PT-141 Bremelanotide Peptide Vial 10mg
PT-141 Bremelanotide is a synthetic peptide that increases the production of nitric oxide in the body, thus allowing the blood vessels to open up, increasing the blood flow to the penis, making it more significant, and thus enabling a man to have an erection for longer.
PT 141 will not completely eliminate the feeling of low libido, however it can help treat erectile dysfunction. In addition to improving erectile function it can also be an alternative treatment for female sexual dysfunction.
Bremelanotide, a brand name for PT-141, has been dubbed “the female Viagra” due to its results in treating female hypoactive sexual drive disorder in phase llb human clinical trials (HSDD). PT-141 is a melanocortin that primarily binds to the MC-4R and MC-1R receptors. Acute bleeding may be treated with PT-141, according to research conducted in 2009. Melanotan 2 is another synthetic melanocortin from which PT-141 is derived (MT 2)
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.2 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilize
Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.
PT-141 Bremelanotide is a unique research chemical because it activates the melanocortin receptors, affecting sexual desire and behaviour. Agonist binding to melanocortin receptors induces sexual excitement and enhanced copulation in male and female mice. Because PT-141 works differently than medications like Viagra, it can treat sexual arousal issues in men and women that aren’t caused by diminished genital blood flow .
In those individuals that are unresponsive to sildenafil (Viagra), results showed around one-third of males with ED achieved satisfactory erections for sexual intercourse with PT-141 (administered via nasal spray) with few reported side effects . In addition, the trial showed a robust dose-dependent response, showing that PT 141 is beneficial in some situations. This indicates that PT-141 may offer a potential treatment for erectile dysfunction when sildenafil has been unsuccessful and may help understand the hypoactive sexual drive .
In hypoactive sexual desire disorder sufferers, the drug-enhanced the sexual desire and sexual arousal with very few side effects. Many female sexual dysfunction experts were disappointed to learn that the protein was not being further developed despite promising results. The absence of clear endpoints for FSD trials and cultural preconceptions against females’ sexual health is blamed for the delays .
They expect the FDA to create more specific guidelines for examining potentially useful drugs like PT-141. The expert group was also disappointed that the pharmacological treatments were not combined with other proven approaches to treating sexual dysfunction. In addition, they believe medications like PT-141 Bremelanotide peptide therapy may help overcome initial barriers and initiate psychiatric treatment.
Phase II Reconnect studies using subcutaneous PT141 injections for FSD started in 2017, partly due to discontinued past trials. Rekynda, the newest PT-141 variant, may soon be available in the US. Off-label usage of PT-141 may include male and female sexual problems. These new trials included altered outcomes, which FSD experts think helps approve these medications.
To treat haemorrhagic shock, PT-141 Bremelanotide was slightly modified in 2009. It decreases ischemia and protects tissues from hypovolemic (haemorrhagic) shock by binding to MC-1R and MC-4R molecules. The medication has no significant adverse effects when given intravenously.
Researchers discovered that the MC-1R possesses potent antifungal and anti-inflammatory effects in a rat model of a specific fungal infection. Notably, current antifungals have limited mechanisms of action and induce substantial, treatment-limiting adverse effects in particular individuals. A treatment option for fungal infections could significantly reduce morbidity and death, especially in immunocompromised individuals .
The MC-1R receptor stimulates DNA repair pathways, making it useful in cancer treatment and prevention . People with MC-1R mutations have an increased risk of basal cell and squamous cell carcinoma. Altered PT-141 may offer a viable peptide therapy or prevent malignancies caused by certain variations .
Sexual arousal disorder is currently the focus of most research on PT-141 Bremelanotide. However, its use is not limited to sexual dysfunction or bleeding. Thus, MC-4R deficiency or absence is associated with up to 6% of all cases of early-onset obesity, according to some estimates. PT-141 allows us to investigate this particular cause of obesity and show a possible intervention option. MC-1R is involved in pain, inflammation, kidney disease, and infection dissemination.
 https://pubmed.ncbi.nlm.nih.gov/ 14999221/
 https://pubmed.ncbi.nlm.nih.gov/ 18206919/
 https://pubmed.ncbi.nlm.nih.gov/ 17113634/
 https://pubmed.ncbi.nlm.nih.gov/ 27181790/
 https://pubmed.ncbi.nlm.nih.gov/ 23457491/
 https://pubmed.ncbi.nlm.nih.gov/ 25786343/
 https://pubmed.ncbi.nlm.nih.gov/ 26850723/
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