PNC-27 Peptide Vial 5mg
PNC-27, is a synthetic peptide which selectively kills cancer cells, thus giving it potential to be used as a cancer treatment. However, PNC-27 is still a research peptide and not yet approved by the FDA for human consumption.
Research has found that the PNC-27 peptide may bind to receptors found on cancer cells to induce cell death. It is a part of the PNC sequence of research proteins intended to repair and induce death by cell necrosis of malformed (cancerous) cells, while keeping normal, healthy cells unharmed, and intact.
The PNC-27 peptide contains a bound HDM-2 domain with a transmembrane-penetrating domain, corresponding to 12-26 residues of p53. This has been demonstrated to allow the peptide to bind and destroy cancer cells by membranolysis or cell membrane disruption.
PNC-27 peptide may prove highly effective in addressing a number of particular types of cancer selectively, including pancreatic cancer, breast cancer, leukaemia, melanoma and additional cancer lines, through testing and studying on animal subjects.
Molecular Formula: C188H293N53O44S
Molecular Weight: 4031.7
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble
In a 2009 study, researchers found that people who took pnc 27 found that the peptide’s p53 residues could be superimposed on the structure for hdm2. As a result, anti cancer peptide PNC-27 can reach the membranes of hdm-2 cancer cells .
Because cancer cells have a lot of HDM in their membranes, PNC-27 can target only the cancerous cells while leaving healthy cells unharmed.
Further evidence found that if they implanted untransformed cells that were not susceptible to pnc27 with hdm2, they would become vulnerable to the peptide. These findings show that the PNC-27 peptide can target HDM-2 membranes in the cancer cell and kill them through membranolysis .
Meanwhile, another study published in 2010 by qualified professionals discovered that PNC-27 killed cancer cells in their entirety rather than in fragments . The researchers were interested in determining whether the pores in the membrane of the cancer cell were formed by portions of the peptide or by the entire peptide. This investigation established that it was the latter.
The researchers discovered that the whole peptide was responsible for the impacts on the cancer cell membrane while the surrounding noncancerous cells remained healthy.
PNC-27 peptide has various benefits in practical outcomes, including lowered pain levels within one week of receiving the peptide. Within three weeks, animal participants exhibit flu-like symptoms, showing that their immune systems respond to killing cancer cells. In addition, bilirubin and lactate dehydrogenase levels increase at the six-week mark.
Significant tumour disintegration and softening of the tumours do not occur until ten weeks. In some situations, the tumour’s site may expand. However, this is related to the inflammatory reaction of the immune system. Scientists report that animal participants exhibit decreased cancer-related symptoms and increased energy levels after three months.
 https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2836618/
 https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC7951797/
 https://pubmed.ncbi.nlm.nih.gov/ 20182728/
Buy PNC-27 Peptide Vial 5mg
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