Sermorelin & Ipamorelin

Description

Sermorelin Ipamorelin Peptide Combo

Sermorelin Ipamorelin peptides work in synergy to promote muscle mass, weight-loss and healthy sleep patterns.  Research is ongoing into the plethora of benefits that these two peptides can offer, however when used together the benefits can be even greater.

What is Sermorelin?

Sermorelin is a GHRH analogue used to measure growth hormone secretion. It has been shown to strengthen bone density, reduce scarring, fight dementia, and minimise seizure activity [1].

Sermorelin is a 29 amino acid bioidentical synthetic hormone peptide that has been proven to promote weight loss, anti-ageing, and muscle growth in animal studies.

Growth Hormones (GH) are less abundant as we get older, so it’s harder to lose weight, look young, and keep muscle mass. A study on mice revealed that targeted therapies like Sermorelin therapy make rebalancing hormones and improving overall health much more manageable. [2]

In studies, the rodent body has a complex signalling pathway that helps control and manage cellular activity. Tests have shown that human growth hormone is one of the most powerful anti-ageing treatments. Research has shown that Sermorelin can promote fat loss and muscle gain, reduce wrinkles, and improve mouse concentration by optimising HGH levels.

What is Ipamorelin?

Ipamorelin has five amino acids in its structure and is known as a pentapeptide. It is a GH secretagogue and an agonist, meaning it may bind to specific cell receptors and cause a physiological reaction. The peptide’s mechanism of action allows it to boost pituitary gland-based growth secretion expression in animal test participants. Moreover, the peptide has been found to reduce the production of somatostatin. The peptide can also increase IGF-1, or Insulin-like Growth Factor 1. It is essential for the growth and repair of muscle and skeletal tissue. [3]

Ipamorelin is a peptide that binds to the ghrelin/growth hormone secretagogue receptor. A study found that it had no effect on ACTH, prolactin, FSH, LH, TSH, or cortisol secretion [3]. It is one of the most selective GH secretagogues known. Because of its great specificity, the peptide has been studied as a treatment as well as a model peptide for learning how selectivity in receptor binding is produced.

One of the most prevalent adverse corticosteroid effects is Ipamorelin, which has been shown to reduce inflammation in diseases ranging from cancer to autoimmune illness. Mitigating glucocorticoid side effects may allow higher doses and more prolonged use of these drugs, reducing morbidity and mortality. Several studies have indicated that the peptide can minimize or reverse glucocorticoid adverse effects. [4]

Specifications

Ipamorelin

Molecular Formula: C38H49N9O5

Molecular Weight: 711.9 g/mol

Sequence: H-Aib-Ala(Unk)-D-2Nal-D-Phe-Lys-NH2

Physical Appearance: White Lyophilised Solid

Form: Sterile Filtered White Lyophilized

Solubility: Water Soluble

Size: 2mg

Sermorelin

Molecular Formula: C149H246N44O42S

Molecular Weight: 3357.882 g/mol g·mol−1

Physical Appearance: White Lyophilised Solid

Form: Sterile Filtered White Lyophilized

Solubility: Water Soluble

Size: 2mg

Benefits for researchers:

Benefits of the Sermorelin Ipamorelin Combo:

• Enhanced Growth Hormone Secretion: The unique combination of Sermorelin and Ipamorelin offers a potent and synergistic effect on growth hormone release, leading to increased research opportunities in understanding growth regulation and related disorders.
• Improved Cellular Metabolism: By influencing growth hormone secretion, this combo can provide valuable insights into cellular metabolism, including energy utilization, protein synthesis, and lipid metabolism.
• Neuroprotective Effects: The Sermorelin Ipamorelin Combo has demonstrated neuroprotective properties, opening doors to investigate its potential in neurological research and the treatment of neurodegenerative diseases.
• Enhanced Recovery and Tissue Repair: Researchers can explore the Sermorelin Ipamorelin stack’s potential in accelerating wound healing, tissue regeneration, and recovery from injuries, unraveling the mechanisms behind these processes.
• Anti-Aging and Wellness Research: Investigating the Sermorelin Ipamorelin Combo’s effects on aging-related processes can uncover promising avenues for anti-aging interventions and overall well-being.

References:

1. https://www.sciencedirect.com/topics/neuroscience/sermorelin
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699646/
3. https://pubmed.ncbi.nlm.nih.gov/11735244/
4. https://pubmed.ncbi.nlm.nih.gov/11735244/

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