Sermorelin Peptide Vial

Description

Sermorelin Peptide Vial

Sermorelin is a GHRH analogue used to measure growth hormone levels. It has been shown to strengthen bone density, reduce scarring, fight dementia, and minimise seizure activity. Sermorelin stimulates the pituitary gland to produce the natural growth hormone, and therefore could be used to treat growth hormone deficiency.

Sermorelin is a 29 amino acid bioidentical synthetic growth hormone peptide that has been proven to promote weight loss, aid wound healing, anti-ageing, and muscle growth in animal studies.

Growth Hormones (GH) are less abundant as we get older, so it’s harder to lose weight, look young, and keep muscle mass.
A study on mice revealed that targeted therapies like Sermorelin therapy make rebalancing hormones, improving GH levels and overall health much more manageable.

The mouse body has a complex signalling pathway that helps control and manage cellular activity. Tests have shown that human growth hormone is one of the most powerful anti-ageing treatments. Clinical trials have demonstrated that Sermorelin research chemical can promote fat loss and muscle gain, reduce wrinkles, promote skin elasticity, and improve mouse concentration by optimising human growth hormone levels.

Specifications

Molar mass: 3357.882 g/mol g·mol−1
Formula: C149H246N44O42S

Sermorelin Peptide Vial Size: 2mg | 5mg

Research

Sermorelin is a growth hormone releasing hormone derivative that increases muscle mass, promotes the growth of long bones, and reduces fat tissue resulting in an improved body composition. The effects are identical, but the side effects are not. In humans, Sermorelin is therefore preferred to exogenous growth hormone treatment.

The main reason is that sermorelin is sensitive to physical feedback processes that help prevent common GH administration problems.  [1].

It also does not cause tachyphylaxis, where the body has become used to the medication and requires increasing doses to obtain the intended effects. Tachyphylaxis can be so intense that a drug holiday (complete cessation of medication) is needed to regain its impact. According to clinical studies and animal studies, Sermorelin has a unique response in the body.

Rather than decreasing growth hormone releasing hormone receptor production, sermorelin increases it. This keeps sermorelin’s effects the same, prevents tachyphylaxis, and reduces the need for dose escalation [2].

Sleep effects:

Orexin, a powerful neurochemical generated by specific brain neurons, appears to regulate sleep cycles. We also know that growth and healing, closely linked to growth hormone secretion, occur primarily during sleep. The GHRH axis is required for adequate orexin secretion and function in rainbow trout research. Exogenous sermorelin and other GHRH agonists can also boost orexin secretion [3]. Clinical investigations into Sermorelin’s benefits for sleep disorders are still continuing.

Cardiac effects:

A heart attack can cause long-term disability due to cardiac arrhythmias, heart failure, pain, reduced exercise capacity, and other factors. Many of these issues stem from cardiac remodelling caused by myocyte damage (heart muscle cells). Cardiac remodelling often causes scarring in the damaged and unaffected areas surrounding a heart attack. This remodelling causes long-term issues, and studies show that preventing it can improve outcomes immediately and years later. For example, a 2016 pig study found sermorelin effectively reduces post-heart attack remodelling. Sermorelin reduces cardiomyocyte cell death, increases the production of extracellular matrix components needed for healing, increases blood vessel growth to damaged tissue, and reduces damaging inflammation.

In clinical studies, sermorelin promotes less scar tissue and more capillary growth [4], [5]. In addition, other areas of heart health including heart disease, such as heart failure and valve disorders, are currently being researched.

Epilepsy effects:

GABA (Gamma-aminobutyric acid) is a CNS (central nervous system) signalling compound that reduces spinal cord electrical activity and overall central nervous system excitability. Many anti-seizure drugs work by increasing GABA levels in the brain or binding to GABA receptors and mimicking its effects. Researchers recently gave epileptic mice GHRH analogues like sermorelin to see how these peptides affected seizure activity. GHRH analogues suppress convulsions by activating GABA receptors [6]. This is a discovery and an active research area because medications for treating seizures have various adverse side effects that limit their clinical use.

Summary

People unable to build appropriate lean muscle mass during and after puberty frequently utilize Sermorelin growth hormone therapy.

This hormone is primarily administered to patients with growth hormone deficiencies. A shortage in GH levels increases the risk of osteoporosis, diabetes, and other degenerative disorders. It aids in the creation of energy and regulates body temperature. Additionally, it possesses anti-ageing and anti-disease qualities.

Numerous investigations have discovered that Sermorelin and Growth Hormone can increase growth. However, further studies are required on the way in which Sermorelin works, but in many areas sermorelin administration could hold potential as a new therapeutic approach.

References:

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2699646/

[2] https://pubmed.ncbi.nlm.nih.gov/ 11888834/

[3] https://pubmed.ncbi.nlm.nih.gov/ 17240179/

[4] https://pubmed.ncbi.nlm.nih.gov/ 25827134/

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4496393/

[6] https://pubmed.ncbi.nlm.nih.gov/ 29273763/

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