VIP

Description

VIP (Vasoactive Intestinal Peptide) 2mg

A vasoactive intestinal polypeptide VIP, is a hormone in the intestine. Glucagon/secretin family member VIP is a 28-amino acid peptide ligand for class II G protein-coupled receptors.

What is VIP (Vasoactive Intestinal Peptide)?

Vasoactive Intestinal Peptide (VIP) has been shown to reduce inflammation throughout the body. Research has suggested it could be beneficial in treating inflammatory bowel disease, neurodegenerative disease, pulmonary fibrosis, and cardiac fibrosis. VIP  acts an anti-inflammatory, is a dominant immune system controller and furthermore to its antifibrotic effects, which appear to be negotiated by anti-inflammatory actions. It is attracting attention to preserve cognitive function in the context of neurodegenerative disease.

Specifications

Sequence: HSDAVFTDNYXRLRKQMAVKKYLNSXLN
Molecular Formula: C147H237N43043S

Size: 2mg

Research

Immune system

VIP can enhance the immune system. It inhibits pro-inflammatory cytokines and stimulates the production of anti-inflammatory cytokines, thereby reducing inflammation. This process is called immunological modulation. In addition, vasoactive intestinal peptide impacts the communication pathways between the immune system and the rest of the body beneficially, enhancing immunological health. [1]

Vasoactive intestinal peptide is suggested to aid inflammatory/autoimmune conditions, such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, Parkinson’s disease, septic shock, uveoretinitis, and experimental models of brain inflammation. However, research is limited, and further investigations are needed. [2]

Inflammation

VIP can help regulate joint inflammation and limit cartilage and bone deterioration in arthritis. This is because it works as a deactivation factor for macrophages. This means that it inhibits the synthesis of pro-inflammatory cytokines (IL-1, IL-6, and IL-12) and TNF-a (tumor necrosis factor-a) while promoting the production of anti-inflammatory cytokines, including IL-4, IL-10, IL-13, and IGF-1 (insulin-like growth factor 1). [3]

Heart

Because of its effect on smooth muscles, VIP is beneficial for lung and heart health. Research has shown that vasoactive intestinal peptide has a potent dilating effect that causes the smooth muscle in your blood vessels, respiratory system, digestive system, and other organs to relax and dilate. [4]

Vasoactive intestinal peptide can enhance blood circulation and expand airways. Therefore, it has the potential to be a successful treatment for illnesses such as chronic obstructive pulmonary disease (COPD), asthma, and pulmonary arterial hypertension (PAH). [5]

Gut health

Boosting digestive health, this peptide hormone has many potential applications. It encourages the epithelial cells lining your intestines to differentiate, increase, and adhere to one another, all of which contribute to maintaining a healthy intestinal wall. [6]

Vasoactive intestinal peptide is antibacterial against specific microorganisms and encourages the proliferation of healthy gut bacteria. In addition, it modulates stomach acid secretion and large intestine water and ion absorption. Furthermore, VIP promotes healthy peristalsis by blocking the contraction of smooth muscle and stimulating the release of mucus by Goblet cells. [7] [8]

Circadian rhythm

Based on animal research, it is suggested that VIP is responsible for coordinating the timing of SCN operation with the ambient light-dark cycle and may therefore have an impact on sleep.

Vasoactive Intestinal Peptide-deficient mice have weaker (i.e., lower amplitude) circadian rhythms and clocks that are out of sync with the SCN and other tissues [9].

In the adrenal glands, VIP-deficient mice lacked circadian rhythms (Per1), whereas, in the liver, the phase or timing of the circadian rhythm was significantly altered.

Summary

Based on existing studies, VIP appears to be effective in treating:

• Autoimmune conditions
• Inflammatory bowel diseases such as Ulcerative Colitis and Crohn’s
• Irritable bowel syndrome
• Arthritis: both rheumatoid and osteo
• High blood pressure
• COPD
• Cognitive decline
• Regulation of the circadian rhythm

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982157/
2. https://pubmed.ncbi.nlm.nih.gov/18383379/
3. https://pubmed.ncbi.nlm.nih.gov/11862320/
4. https://pubmed.ncbi.nlm.nih.gov/16247516/
5. https://pubmed.ncbi.nlm.nih.gov/11121793/
6. https://pubmed.ncbi.nlm.nih.gov/31559013/
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053281/
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002535/
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942163/

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