as a mediator between the two hormones.
This peptide regulates the brain-body connection. The hormone regulates muscle tone, bone density, and fat storage.
This peptide has been shown to support a healthy immune system and mental performance in research. For example, blood pressure, heart rate, and blood sugar are all regulated by oxytocin. In addition, the neuropeptide hormone has been linked to sexual arousal and memory formation.
Molecular Formula: C43H66N12O12S2
Molecular Weight: 1007.2 g/mol
Size: 15ml | 30ml
Early maternal deprivation has long been known to produce lifelong cognitive and behavioural changes. Reduced parental attachment, according to research in mice, alters oxytocin levels. In one experiment, maternally deprived mice treated with oxytocin nasal spray had improved levels of hormones related to prefrontal neuron development .
There was no overall behavioural difference; however, the oxytocin group had improved cognitive performance . Intranasal oxytocin improves learning in stressed mice, but only marginally.
Many studies link oxytocin nasal spray to anxiety and sadness. For example, genetic variants in the oxytocin receptor gene have been related to social anxiety disorder and attachment issues in children. In addition, untreated social anxiety patients showed epigenetic alterations in the oxytocin receptor, suggesting a compensatory strategy for pathologically low oxytocin levels. This indicates that social anxiety is a result of reduced oxytocin signalling .
BPD (Borderline personality disorder) has recently been connected to oxytocin dysregulation. People with BPD have altered non-verbal social behaviour and hypervigilance to hazards. These behaviours have been demonstrated to change with intranasal oxytocin in BPD. For millions of people worldwide, even a small grasp of the pathophysiology that leads to BPD might help researchers improve their lives because BPD is notoriously difficult to treat .
Researchers hypothesized that oxytocin might help protect the heart and vascular system by speeding wound healing and reducing inflammatory cytokines. In addition, anxiety and fat mass can be reduced by taking the peptide and could also be a valuable adjunct to present CVD treatments .
There is also evidence that inhibiting the oxytocin receptor may cause atherosclerosis in specific situations. Conversely, increasing oxytocin levels in persons with low receptor density can protect the heart and reverse atherosclerosis.
In ischemia (heart attack), oxytocin infusion into the heart may preserve cardiomyocytes (heart muscle cells) from apoptosis. In addition, continuous oxytocin nasal spray administration may help train cardiac stem cells to help regenerate tissue via direct differentiation, production of protective and cardiomyogenic factors, and their union with injured cardiomyocytes .
Further research in mice shows that oxytocin can prevent diabetes-related cardiac damage. In these mice, oxytocin reduced body fat growth by 19% and fasting glucose levels by 23%. In addition, it appears to work by reducing insulin resistance. Cardiomyocyte hypertrophy, fibrosis, and death were reduced in mice treated with oxytocin than in controls .
Oxytocin appears to protect from ischemia damage in some tissues but may not be active in the heart. Oxytocin seems to protect from ischemia-reperfusion injury in priapism rats by lowering nitric oxide levels.
Oxytocin nasal spray may help treat diabetes by increasing skeletal glucose absorption and insulin sensitivity. In addition, oxytocin has been shown to reduce total body fat mass and dyslipidemia in mice. Obesity is caused by oxytocin deficiencies even when adequate food consumption and exercise are present, indicating that the peptide is essential in energy balance .
Interestingly, oxytocin administration has no impact on glucose, insulin, or muscle mass in lean mice. In obese mice, it appears to solely impact specific parameters, indicating that while it may help treat some elements of diabetes, that might not be beneficial for all. Oxytocin nasal spray appears to have a distinct impact on diabetes than in healthy people. Patients with diabetes who received intranasal oxytocin lost 9 kg in 8 weeks, lowering blood glucose and insulin levels. A1C and insulin sensitivity are negatively linked with circulating oxytocin, according to Barengolts .
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