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Triptorelin (GnRh)

£16.99£24.64

Research has suggested Triptorelin is used to enhance fertility in adults.

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Description

Triptorelin GnRH Peptide Vial 2mg

Triptorelin is a peptide which is taken for the treatment of fertility problems. The peptide is a combination of two peptides – Gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH). The pituitary gland secretes this hormone in the brain. It is responsible for regulating the ovulation cycle.

With an abnormal production of this hormone in the ovaries, there is a problem with the ovulation process. This then causes infertility as the egg will not be released during ovulation and the woman will be unable to conceive. Sometimes the ovaries produce too much gonadotropin-releasing hormone in one ovary or in several ovaries, which may also lead to infertility.

Triptorelin GnRH Research findings

Triptorelin Increases Testosterone in Some Men

How triptorelin is used can vary its effects. Triptorelin GnRH has been demonstrated to boost testosterone levels early in long-term administration and only begins to inhibit production after repeated exposure. A testosterone flare occurs during the first few weeks of treatment with triptorelin. This implies triptorelin may enhance testosterone levels in some men if appropriately provided.

Triptorelin Effects

Triptorelin is an analogue of GnRH (Gonadotropin-Releasing Hormone) that can stimulate the anterior pituitary gland to release hormones FSH and LH. Triptorelin does this when pulsed. The magnitude and frequency of GnRH pulses and triptorelin dosage determine FSH and LH levels.

If triptorelin is given steadily rather than pulsatile, it will reduce LH and FSH secretion and testosterone and oestrogen production. How triptorelin is used in study determines its qualities.

Most triptorelin research focuses on long-term use to inhibit sex hormones. Most of this research focuses on oncology and sex hormones in cancer. Triptorelin may restore sexual function, fertility, and testosterone levels; however, data is preliminary.

Breast cancer triptorelin research

Triptorelin is being studied as a tamoxifen substitute and adjuvant. In phase 3 clinical trial, triptorelin combined with zoledronic acid or letrozole reduced disease-free 5-year survival rates in premenopausal women more than tamoxifen [1].

Adding triptorelin to tamoxifen improves disease management and survival, especially in high-risk patients who have already taken chemotherapy [2]. The potential to improve the efficacy and duration of hormone therapy for breast cancer has made triptorelin GnRH research a prominent topic.

Prostate Cancer Treatment with Triptorelin

Triptorelin reduces prostate cancer growth by lowering testosterone levels. Triptorelin improves the 10-year mortality rate in hormone-sensitive prostate cancer to under 5%. In addition, it reduces surgery [3]. Triptorelin has helped most men live longer with prostate cancer. Combining triptorelin with other treatments may increase its benefits.

Triptorelin GnRH plus radiation therapy appears to be equally effective as total androgen blockade [4]. Many men find the adverse effects of total androgen blocking unacceptable. Minimizing side effects while maintaining efficacy can enhance the quality of life and treatment adherence.

Triptorelin may also help reduce lower urinary tract symptoms in males with prostate cancer, lowering severe symptoms from 54% to 16% weekly [5]. Similar studies in China, Belgium, and South Korea verified these results [6]. These findings suggest that triptorelin may effectively treat BPH and other diseases that affect male urine function.

Triptorelin could treat one of the most severe and life-altering symptoms of prostate cancer.

Triptorelin safeguards fertility

Chemotherapy can cause infertility in younger patients. However, small clinical research found that triptorelin helps sustain fertility in some young women receiving chemotherapy [7]. Triptorelin has also been shown to delay the onset of early menopause in chemotherapy patients by around 17% [8].

Triptorelin improves fertility in more than simply chemotherapy patients. Triptorelin medication can boost spontaneous pregnancy chances in women with adenomyosis [9]. Endometriosis sufferers also benefit.

Endometriosis and Triptorelin Research

Research reveals triptorelin gnrh reduces endometriosis discomfort and reduces nodule volume. This may make triptorelin an effective pre-surgical therapy to minimise bleeding and other complications in endometriosis surgery [10]. Preliminary research reveals triptorelin gnrh can improve laparoscopic endometriosis surgery.

It is highly successful in terms of post-operative pregnancy rates [11]. In a three month clinical trial, triptorelin reduced pain in 80% of endometriosis patients and diarrhoea in 60%. Triptorelin does not cure endometriosis but manages it. Future studies on the peptide may find permanent cures for endometriosis.

Triptorelin and Immune Function Research

Rat studies show that LHRH directly affects the thymus and controls a crucial part of the immune system. Ageing reduces the number of places on the thymus where LHRH agonists can bind. This, in turn, causes the thymus mass to drop by 50 per cent over time. This results in your immune system being less effective as you age and making you more likely to get colds and the flu.

It has been shown that giving an LHRH agonist like triptorelin gnrh makes the thymus grow faster and reverses some of the effects of getting older [12]. Some people think that taking triptorelin supplements could help stop the changes in thymic mass that come with getting older. This would make the immune system work better. The peptide could be used both to treat and prevent diseases.

References

  1. https://pubmed.ncbi.nlm.nih.gov/31164265/
  2. https://pubmed.ncbi.nlm.nih.gov/29177573/
  3. https://pubmed.ncbi.nlm.nih.gov/27246172/
  4. https://pubmed.ncbi.nlm.nih.gov/29715154/
  5. https://pubmed.ncbi.nlm.nih.gov/29789236/
  6. https://pubmed.ncbi.nlm.nih.gov/26161142/
  7. https://pubmed.ncbi.nlm.nih.gov/29620680/
  8. https://pubmed.ncbi.nlm.nih.gov/21771987/
  9. https://pubmed.ncbi.nlm.nih.gov/31067498/
  10. https://pubmed.ncbi.nlm.nih.gov/24832495/
  11. https://pubmed.ncbi.nlm.nih.gov/30344551/
  12. https://pubmed.ncbi.nlm.nih.gov/2546733/
Buy Triptorelin GnRH Peptide vial 2mg

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Triptorelin GnRH Specifications

Molecular Formula: C64H82N18O13
Sequence: H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2
Molecular Weight: 1311.4 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

Disclaimer: All products listed on this website and provided through Pharma Labs Global are intended for medical research purposes only. Pharma Lab Global does not encourage or promote the use of any of these products in a personal capacity (i.e. human consumption), nor are the products intended to be used as a drug, stimulant or for use in any food products.

Additional information

Weight 0.01 kg
Dimensions 1 × 1 × 1 cm
Size

2mg Vial, Kit = 2mg vial, bac water, syringes

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