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Humanin

£45.99£53.64

Studies have suggested that Humanin has protected cells from dying, causing diseases such as Alzheimer’s and Diabetes.

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Description

Humanin Peptide Vial 10mg Description

Humanin (HN) is a naturally occurring polypeptide that has been shown to decrease neuronal cell death produced by multiple Alzheimer’s disease genes, according to research. The Humanin peptide is encoded by mitochondrial DNA and works as a cytoprotective protein, preventing cells from dying due to apoptosis.

Apoptosis is the term used to describe cell death that has been predetermined. According to the results of the tests, it keeps the cells healthy by shielding them from this destructive process. It also protects neurons, heart tissue, muscle cells, and the eye’s retina, among other things.

Humanin Research findings

Under a clinical study, there are several advantages of using humanin peptide. Although research on the benefits of humanin is limited, there is enough evidence to support the following effects of this peptide.

Age
According to research, growth hormone (GH) harms HN peptide levels. In one study, researchers found that mice who were unable to create sufficient amounts of GH had greater levels of HN and lived longer lives than mice who were able to produce appropriate amounts of GH [1].

According to additional studies, animals belonging to centenarians have three times the quantity of humanin found in controls.

Moreover, high-dose nitric oxide (HN) has been shown to decrease cell death, improve insulin sensitivity, reduce inflammation, block cell death, and dissolve atherosclerotic plaques.

In light of the findings of recent studies, it is possible that taking a humanin supplement can extend one’s life [2].

Neuroprotection
Humanin appears to be protective against programmed cell death in specific settings, according to research in rats[iv]. According to the researchers, the peptide can protect neurons in the context of Alzheimer’s disease by reducing cell death induced by the buildup of beta-amyloid plaque. The antioxidant humanin has also been shown to protect against excitotoxic cell death in high-intensity NMDA pulses studies [3].

With further robust research, scientists believe that humanin function in treating neurodegenerative diseases such as Alzheimer’s disease and other forms of dementia could be a viable treatment option in the near future.

In clinical investigations, it was discovered that humanin protects neurons in two distinct ways. As a result of these two methods, mitochondria are prevented from triggering the death pathway. tBid and Bid are Bcl-2 boosting proteins, and humanin inhibits their action, preventing them from activating the apoptotic signalling pathway.

Researchers in Argentina have discovered that the neuroprotective protein humanin is secreted by astrocytes to protect synapses in hippocampus neurons. Humanin supplementation has been demonstrated to be quite valuable for older animals in reducing age-related impairments such as memory loss [4].

Diabetes
Research has shown that HN can also decrease pancreatic beta-cell death and improve glucose metabolism in non-diabetic animal subjects and these other effects. This suggests that humanin may be effective in treating both type 1 and type 2 diabetes.

Humanin also operates on the hypothalamus, boosting sensitivity to insulin in the liver and helping to maintain a healthy blood glucose level, according to laboratory studies.

As a result, recent investigations have demonstrated that humanin can cure obesity by limiting weight gain via increasing glucose-stimulated insulin release [5].

Heart disease
According to the research, the humanin peptide helps safeguard blood vessels from the consequences of bad cholesterol, also known as oxidized LDL cholesterol, by reducing inflammation. As a result of LDL oxidation, it also interacts with the production of free radicals, which reduces the amount of species in the blood by half. The fact that it lowers the rate of cell death by half is noteworthy.

The fact that humanin levels fall with age makes it imperative that they remain constant to maintain your health. In addition, according to new research, the peptide humanin can be used as a diagnostic marker as well as a therapy for cardiovascular disorders.

Humanin can also help prevent damage caused by left coronary occlusion by increasing the activity of AMPK and eNOS in the body, hence lowering oxidative stress levels in the bloodstream [6].

Bone Health
Researchers have discovered that humanin may benefit bones in two ways. The first is to stop the death of chondrocytes, the cells that maintain bones robust. Humanin promotes chondrocyte growth while inhibiting osteoclast formation. Osteoclasts are the cells that degrade and remodel bone. It causes substantial bone loss when overactive. Humanin supplements can decrease significant bone formation and loss by inhibiting this development [7].

Eyes
The RPE is protected by humanin, according to a study (AMD). This is one of the most important human health benefits available from a clinical perspective.

The RPE nourishes the vision-producing cells in the retina. It also absorbs light, filters blood components, and maintains the inner eye’s health.

Humanin protects AMD by increasing mitochondrial levels and protecting against oxidative stress and RPE cell death.

RPE function is said to be improved by supplementing with humanin. However, further studies on mice are needed for retinal illnesses like AMD [8].

Humanin Peptide summary

Humanin exerts neuroprotective and cytoprotective actions by binding to intracellular or extracellular receptors. In addition, Humanin has been demonstrated to prevent cellular death, promote longevity, and reduce insulin resistance.

Although Humanin has shown promising outcomes in research, clinical studies are still pending due to the peptide’s recent discovery (15-20 years ago). Therefore, clinical trials are underway to completely characterize this peptide’s profile and determine its potential as a treatment agent for common neuro diseases.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255622/
  2. https://gero.usc.edu/2020/06/24/protein-in-mitochondria-may-regulate-health-and-longevity/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256269/
  4. https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.02-0018fje
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705736/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774506/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717796/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263384/
Buy Humanin Peptide vial 10mg

Pharma Lab Global is one of the best locations to purchase high purity Humanin for research. Pharma Lab Global is a trusted supplier of peptides and sarms worldwide. You have the option to buy Humanin Pre Mixed peptide from here. Buy Humanin from Pharma Lab Global today!

Humanin Specifications

Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Molecular Formula: C121H205F3N34O34S2
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble
Purity: >99.8%
Storage: -20 °C.

Disclaimer: All products listed on this website and provided through Pharma Labs Global are intended for medical research purposes only. Pharma Lab Global does not encourage or promote the use of any of these products in a personal capacity (i.e. human consumption), nor are the products intended to be used as a drug, stimulant or for use in any food products.

Additional information

Size

10mg Vial, Kit = 10mg vial, bac water, syringes

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