KPV Peptide Vial

Description

KPV Peptide Vial 2mg

Alpha-MSH derivatives including KPV have also been linked to improved wound healing, infection reduction, inflammation reduction, and improved cosmetic outcomes in studies. So when it comes to scar reduction following surgery, KPV and similar peptides could become a staple.

KPV is an alpha-melanocyte-stimulating hormone’s C-terminal peptide fragment (alpha-MSH). Many short alpha-MSH derivatives have been studied to identify if they possess the same activity against ischemia, sexual effects, photoprotective properties, or energy homeostasis and benefits on feeding behaviour as alpha-MSH.

Lysine-proline-valine (KPV), a combination of these three amino acids, has the powerful ability to reduce inflammation. KPV is being researched as a potential therapy for inflammatory bowel disease. As mentioned above, anti-inflammatory characteristics have been indicated in the gastrointestinal tract, central nervous system, vascular system, lungs and joints of the organs.

Specifications

Sequence: Lys-Pro-Val

Molecular Formula: C16H3oN4O4

Molecular Weight: 342.43 g/mol

Size: 2mg

KPV Research

Intestines

In decreasing intestinal inflammation, KPV is the most important. In mice models of inflammatory bowel disease (IBD), this compound lower inflammatory infiltrates, MPO activity, and overall histological signs of inflammation. This peptide improved the rate of recovery and increased body weight in mice. The delivery of this C-terminal peptide fragment (alpha-MSH) using nanoparticles functionalized with hyaluronic acid assists in directing the virus’s inflammatory properties to specific intestinal sites. Thus, inhibiting TNF-alpha lowers inflammation and promotes the repair of the mouse mucosa.

NF-kappaB and mitogen-activated protein kinase (MAPK) are likewise inhibited by the peptide, according to studies. Inhibition of TNF-alpha, NF-kappaB, and MAPK ameliorates intestinal inflammatory alterations. Compared to control mice, mouse models with the peptide have shorter colons and less colonic infiltration [1].

Anti-inflammatory

Clinical studies using animal models have found that this peptide causes anti-inflammatory effects without the pigmentation generally associated with natural scar development. In addition, KPV contains anti-inflammatory and antimicrobial properties. It stops the growth of Candida albicans and Staphylococcus aureus and helps keep burns and other serious wounds from getting infected. The advantage of the peptide is in comparison to other anti-inflammatory medicines, which hinder the body’s capacity to fight infection [2].

Scarring

This peptide can reduce chronic inflammation, which is responsible for hypertrophic scarring (e.g., keloid). It is brought on by extensive macrophage infiltration, TNF immunoreactivity, and neutrophil abundance. Using alpha-MSH in this context results in improved wound healing and less severe scarring. These results suggest that this peptide could be used to prevent the scarring caused by some chemotherapeutic drugs. This method would not only lessen the bad side effects of cancer treatments but also make it easier to use higher quantities of these medications to get better results [3].

Summary

Although clinical research is continuing into the potential benefits and applications of KPV, healthcare professionals have found through research that it can reduce infection, fight inflammation in the intestines and may hold promise for those suffering with IBD. It has also demonstrated that it can accelerate wound healing and stop hypertrophic scars from forming without resulting in skin pigmentation with better cosmetic results.

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 18061177/

[2] https://pubmed.ncbi.nlm.nih.gov/ 10670585/

[3] https://pubmed.ncbi.nlm.nih.gov/ 25431356/

Buy KPV Peptide Vial 2mg

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