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FOXO4-DRI is a modified version of the natural FOXO4 protein. Clinical investigations have illustrated that FOXO4-DRI can eliminate senescent cells, reduce tissue aging and improve the function of the organs. FOXO4-DRI affects insulin signalling, cell cycle control, and oxidative stress signalling. In animal studies, FOXO4-DRI, a cell-penetrating peptide, has been shown to induce apoptosis and reverse ageing.
15ml contains 10mg FOX04-DRI Peptide
30ml contains 20mg FOX04-DRI Peptide
£200.71 – £396.42
FOXO4-D-Retro-Inverso is a modified form of the FOXO4 protein, which extends the protein’s half-life and permits it to disrupt normal FOXO4 function. Clinical investigations have shown fewer senescent cells, better organ function, and younger tissue “biological age” as a result of using this protein. FOXO4-DRI Nasal Spray can affect insulin, cell cycle, and oxidative stress signalling. Research has found that this cell-penetrating peptide has been found to reverse the effects of ageing in animals.
Foxo4dri is a senolytic peptide that disrupts the p53 gene, causing apoptosis in ageing cells. In the future this peptide may lead to a disease-free life with further investigation by reducing senescent cell formation.
What are senescent cells?
As we age, cells become senescent, meaning they can no longer divide or support their tissues. These cells generate damaging chemical signals that cause nearby cells to be senescent, which can cause tissue damage, increased inflammation, and increased cancer risk.
The FOXO4 peptide has been shown to inhibit the development of these harmful cells in animal subjects. Furthermore, it can even seek and eliminate these cells in test subjects’ bodies.
Molecular Formula: C228H388N86O64
Sequence: H-LTLRKEPASEIAQSIL EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH
Molecular Weight: 5358.05 g/mol
Size: 15ml | 30ml
The foxo4 peptide was tested on naturally ageing animals and mice which were genetically designed to age quickly. After subjecting the subjects to harsh chemotherapeutic treatments, scientists found some intriguing results. On both sets of rats, FOXO4-DRI Nasal Spray substantially mitigated chemotherapy-induced harm. The FOXO4 medication also restored liver and renal function and fur loss in the animal test subjects [1].
Neurodegenerative
The exact cause of age-related cognitive decline like Alzheimer’s isn’t fully understood, despite extensive research. A change in proteasome activity has been linked to neurodegenerative diseases. Disrupted proteasome activity has been linked to Parkinson’s, Early-onset dementia, Huntington’s, and Prion diseases. However, it is unclear whether this is a primary cause or a secondary contributor [2].
Also, ALS (Lou Gehrig’s disease) affects proteasome function. This scientific discovery that extracellular FOXO protein may help treat or prevent neurodegenerative disorders has prompted researchers to explore the idea that exogenous FOXO protein may be helpful. A modified FOXO protein, like FOXO4-DRI Nasal Spray, could potentially help slow the progression of neurodegenerative diseases, at the very least [3].
Heart disease
The older we get the chance of developing heart disease increases. A reduction in heart proteasome activity causes this risk. Proteasomes are in charge of getting rid of proteins that the cell has marked as “damaged” or not working right. Research in rats shows that age affects the activity of the proteasome, which leads to an increase in the damaged proteins in the heart [4].
FOXO proteins help with autophagy and the activity of the proteasome. Elevated FOXO4 levels lead to increased proteasome activity, causing less oxidation and protein damage in specific tissues. FOXO4-DRI Nasal Spray or a variant may help the heart’s natural maintenance functions, which could help slow down the effects of ageing on the heart’s ability to pump blood around the body [5].
Anti-ageing
Encumbered or senescent cells benefit from FOXO4, because it attaches to p53, it can stop the senescent cells from dying. DRI peptide blocks FOXO4-p53 interaction. P53 activates apoptotic proteins and causes cell death, which allows for more significant tissue regeneration by removing aging cells from tissues. The DRI peptide increased tissue regeneration and length of life in ageing mice in research studies.
This is the period during which the body is active. It dwindles with age. A person’s health span can be extended by reducing biological tissue ageing. The older mice live longer, and have less impairment such as cardiac disease and musculoskeletal trouble [6].
Whilst animal research is still in its early stages, scientists believe FOXO4-DRI nasal spray medication could be a potential cure for age-related disorders.
FOXO4-DRI Nasal Spray has been shown to increase apoptosis in senescent cells, improving tissue function and overall general wellbeing in animal models. Although the extent of FOXO4 DRI’s effects is unknown, but the protein may be able to shed light on age-related diseases like Alzheimer’s, cardiovascular diseases, and general cell senescence. In mice, FOXO4-DRI nasal spray has minimal side effects and high subcutaneous bioavailability. However, mice dosage does not translate to humans.
[1] https://pubmed.ncbi.nlm.nih.gov/ 28340339/
[2] https://pubmed.ncbi.nlm.nih.gov/ 14556719/
[3] https://pubmed.ncbi.nlm.nih.gov/ 29428128/
[4] https://www.sciencedirect.com/ science/article/abs/pii/ S0003986101926633 ?via%3Dihub
[5] https://www.hindawi.com/ journals/omcl/2017/3494289/
[6] https://www.cell.com/cell/ pdf/S0092-8674(17)30246-5.pdf
Pharma Lab Global is one of the best locations to purchase high purity FOXO4-DRI Nasal Spray for research use. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy FOX04-DRI Peptide Vial and buy FOX04-DRI Pre Mixed peptide. Buy FOXO4-DRI Peptide from Pharma Lab Global today!
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DISCLAIMER: All products sold by Pharma Lab Global are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.
| Size | 15ml, 30ml |
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TO PURCHASE PRODUCTS FROM OUR WEBSITE YOU MUST BE AT LEAST 21 YEARS OF AGE.
DISCLAIMER: All products sold by Pharma Lab Global are for in-vitro research and laboratory use only. These products are not designed for use or consumption by humans or animals. Nothing on this Website is intended to diagnose, heal, treat, cure, mitigate or prevent disease. By purchasing from our Website the buyer accepts and acknowledges the risks involved with consumption and handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. All products are to be handled by qualified and properly trained research or laboratory professionals only.
