Tesamorelin Nasal Spray
Tesamorelin is a lipophilic peptide that has been clinically tested to be effective in removing fat from the abdominal area. It was initially used in the treatment of lipodystrophy in patients with HIV. It is also being studied for its ability to reduce body fat in those with obesity.
Lipodystrophy is the medical term used for increased body fat found in specific areas of the abdomen, hips, and pelvis. When lipodystrophy is present in a person, the skin around the body tends to become loose and saggy, causing a waxy, bumpy appearance to occur around the body. The most common areas affected by lipodystrophy are the thighs, hips, and abdomen.
Lipodystrophy can cause a wide variety of symptoms ranging from fatigue, anxiety, irritability, weight gain, and chronic pain.
For those suffering from excessive abdominal fat, lipodystrophy can cause serious health complications and health problems.
Tesamorelin Nasal Spray Research findings
Tesamorelin nasal spray works by stimulating the pituitary gland to release GHRH, which increases lipolysis. Lipolysis is the breakdown of triglycerides and lipids to produce fat loss.
Lipids and triglycerides are fats found in the body stored for energy. High levels of either can increase your risk of ailments, including heart disease.
Tesamorelin works by reducing visceral fat. In trials, mice given tesamorelin for weight loss lost 15% of their weight in 26 weeks .
Another 2014 study found tesamorelin reduced liver fat by 18%. The test mice got tesamorelin injected under their naval once a day.
Tesamorelin nasal spray is primarily used to treat HIV-associated lipodystrophy, which occurs due to both HIV infection and antiretroviral therapy. Lipodystrophy causes excessive fat accumulation in the abdomen and elsewhere. The physiologic mechanism is unknown, however, it is suspected that protease inhibitors play a substantial role in lipodystrophy aetiology .
Lipodystrophies patients were initially treated with diet, exercise, and some unsuccessful medicines. If those failed, surgery was a last resort, typically futile and complicated. The FDA authorized tesamorelin for HIV-associated lipodystrophy in 2010. The medication reduces adiposity by about 20% in this population .
Tesamorelin appears to be four times more effective than all other known medications combined in lowering adiposity .
HIV and GH deficiency
Recent research links HAART to endocrine and metabolic issues, including GH insufficiency. Because HIV alters the pituitary gland, roughly one-third of people on HAART suffer GH deficiency . This may answer how lipodystrophy is so widespread in HIV patients and why tesamorelin is so effective as a therapy. Tesamorelin is a safe and effective alternative to exogenous GH, especially for HIV-positive people.
HIV-positive people are more prone to cardiovascular disease due to excessive fat deposition and partly to antiretroviral medications activities. After highly active antiretroviral therapy (HAART), CVD prevention is regarded as the most significant medical intervention for long-term well-being in HIV-positive people. Statins were the foundation of medical care until recently.
Tesamorelin nasal spray decreases triglycerides, total cholesterol, and non-HDL-C in HIV-positive patients and lowers lipodystrophy. In addition, Tesamorelin reduces visceral adipose tissue by 15% and triglyceride levels by 50 mg .
Notably, ectopic fat accumulation in lipodystrophy is linked to inflammation. Inflammation is a CVD risk factor. Visceral, hepatic, and epicardial fat are all related to a higher risk of CVD. Tesamorelin reduces inflammation and reduces CVD risk by lowering ectopic fat deposition.
Injury, diabetes, or even surgery can cause peripheral nerve damage; however, little can be done to rectify the condition because nerve cells are notoriously difficult to regenerate. However, research suggests that growth hormone manipulation therapy may improve peripheral nerve damage repair and speed . Tesamorelin nasal spray is now the frontrunner for such an intervention, partly due to FDA approval.
There is currently evidence that GHRH analogues, including tesamorelin, can improve cognition in patients with early dementia . For example, one study found that using tesamorelin or other GHRH analogues for 20 weeks increased GABA levels in the brain while lowering MI levels. In search of a cure or a prophylactic, these discoveries provide new areas for scientists to study.
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Tesamorelin Nasal Spray Specifications
Molecular Formula: C221H366N72O67S
Molecular Weight: 5136 g/mol
Physical Appearance: White Lyophilised Solid
Form: Sterile Filtered White Lyophilized
Solubility: Water Soluble
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