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Humanin Peptide Vial 10mg

Humanin (HN) is a naturally occurring polypeptide that has been shown to decrease neuronal cell death produced by multiple Alzheimer’s disease genes, according to research. The HN peptide is encoded by mitochondrial DNA and works as a cytoprotective protein, preventing cells from dying due to apoptosis.

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Description

Humanin Peptide Vial 10mg

Humanin (HN) is a naturally occurring polypeptide that has been shown to decrease neuronal cell death produced by multiple Alzheimer’s disease genes, according to research. The Humanin peptide is encoded by mitochondrial DNA and works as a cytoprotective protein, preventing cells from dying due to apoptosis.

Apoptosis is the term used to describe cell death that has been predetermined. According to the results of the tests, it keeps the cells healthy by shielding them from this destructive process. It also protects neurons, heart tissue, skeletal muscle cells, and the eye’s retina, among other things including being of benefit to those suffering with Alzheimer’s disease.


Specifications

Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Molecular Formula: C121H205F3N34O34S2
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble
Purity: >99.8%
Storage: -20 °C.

Size: 10mg


Humanin Research

Under a clinical study, there are several advantages of using humanin peptide. Although research on the benefits of this peptide is limited, there is enough evidence to support the following effects of this peptide.

Age

According to research, growth hormone (GH) harms humanin peptide levels. In one study, researchers found that mice who were unable to create sufficient amounts of GH had greater levels of humanin and lived longer lives than mice who were able to produce appropriate amounts of GH [1].

According to additional studies, animals belonging to centenarians have three times the quantity of humanin found in controls.

Moreover, high-dose nitric oxide (HN) has been shown to decrease cell death, improve insulin sensitivity, reduce inflammation, block cell death, and dissolve atherosclerotic plaques.

In light of the findings of recent studies, it is possible that taking a HN supplement can extend one’s life [2].

Neuroprotection and Alzheimer’s Disease

Humanin appears have a neuroprotective factor against programmed cell death in specific settings, according to research in rats. According to the researchers, the peptide can protect neurons in the context of Alzheimer’s disease by reducing cell death induced by the buildup of beta-amyloid plaque. The antioxidant humanin has also been shown to protect against excitotoxic cell death in high-intensity NMDA pulses studies [3].

With further robust research, scientists believe that humanin function in treating neurodegenerative diseases such as Alzheimer’s disease and other forms of dementia could be a viable treatment option in the near future.

In clinical investigations, it was discovered that humanin interacts to protect neurons in two distinct ways. As a result of these two methods, mitochondria are prevented from triggering the death pathway. tBid and Bid are Bcl-2 boosting proteins, and humanin inhibits their action, preventing them from activating the apoptotic signalling pathway.

Researchers in Argentina have discovered that the neuroprotective protein humanin is secreted by astrocytes to protect synapses in hippocampus neurons. Humanin supplementation has been demonstrated to be quite valuable for older animals in reducing age-related impairments such as memory loss [4].

Diabetes

Research has shown that HN can also decrease pancreatic beta-cell death and improve glucose metabolism in non-diabetic animal subjects and these other effects. This suggests that humanin may be effective in treating both type 1 and type 2 diabetes.

Humanin also operates on the hypothalamus, boosting sensitivity to insulin in the liver and helping to maintain a healthy blood glucose level, according to laboratory studies.

As a result, recent investigations have demonstrated that humanin can cure obesity by limiting weight gain via increasing glucose-stimulated insulin release [5].

Heart disease

According to the research, the HN peptide helps safeguard blood vessels from the consequences of bad cholesterol, also known as oxidized LDL cholesterol, by reducing inflammation. As a result of LDL oxidation, it also interacts with the production of free radicals, which reduces the amount of species in the blood by half. The fact that it lowers the rate of cell death by half is noteworthy.

The fact that HN levels fall with age makes it imperative that they remain constant to maintain your health. In addition, according to new research, this peptide can be used as a diagnostic marker as well as a therapy for cardiovascular disease.

This peptide can also help prevent damage caused by left coronary occlusion by increasing the activity of AMPK and eNOS in the body, hence lowering oxidative stress levels in the bloodstream [6].

Bone Health

Researchers have discovered that humanin may benefit bones in two ways. The first is to stop the death of chondrocytes, the cells that maintain bones robust. Humanin promotes chondrocyte growth while inhibiting osteoclast formation. Osteoclasts are the cells that degrade and remodel bone. It causes substantial bone loss when overactive. Humanin supplements can decrease significant bone formation and loss by inhibiting this development [7].

Eyes

The RPE is protected by humanin, according to a study (AMD). This is one of the most important human health benefits available from a clinical perspective.

The RPE nourishes the vision-producing cells in the retina. It also absorbs light, filters blood components, and maintains the inner eye’s health.

Humanin protects AMD by increasing mitochondrial levels and protecting against oxidative stress and RPE cell death.

RPE function is said to be improved by supplementing with humanin. However, further studies on mice are needed for retinal illnesses like AMD [8].

Summary

Humanin exerts neuroprotective and cytoprotective actions by binding to intracellular or extracellular receptors. In addition, this peptide has been demonstrated to prevent cellular death, promote longevity, and reduce insulin resistance. Furthermore, it has the potential to be beneficial to those living with Alzheimer’s disease however currently the peptide is only licensed for research use.

Although this peptide has shown promising outcomes in research, clinical studies are still pending due to the peptide’s recent discovery (15-20 years ago). Therefore, clinical trials are underway to completely characterize this peptide’s profile and determine its potential as a treatment agent for common neuro diseases.

References

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4255622/

[2] https://gero.usc.edu/2020/06/24/ protein-in-mitochondria-may-regulate-health-and-longevity/

[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6256269/

[4] https://faseb.onlinelibrary.wiley. com/doi/10.1096/fj.02-0018fje

[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3705736/

[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3774506/

[7] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6717796/

[8] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7263384/

Buy Humanin Peptide vial 10mg

Pharma Lab Global is one of the best locations to purchase high purity Humanin for research use. Pharma Lab Global is a trusted supplier of peptides worldwide. You have the option to buy Humanin Pre Mixed peptide and Humanin Nasal Spray from here. Buy Humanin Peptide from Pharma Lab Global today!


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Additional information

Size

10mg Vial, Kit = 10mg vial, bac water, syringes

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