Tesofensine Capsules

Description

Tesofensine Capsules 500mcg

Tesofensine was initially studied for the treatment of Alzheimer’s disease and Parkinson’s disease. Subsequently, it was withdrawn from development for these uses because early trial findings demonstrated a lack of efficacy against these disorders.

Nonetheless, the original studies regularly documented weight reduction as a side effect, particularly in individuals who were overweight or obese. Hence, it was decided to continue developing Tesofensine as a treatment for obesity.

Tesofensine is primarily an appetite suppressant, although it may also increase energy expenditure at rest. A successful clinical trial for the treatment of obesity have concluded that it can cause a significant reduction in body weight.

Specifications:

Formula: C17H23Cl2NO
Molecular weight: 328.28 g·mol−1

Size: 60 Capsules | 500mcg per capsule.

Tesofensine Research

Weight Loss

According to clinical trials, Tesofensine capsules are at least twice as efficient as any present prescription for weight loss. In addition, they are reported to have a substantially smaller number of side effects. The research being conducted, with an aim to bring Tesofensine to market as an weight loss supplement for obese patients, is investigating how this peptide regulates hunger and satiety to cause weight loss [1].

According to a study conducted on animal subjects, results indicated that Tesofensine had beneficial effects glycemic control in a dose-dependent manner. In addition, Tesofensine has been shown to significantly decrease the insulin response in fundamental glucose tolerance tests. This suggests that there is a reduction in the amount of insulin released in response to a sugar load [2].

Insulin resistance, the development of diabetes, cardiovascular disease, and even neurodegenerative illnesses have all been related to chronic inflammation. Tesofensine helps to shift the equilibrium of the metabolism and provides the body with a fighting chance against obesity by interrupting the cycle of fat deposition and inflammation that leads to both of these conditions.

Neurodegenerative Conditions

Tesofensine is known to raise levels of the neurotrophic factor BDNF and to stimulate neurogenesis in the hippocampus, both of which are indications that it exhibits antidepressant properties. However, this has not been the primary focus of the research that has been conducted, as the compound was originally developed for its dopaminergic qualities, and it was only later that its anti-obesity capabilities were discovered. Tesofensine offers a one-of-a-kind option to applications in the fields of anti-obesity and antidepressant medication since its properties transcend both of these categories [3].

Summary:

Phase ii clinical trials have found subjects treated with tesofensine experienced significant weight loss and enhance energy levels allowing them to increase their physical activity, with few known adverse effects. In addition to causing a reduction of body fat, research also found that it had a positive significant effect on the regulation of glucose levels in test individuals.

Tesofensine has also been demonstrated to display antidepressant characteristics, it could be useful in the management of pain, and has the potential to improve cognition and memory. Further studies could establish whether this peptide could have a significant effect alzheimer’s and parkinson’s disease research in the future.

References:

[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3055463/

[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7801751

[3] https://www.sciencedirect.com/ topics/pharmacology-toxicology-and-pharmaceutical-science/tesofensine

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