SS-31 Elamipretide Nasal Spray

Description

SS-31 Elamipretide Nasal Spray

SS-31 Elamipretide is a mitochondria-targeted peptide that has shown potential in improving and preventing various age-related functional ailments. Clinical trials have demonstrated its ability to attenuate age-associated heart dysfunction and improve mitochondrial dysfunction, synaptic impairment, and memory impairment induced by lipopolysaccharide.

Furthermore, scientists suggest that Elamipretide may improve cognitive dysfunction and inflammatory responses in the hippocampus. While further research is needed to fully understand its mechanisms and potential therapeutic applications of SS-31 Elamipretide, these findings highlight the potential health benefits of the peptide in addressing age-related conditions.

SS-31 provides various key advantages including the ability to target and accumulate on the inner membrane of mitochondria, the ability to protect it against mitochondrial depolarisation, and the fact it is a small water-soluble peptide. Elamipretide SS-31 can enter the mitochondria and impact mitochondrial function maintenance.

Specifications

Molecular Formula: C32H49N9O5

Molecular Weight: 639.8 g/mol

Sequence: d-Arg-Dmt-Lys-Phe-NH2

Size: 15ml | 30ml

Research

Physical endurance

A neuron’s ability to operate and survive is directly influenced by the activity of its mitochondria [1]. Moreover, during apoptosis, mitochondria have a key role in energy transfer from the cell’s intracellular to extracellular compartments [2]. The mitochondria are responsible for physical activity and endurance in the human body. That is, human survival depends on mitochondrial energy production. As a result, patients with mitochondrial dysfunction may suffer from severe fatigue and require medicine to improve mitochondrial activity.

In an eight week study elamipretide was found to be beneficial in elderly mice. Results found that Elamipretide SS-31 improved skeletal muscle function and the tolerance to exercise by restoring cellular redox balance. However, a shift in redox homeostasis in elderly muscles is also linked to energy shortages and exercise intolerance [3].

In recognizing elamipretide’s benefits on physical endurance, researchers investigating the peptide as a potential treatment of Barth Syndrome, a condition characterized by skeletal muscle weakness. During studies twelve weeks of daily elamipretide injections relieved Barth Syndrome and some heart problems [4].

Aside from having the potential to treat illnesses like Barth Syndrome, SS-31 could help the elderly maintain their independence and improve their quality of life by slowing down the ageing process.

Cognitive effects

The brain’s proper blood supply functioning is critical to its overall health. However, mitochondrial oxidative stress contributes to cognitive decline as we age. Therefore, researchers carried out a study to learn whether or not treating mitochondrial oxidative stress with the drug ss-31 elamipretide nasal spray has any positive effects on cognition.

They discovered that treatment with elamipretide boosted cerebral blood vessel dilatation considerably in a two week trial on aged mice [5], which resulted in improved working memory and fine motor skill development. This suggests that elamipretide may be used to prevent or treat ageing-related cognitive decline.

Prevention of cardiovascular disease

Elamipretide can reduce the risk of cardiovascular disorders, particularly diastolic dysfunction, an age-related heart ailment. Diastolic dysfunction is caused by the hardening of the heart’s ventricles.

In an 8-week study, ss-31 elamipretide nasal spray significantly reversed diastolic dysfunction in aged mice by regulating proton leak and lowering mitochondrial reactive oxygen species in heart muscle cells [6]. The study concluded that addressing mitochondrial dysfunction could reverse age-related heart problems.

Mitochondrial dysfunction

Cellular energy production is impaired due to mitochondrial dysfunction, which causes mitochondrial degeneration and many other disorders. It is thought that SS-31 Elamipretide nasal spray can be used to treat mitochondrial dysfunction because of its regeneration properties on the inner mitochondrial membrane, resulting in numerous positive consequences [7].

Elamipretide stabilizes the inner mitochondrial membrane, preventing mitochondrial decline and increasing mitochondrial performance. Elamipretide can boost cellular energy production since the mitochondria are essential to the human body and are responsible for manufacturing cellular energy.

Elamipretide has improved physical endurance in patients with diseases connected to exercise intolerance by enhancing energy production, as scientists have recognized this chain of favourable events.

Summary

SS-31 Elamipretide, a mitochondrial-targeted peptide, has various potential health benefits. According to research, restoring redox equilibrium in cells can improve skeletal muscle performance and increase exercise capacity. Elamipretide has also showed promise in treating age-related cognitive decline by improving mitochondrial and synaptic function and decreasing oxidative stress and neuroinflammatory responses.

Furthermore, this peptide has been shown to improve functional connectivity in the hippocampus and protect mitochondria in circumstances like metabolic syndrome. These findings show SS-31 Elamipretide’s potential to address a variety of age-related problems while also boosting mitochondrial function. However, more research is required to completely understand its effectiveness and safety.

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 29391029/

[2] https://pubmed.ncbi.nlm.nih.gov/ 21321998/

[3] https://pubmed.ncbi.nlm.nih.gov/ 26820564/

[4] https://www.nature.com/articles/ s41436-020-01006-8

[5] https://onlinelibrary.wiley.com/ doi/full/10.1111/acel.12731

[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7377906/

[7] https://jneuroinflammation.bio medcentral.com/articles/10.1186/ s12974-019-1627-9

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