Tirzepatide Peptide Vial

Description

Tirzepatide Peptide Vial

Tirzepatide is a synthetic peptide composed of 39 amino acids that has shown promise in managing type 2 diabetes and obesity. It works by stimulating insulin release and reducing glucose production, leading to improved glycemic control.

This dual-action peptide acts as a receptor agonist for both glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), making it a unique and potentially effective treatment option for weight loss. Tirzepatide is administered through weekly subcutaneous injections, offering convenience and ease of use for patients. Further research is needed to fully understand its long-term side effects and potential cardiovascular benefits.

Specification

Molecular Formula: C225H348N48O68

Molecular Weight: 4813.527 g/mol

Physical Appearance: White Lyophilised Solid

Form: Sterile Filtered White Lyophilized

Solubility: Water Soluble

Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

Size: 2mg | 5mg

Research

Hunger reduction

Tirzepatide has been shown to effectively reduce hunger in individuals with type 2 diabetes and obesity. As a dual agonist for both GLP-1 and GIP receptors, Tirzepatide works by activating these receptors in the brain to suppress appetite which leads to increase satiety. This mechanism of action helps individuals feel fuller for longer periods, reducing their overall food intake.

According to clinical trials, Tirzepatide delays stomach emptying in the early stages of administration, but this effect progressively diminishes over time due to tachyphylaxis. As evidenced by the similarity between these effects and those observed with pure GLP-1R agonists, this action of tirzepatide is governed almost exclusively by its GLP-1 activity and not at all by its GIP activity.

By addressing both aspects of hunger regulation, Tirzepatide offers potential benefits in weight management and can assist individuals in making healthier food choices while achieving sustainable weight loss goals.

Weight Loss

Tirzepatide stimulates GIP receptors in adipose cells, resulting in an increase in insulin sensitivity. This, in turn, leads to a decrease in adipose inflammation and an increase in adiponectin levels, as well as the associated benefits.

GIP signalling in the central nervous system regulates hypothalamic feeding centres, resulting in decreased food intake and enhanced glucose handling, according to research. This results in a reduction in body weight. Thus, it appears that Tirzepatide influences weight through adiponectin signalling directly in adipose tissue and through CNS alterations that reduce appetite levels via GIPR signalling in the brain.

Cardiovascular Benefits

Tirzepatide has shown promising cardiovascular effects in various studies. Research suggests that it can lead to improvements in lipoprotein profiles, reducing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels while increasing high-density lipoprotein cholesterol (HDL-C) levels. These changes contribute to a more favorable lipid profile and may help reduce the risk of atherosclerotic cardiovascular disease.

Additionally, Tirzepatide has been associated with reductions in blood pressure and improvements in other cardiometabolic risk factors. These findings highlight the potential cardiovascular benefits of Tirzepatide, making it a promising therapeutic option for individuals with type 2 diabetes and obesity compared to other medications.

Summary

Tirzepatide has demonstrated several benefits in the management of type 2 diabetes and obesity. It has shown efficacy in achieving better glycemic control, reducing glycosylated hemoglobin levels, and improving fasting glucose levels.

Tirzepatide also cause significant weight loss by reducing appetite through the slowing down of gastric emptying and interacting with brain areas associated with GLP-1. Additionally, it has been found to improve cardiometabolic risk factors, including reductions in blood pressure, waist circumference, and fasting insulin levels.

Furthermore, Tirzepatide has shown potential benefits in maintaining weight loss and improving cardiovascular health. These findings highlight the therapeutic potential of Tirzepatide as a promising treatment option as weight loss medication.

References:

[1] https://www.nejm.org/doi/full/ 10.1056/NEJMoa2206038

[2] https://www.diabetesresearch clinicalpractice.com/article/ S0168-8227(23)00533-8/fulltext

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