Elamipretide (SS-31)

Description

Elamipretide SS-31 50mg

The SS-31 provides various advantages: the ability to target and accumulate on the inner membrane of mitochondria, the ability to protect it against mitochondrial depolarisation, and the ability to be a small water-soluble peptide.

Elamipretide SS-31 50mg can enter the mitochondria and impact mitochondrial function maintenance.

A neuron’s ability to operate and survive is directly influenced by the activity of its mitochondria [1]. During apoptosis, mitochondria play a vital role in energy transfer from the cell’s intracellular to extracellular compartments [2].

Elamipretide has been shown to positively affect mitochondrial function and maintenance; thus, it is being studied to see if it can improve human health. Recent discoveries by scientists have revealed at least four good benefits that may make elamipretide a feasible therapy option in the future for a wide range of conditions:

• Physical endurance can be improved with Elamipretide use.
• It has been shown that Elamipretide can help those with cognitive difficulties.
• Preventing Cardiovascular Disease Risk with Elamipretide.
• It is Possible to Treat Mitochondrial Dysfunction With Elamipretide

Elamipretide SS-31 50mg Research findings

Physical endurance

The mitochondria are responsible for human physical activity and endurance. That is, human survival depends on mitochondrial energy production. As a result, patients with mitochondrial dysfunction may suffer from severe fatigue and require medicine to improve mitochondrial activity.

An 8-week study found elamipretide to be beneficial in elderly mice. Elamipretide improves skeletal muscle function and exercise tolerance by restoring cellular redox balance. However, a shift in redox homeostasis in elderly muscles is also linked to energy shortages and exercise intolerance [3].

Recognizing elamipretide’s benefits on physical endurance, researchers are testing it for treatment of Barth Syndrome, a condition characterized by skeletal muscle weakness and physical impairment. Twelve weeks of daily elamipretide injections relieved Barth Syndrome and specific heart problems [4].

Aside from treating illnesses like Barth Syndrome, elamipretide can help the elderly maintain their independence and improve their quality of life by slowing down the ageing process. In addition, Elamipretide’s effects on physical endurance are anticipated to translate from animal research to human use.

Cognitive effects

The proper functioning of the brain’s blood supply is critical to its overall health. However, mitochondrial oxidative stress contributes to cognitive decline as we age. Therefore, researchers carried out a study to learn whether or not treating mitochondrial oxidative stress with the drug elamipretide has any positive effects on cognition.

Treatment with elamipretide boosted cerebral blood vessel dilatation considerably in a 2-week trial on aged mice [5], which was linked to improved working memory and motor skill development. According to the findings, elamipretide may be used to prevent or treat cognitive decline associated with ageing.

Prevention of cardiovascular disease

Elamipretide can reduce the risk of cardiovascular disorders, particularly diastolic dysfunction, an age-related heart ailment. Diastolic dysfunction is caused by the hardening of the heart’s ventricles.

In an 8-week research, elamipretide significantly reversed diastolic dysfunction in aged mice by regulating proton leak and lowering mitochondrial reactive oxygen species in heart muscle cells [6]. The study concluded that addressing mitochondrial dysfunction could reverse age-related heart problems.

Elamipretide has good potential; however, it is still being studied. If the effects of this peptide are consistent in human trials, it may be an additional therapy option for numerous health issues.

Mitochondrial dysfunction

Cellular energy production is impaired due to mitochondrial dysfunction, which causes mitochondrial degeneration and many other disorders. Elamipretide can be used to treat mitochondrial dysfunction because of its regeneration properties on the inner mitochondrial membrane, resulting in numerous positive consequences [7].

Elamipretide specifically stabilizes the inner mitochondrial membrane, which prevents mitochondrial decline, increasing mitochondrial performance. Elamipretide can boost cellular energy production since the mitochondria are essential to the human body and are responsible for manufacturing cellular energy.

Elamipretide has improved physical endurance in patients with diseases connected to exercise intolerance by enhancing energy production, as scientists have recognized this chain of favourable events.

Elamipretide SS-31 50mg Peptide summary

Elamipretide is a new tetrapeptide medication that binds to cardiolipin, improving mitochondrial functions such as ATP synthesis, membrane potential, calcium flux and reducing superoxide production.

References

1. https://pubmed.ncbi.nlm.nih.gov/29391029/
2. https://pubmed.ncbi.nlm.nih.gov/21321998/
3. https://pubmed.ncbi.nlm.nih.gov/26820564/
4. https://www.nature.com/articles/s41436-020-01006-8
5. https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12731
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377906/
7. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1627-9

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Elamipretide SS-31 50mg Specifications

Sequence: d-Arg-Dmt-Lys-Phe-NH₂
Molecular Formula: C32H49N9O5
Molecular Weight: 639.8 g/mol

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