KPV

Description

KPV Peptide Vial 2mg

KPV is a powerful anti-inflammatory peptide that has demonstrated potential for treating various diseases. The peptide has shown the most promise in treating inflammatory bowel disease, where research is most intense. In addition, research on wound healing suggests alpha-MSH derivatives including KPV may offer various benefits that reduce infection, combat inflammation, speed up wound healing, and enhance cosmetic outcomes. KPV and similar peptides may become crucial for scar reduction and wound healing after surgery.

What is KPV?

Alpha-MSH derivatives including KPV have also been linked to improved wound healing, infection reduction, inflammation reduction, and improved cosmetic outcomes in studies on wound healing. So when it comes to scar reduction following surgery, KPV and similar peptides could become a staple.

KPV is an alpha-melanocyte-stimulating hormone’s C-terminal peptide fragment (alpha-MSH). Many short alpha-MSH derivatives have been studied to identify if they possess the same activity against ischemia, sexual effects, photoprotective properties, or energy homeostasis and benefits on feeding behaviour as alpha-MSH.

Lysine-proline-valine (KPV), a combination of these three amino acids, has powerful anti-inflammatory properties. KPV is being researched as a potential therapy for inflammatory bowel disease. As mentioned above, anti-inflammatory characteristics have been indicated in the gastrointestinal tract, central nervous system, vascular system, lungs and joints of the organs.

Specifications

Sequence: Lys-Pro-Val

Molecular Formula: C16H3oN4O4

Molecular Weight: 342.43 g/mol

Size: 2mg

Research

Intestines

In decreasing intestinal inflammation, KPV is the most important. In mice models of inflammatory bowel disease (IBD), this compound lower inflammatory infiltrates, MPO activity, and overall histological signs of inflammation. This peptide improved the rate of recovery and increased body weight in mice. The delivery of this C-terminal peptide fragment (alpha-MSH) using nanoparticles functionalized with hyaluronic acid assists in directing the virus’s inflammatory properties to specific intestinal sites. Thus, inhibiting TNF-alpha lowers inflammation and promotes the repair of the mouse mucosa.

NF-kappaB and mitogen-activated protein kinase (MAPK) are likewise inhibited by the peptide, according to studies. Inhibition of TNF-alpha, NF-kappaB, and MAPK ameliorates intestinal inflammatory alterations. Compared to control mice, mice with KPV have shorter colons and less colonic infiltration.

Anti-inflammatory

The peptide causes inflammatory effects without the pigmentation generally associated with natural scar development. In addition, KPV contains anti-inflammatory and antimicrobial properties. It stops the growth of Candida albicans and Staphylococcus aureus and helps keep burns and other serious wounds from getting infected. The advantage of the peptide is in comparison to other anti-inflammatory medicines, which hinder the body’s capacity to fight infection.

Scarring

KPV can reduce chronic inflammation, which is responsible for hypertrophic scarring (e.g., keloid). It is brought on by extensive macrophage infiltration, TNF immunoreactivity, and neutrophil abundance. Using alpha-MSH in this context results in less severe scarring and inflammation. These results suggest that this peptide could be used to prevent the scarring caused by some chemotherapeutic drugs. This method would not only lessen the bad side effects of cancer treatments but also make it easier to use higher quantities of these medications to get better results.

Summary

This peptide has shown several benefits in the medical field, including:

• Reduces inflammation in the intestines.
• A general anti-inflammatory.
• Helps reduce fever.
• Accelerates wound healing.
• Stops hypertrophic scars from forming
• Unlike the parent molecule, alpha-Melanocyte Stimulating Hormone, it does not result in skin pigmentation.

References

1. https://pubmed.ncbi.nlm.nih.gov/18061177/
2. https://pubmed.ncbi.nlm.nih.gov/2550304/
3. https://pubmed.ncbi.nlm.nih.gov/10670585/
4. https://pubmed.ncbi.nlm.nih.gov/25431356/

Buy KPV Peptide vial 2mg

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