HGH Frag 176-191 Pre Mixed Pen 5mg

Description

HGH Frag 176-191 Pre Mixed Pen 5mg

HGH Frag 176-191 Pre-Mixed Pen 5mg (a modified variant of AOD9604) is a human growth hormone (hGH) lipolytic fragment. This term was given to Fragment 176-191 because it has been demonstrated to improve fat burning in experimental mice with significant fat deposits.

While HGH Frag 176-191 pre-mixed Pen retains hGH’s fat-burning benefits, it does not stimulate IGF-1, have a negative influence on carbohydrate metabolism, alter insulin sensitivity, or increase long bone growth. Because of the unique properties of segment 176-191, it can be utilised to investigate human fat metabolism and possibly produce anti-obesity medications.

Specifications

Molecular Formula: C78H125N23O23S2

Sequence: Tyr-Leu-Arg-IIe-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Molecular Weight: 1817.12 g/mol

Size: 1 Single mixed cartridge | 2 Pre mixed cartridges | 3 Pre mixed cartridges | Pen kit with 1 pre mixed cartridge

Research

Regulating Blood Sugar

Through scientific research we know that the c terminal end of hGH is responsible for its hypoglycemic (blood sugar lowering) actions in animals. For reducing blood sugar levels, 176-191 is the most effective synthetic derivative. Secondary to an increase in plasma insulin levels[1].  HGH fragment 176-191 could be used to treat prediabetes and type 2 diabetes.

Fat Loss And Fat Burning

This “Lipolytic fragment” peptide has been found to burn fat and reduce body weight in mice. B3-AR (or ADRB3) production is thought to be involved in increasing skeletal muscle thermogenesis and adipose tissue fat burning. Conversely, mice lacking ADRB3 do not benefit from hGH or fragment 176-191.

A three-week study demonstrated a higher fat reduction related to fragment 176-191 correlates with an increased energy expenditure and weight loss [2]. When exposed to fragment 176-191 [3], only obese mice lost weight, while thinner mice did not. To research energy homeostasis, scientists can use secondary regulatory pathways for lipolysis instead of ADRB3.

Promotes Cartilage Renewal

Alhouugh HGH Frag 176-191 peptide is primarily studied for its lipolytic properties, other potential benefits are still being investigated.

For example, the Korean study found that fragment 176-191 could enhance the impacts of hyaluronic acid injections in boosting cartilage regeneration. Weekly injections of fragment 176-191 increased laboratory measures of cartilage growth in rabbits, and co-administration of the peptide with hyaluronic acid (HA) increased effects even further.

Similarly, fragment 176-191, alone or in conjunction with HA, reduces osteoarthritis disability. This may lead to advanced osteoarthritis therapies and even minimize the need for surgery in some cases [4].

Summary

HGH Frag 176-191 Pre-Mixed Pen 5mg is being studied in the field of weight reduction and lipolysis to better understand energy homeostasis and fat metabolism. Connective tissue regeneration, in particular cartilage repair, is the most active secondary area of research.

Although the effects of HGH Frag 176-191 Pre-Mixed Pen 5mg has been studied primarily on animals, it has been proven to retain HGH’s fat-burning properties. Additionally, it has been found not to increase IGF-1 levels, negatively impact carbohydrate metabolism, alter insulin sensitivity, or increase long bone development.

A study published in the 2013 Journal of Endocrinology and Metabolism analysed six trials of HGH Frag 176-191 Pre-Mixed Pen, its purpose to assess the rate and magnitude of possible side effects. It found that HGH Fragment 176-191 did not affect glucose tolerance, insulin sensitivity, or IGF-1 levels compared to a placebo. This demonstrates that HGH fragment 176-191 provides many of the benefits of hGH without the unfavourable side effects [5].

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 645904/

[2] https://pubmed.ncbi.nlm.nih.gov/ 11713213/

[3] https://pubmed.ncbi.nlm.nih.gov/ 11146367/

[4] https://pubmed.ncbi.nlm.nih.gov/ 26275694/

[5] https://journals.physiology.org/ doi/abs/10.1152/ajpendo.1978. 234.5.E521?journalCode=ajpendo

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