Ipamorelin Nasal Spray
Ipamorelin a pentapeptide and has five amino acids in its structure. It is a growth hormone secretagogue and an agonist, meaning it may have the ability to bind to specific cell receptors and cause a physiological reaction. The peptide’s mechanism of action allows it to boost pituitary gland-based growth secretion expression in animal test participants. Moreover, this peptide has been found to reduce the production of somatostatin. Ipamorelin can also increase IGF-1, or Insulin-like Growth Factor 1, and is essential for the growth and repair of muscle and skeletal tissue.
Ipamorelin is a peptide that binds to the ghrelin/growth hormone secretagogue receptor. A study found that it had no effect on ACTH, follicle stimulating hormone, thyroid stimulating hormone, prolactin, luteinising hormone, or cortisol secretion . It is one of the most selective GH secretagogues known.
Molecular Formula: C38H49N9O5
Molecular Weight: 711.9 g/mol
Size: 15ml | 30ml
One of the most prevalent adverse corticosteroid effects is Ipamorelin, which has been shown to reduce inflammation in diseases ranging from cancer to autoimmune illness. Mitigating glucocorticoid side effects may allow higher doses and more prolonged use of these drugs, reducing morbidity and mortality. Several studies have indicated that ipamorelin nasal spray can minimize or reverse glucocorticoid adverse effects.
Long-term glucocorticoid use causes bone loss and an increased risk of fracture. Bisphosphonates, hormones, and novel monoclonal antibodies are current treatments. These treatments work, but they have adverse effects, are ineffective, or are expensive. However, ipamorelin nasal spray is relatively inexpensive and has few known adverse effects. In rodent studies, ipamorelin nasal spray reversed corticosteroid-induced bone loss and increases bone growth fourfold .
Furthermore, research demonstrated that ipamorelin peptide can enhance bone mineral density and the strength of existing and freshly created bone. Also, ipamorelin can counteract some of the side effects of steroid use, like muscle loss and higher visceral fat deposition .
GH and growth hormone secretagogues like ipamorelin have been shown to attenuate the muscle catabolic effects of glucocorticoids. Ipamorelin reduces liver nitrogen wasting and improves nitrogen balance in glucocorticoid-treated rats. Muscle wasting is a common treatment-limiting adverse effect of glucocorticoids. For patients on glucocorticoids, the potential to reverse muscle catabolism and bone loss with a single medication could be enormously advantageous .
Inhibition of ghrelin receptor signalling by Ipamorelin
The ghrelin receptor is known to be overexpressed in cancer (e.g. human carcinomas) and heart failure patients. Scientists have proposed using ipamorelin as a PET probe to diagnose cancer. A PET probe made of ipamorelin, which is easily synthesized in the lab, has been shown to be feasible in primary in vitro experiments. This will be followed by in vivo testing and criteria for interpreting PET tests performed with the probe .
Clinical studies have found that Ipamorelin nasal spray can increase insulin release in diabetic rats. This impact is probably due to indirect calcium channel stimulation in pancreatic islet cells that make and store insulin. The effects of ipamorelin on the pancreas may help us comprehend the constraints of type 2 diabetes and develop new therapies or even prevention approaches .
Post-operative ileus (POI) is a common complication of surgery, particularly abdominal surgery. The Gl system malfunctions, preventing individuals from taking oral nutrients. Although it causes discomfort, POI slows hospital discharge and overall recovery. Clinical trials are continuing to establish if ipamorelin nasal spray can lessen POI.
In summary, Ipamorelin is a synthetic peptide that acts as a growth hormone releasing peptide (GHRP), stimulating the pituitary gland to increase the production of growth hormone in the body. This can lead to an enhanced rate of muscle growth and recovery, making it popular among athletes and bodybuilders. It also promotes fat loss, improves sleep quality and supports anti-aging benefits due to its effect on cell regeneration and repair. Unlike other GHRPs, Ipamorelin does not cause an increase in hunger or impact cortisol and prolactin levels significantly, which makes it a safer option for long-term use. It’s usually administered via subcutaneous injection and dosages depend on the individual’s goals and physiological condition.
 https://pubmed.ncbi.nlm.nih.gov/ 9849822/
 https://pubmed.ncbi.nlm.nih.gov/ 11735244/
 https://pubmed.ncbi.nlm.nih.gov/ 10828840/
 https://pubmed.ncbi.nlm.nih.gov/ 30282322/
 https://pubmed.ncbi.nlm.nih.gov/ 15665799/
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