Tesamorelin Peptide Vial

Description

Tesamorelin Peptide Vial

Tesamorelin is a lipophilic peptide that has been clinically tested to be effective in removing fat from the abdominal area. It was initially used in the treatment of lipodystrophy in patients with HIV. It is also being studied for its ability to reduce body fat in those with obesity.

Lipodystrophy is the medical term used for increased body fat found in specific areas of the abdomen, hips, and pelvis. When lipodystrophy is present in a person, the skin around the body tends to become loose and saggy, causing a waxy, bumpy appearance to occur around the body. The most common areas affected by lipodystrophy are the thighs, hips, and abdomen. Lipodystrophy can cause a wide variety of symptoms ranging from fatigue, anxiety, irritability, weight gain, and chronic pain.

For those suffering from excessive abdominal fat, lipodystrophy can cause serious health complications and health problems.

Specifications

Molecular Formula: C221H366N72O67S
Sequence: Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2
Molecular Weight: 5136 g/mol
Physical Appearance: White Lyophilised Solid
Solubility: Water Soluble

Size: 2mg | 5mg | 10mg

Research

Fat loss

Tesamorelin stimulates the pituitary gland to release GHRH, which increases lipolysis. Lipolysis is the breakdown of triglycerides and lipids to produce fat loss.

Lipids and triglycerides are fats found in the body stored for energy. High levels of either can increase your risk of ailments, including heart disease.

Clinical trials have found that Tesamorelin works by reducing visceral fat. In trials, mice given tesamorelin for weight loss lost 15% of their weight in 26 weeks [1].

Another   2014 study found tesamorelin reduced liver fat by 18%. The test mice got tesamorelin injected under their naval once a day.

Lypodystrophy

Tesamorelin is primarily used to treat HIV-associated lipodystrophy, which occurs due to both HIV infection and antiretroviral therapy. Lipodystrophy causes excess fat accumulation in the abdomen and elsewhere. The physiologic mechanism is unknown; however, it is suspected that protease inhibitors play a substantial role in lipodystrophy aetiology [2].

Lipodystrophy patients were initially treated with diet, exercise, and some unsuccessful medicines. Surgery was a last resort if those failed, typically futile and complicated. The FDA authorized tesamorelin for HIV-associated lipodystrophy in 2010. The medication reduces adiposity by about 20% in this population [2]. Tesamorelin appears four times more effective than all other known medications in lowering adiposity [3].

HIV and Growth Hormone deficiency

Scientific research links HAART to endocrine and metabolic issues, including GH insufficiency. Because HIV alters the pituitary gland, roughly one-third of people on HAART suffer growth hormone deficiency [4]. This may answer how lipodystrophy is widespread in HIV patients and why tesamorelin is so effective as a therapy. Tesamorelin is a safe and effective alternative to exogenous GH, especially for HIV-positive people.

Heart Disease

HIV-positive people are more prone to cardiovascular disease due to excessive fat deposition and partly to antiretroviral medications activities. After highly active antiretroviral therapy (HAART), cardiovascular disease prevention is regarded as the most significant medical intervention for long-term well-being in HIV-positive people. Statins were the foundation of medical care until recently.

Tesamorelin decreases triglycerides, total cholesterol, and non-HDL-C in HIV-positive patients and lowers lipodystrophy. In addition, Tesamorelin reduces visceral adipose tissue by 15% and triglyceride levels by 50 mg [5].

Notably, ectopic fat accumulation in lipodystrophy is linked to inflammation. Inflammation is a CVD risk factor. Visceral, hepatic, and epicardial fat are all related to a higher risk of CVD. The peptide reduces inflammation and reduces CVD risk by lowering ectopic fat deposition.

Nerve Damage

Injury, diabetes, or surgery can cause peripheral nerve damage; however, little can be done to rectify the condition because nerve cells are notoriously difficult to regenerate. However, research suggests that growth hormone manipulation therapy may improve peripheral nerve damage repair and speed [6]. This peptide is now the frontrunner for such an intervention, partly due to FDA approval.

Dementia

There is currently evidence that GHRH analogues, including Tesamorelin, can improve cognitive function in patients with early dementia [7]. For example, one study found that using Tesamorelin or other GHRH analogues for 20 weeks increased GABA levels in the brain while lowering MI levels. These discoveries provide new areas for scientists to study in search of a cure or prophylactic.

Summary

Tesamorelin is a synthetic peptide known for its ability to reduce belly fat in HIV patients who have lipodystrophy, a condition that includes changes in body fat distribution. It does this by mimicking the natural growth hormone-releasing hormone (GHRH) in the body, stimulating the pituitary gland to produce more growth hormone. This hormone plays a key role in regulating body composition, body fluids, muscle and bone growth, sugar and fat metabolism. Moreover, Tesamorelin has been to be an effective treatment when improving cognitive function in older adults with mild cognitive impairment.

References

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4363137/

[2] https://www.ncbi.nlm.nih.gov/ books/NBK539131/

[3] https://pubmed.ncbi.nlm.nih.gov/ 26457580/

[4] https://pubmed.ncbi.nlm.nih.gov/ 28477736/

[5] https://pubmed.ncbi.nlm.nih.gov/ 22495074/

[6] https://pubmed.ncbi.nlm.nih.gov/ 27192539/

[7] https://pubmed.ncbi.nlm.nih.gov/ 23689947/

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