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Mots-c Peptide Vial 10mg

MOTS-C peptide, also known as “mitochondrial-derived peptide,” is a promising molecule that has gained attention in the field of longevity and metabolic health. It has been found to play a crucial role in regulating metabolism, energy expenditure, and insulin sensitivity. Research suggests that MOTS-C peptide has the potential to improve mitochondrial function, enhance glucose utilization, and even protect against age-related diseases.



SKU PLG: Mots-C vial Categories ,


Mots-c Peptide Vial 10mg

MOTS-c is a mitochondrial-derived peptide that has been found to maintain metabolic balance, reduce obesity, and prevent diabetes in animal studies. This short peptide is part of a broader set of MDPs that experts claim is important in mitochondrial signalling and energy management.

Numerous MDPs are active in the nucleus, new research shows. Moreover, many of them penetrate the bloodstream, causing systemic effects, as revealed in animal testing.

Mots-C peptide’s primary function is to stimulate growth hormone release by blocking the enzyme that converts insulin and glucose to glycogen. The enzyme breaks down glycogen stored in the liver and pancreas. As a result, the body can turn fat into energy more efficiently when this enzyme’s activity increases.

This suggests that Mots-C Peptide speeds up fat metabolism. In addition, because increasing glucose levels assist the body in losing fat and maintaining muscle mass, they also help the body burn fat faster.

In animal studies, the MOTS-c peptide is a newly found MDP linked to metabolism, lifespan, exercise capacity, weight management, and illnesses like osteoporosis and diabetes.


Molecular Formula: C101H152N28O22S2

Molecular Weight: 2174.64 f/mol

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble

Storage: Peptides should be refrigerated at 4˚C or below for a period of up to 3 months. To prolong the life span of the peptides they may be placed in a freezer for up to 12 months. Once reconstituted peptides should be refrigerated/stored at 4˚C for up to 30 days.

Size: 10mg

MOTS-C Research

Diabetes and insulin resistance

According to new research from the University of South California, MOTS-C prevented the immune system from damaging insulin-producing pancreatic cells. Thus, it prevented type 1 diabetes in mice in the lab.

Diabetes type 1 is a common illness that attacks the immune system’s insulin-producing cells in the pancreas. The peptide MOTS-c assists regulatory T-cells, helping to minimize killer T-cell activation in animal tests [1].

The MOTS c is known to target skeletal muscle. Because it is an AMPK activator, which improves insulin sensitivity and glucose absorption in muscle cells without increasing insulin in the test animals’ bodies [2].

Besides the USC research, several other studies on mice show the importance of MOTSc in the pathophysiology of insulin sensitivity. The peptide may provide therapeutic potential for scientists monitor pre-diabetic lean mice. They further hypothesize that MOTS-c changes could indicate insulin sensitivity. While the findings in animal models are encouraging, more clinical trials are required to understand the impacts fully and approve for human use.

Weight loss

Researchers at the Leonard Davis School of Gerontology (USC) revealed MOTS c hormone’s efficiency in preventing weight gain from a high-fat Western diet, due to it’s fatty acid oxidation process [3]. Although research was in its infancy scientists were ecstatic to discover it could target muscle tissue and reverse, diet induced obesity and diet-induced insulin resistance in animals.

The team gave MOTS-c peptide injections to obese mice fed a high-fat diet to understand the impacts further. In the MOTS-c study, the injection reduced both effects in mice. The study also found that mots c regulates sphingolipid, monoacylglycerol, and dicarboxylate metabolism. In addition, Mots c prevented fat formation and weight loss in test animals by downregulating these pathways [4].

The relationship between MOTS-C and fat loss has acquired scientific traction by qualified professionals in the medical field. According to another study, a lack of fat oxidation in mitochondria may increase circulating fat, prompting the animal body to increase insulin levels to eliminate fats from the bloodstream.


MOTS-c appears to promote longevity in animal studies. The study found a notable change in the peptide linked to an increased life span in animal species.

When the MOTS-c gene is altered, it causes the lysine protein to lose a glutamate residue at position 14. Scientists don’t know yet how this alteration affects the protein’s function in animals. However, they are confident because glutamate has distinct characteristics from lysine. Of course, further research is needed to grasp the implications correctly.

The mitochondria are an essential metabolic organelle linked to many age-related illnesses. Mots-c peptides may help extend animal test subjects’ lifespan and improve their general health [5].


Reduced MOTS-c levels in the circulation have been linked to increased endothelial cell dysfunction in animal research subjects undergoing coronary angiography.

Endothelial cells regulate plaque formation, blood pressure, and clotting. MOTS c stimulates endothelial cells, improving mice’s endothelium and blood vessel efficiency [6].

MOTS-C isn’t the only mitochondrial-derived peptide that can improve heart health. At least three MDPs appear to protect heart cells from inflammation and stress.

Thus, MDP dysregulation may play a critical role in initiating cardiovascular disease [7].


The mots-c peptide stimulates osteoblasts in the bone of test animals, resulting in the creation of type I collagen. It did so by regulating the TFG-beta SMAD pathways, which help osteoblasts thrive and survive. So, MOTS-C peptide promotes osteoblast survival and thus increases overall bone strength, this suggests that mots c improves osteoporosis.

The peptide increases the development of bone marrow stem cells via the same route as osteoporosis. This boosted osteogenesis (bone production) as a result. The research concluded that MOTS-c protects osteoblasts, enhances their health and longevity, and stimulates their production from stem cells.

Increasing research could lead to over-the-counter MOTS c medicine as beneficial prevention and treatment for osteoporosis [8].


MOTS-C peptide, also known as mitochondrial-derived peptide, offers several benefits for metabolic health and longevity. It can promote fatty acid metabolism in the liver and enhances metabolic flexibility and homeostasis. By regulating mitochondrial energy, it helps protect against age-related metabolic disorders, insulin resistance, and cardiovascular impairment.

Clinical studies have found that MOTS-C peptide nasal spray may also improve physical function, insulin sensitivity, and age-related metabolic diseases, including obesity. Additionally, MOTS-C peptide aids in glucose uptake regulation, lipid metabolism control, and enhanced insulin sensitivity. With its potential to increase energy expenditure, enhance fat burning, and suppress appetite, MOTS-C peptide shows promise as a valuable tool for overall health and well-being


[1] https://pubmed.ncbi.nlm.nih.gov/ 30725119/

[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC6185997/

[3] https://gero.usc.edu/2021/08/12/ mots-c-mitochondria-type-1-diabetes/

[4] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC6640593/

[5] https://www.sciencedirect.com/ science/article/abs/pii/S089158491 6302507?via%3Dihub

[6] https://pubmed.ncbi.nlm.nih.gov/ 29242099/

[7] https://pubmed.ncbi.nlm.nih.gov/ 31185388/

[8] https://pubmed.ncbi.nlm.nih.gov/ 31081069/

Buy Mots-C Peptide Vial 10mg

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Additional information

Weight 0.01 kg
Dimensions 1 × 1 × 1 cm

10mg Vial, Kit = 10mg vial, bac water, syringes