Elamipretide SS-31 Pre-Mixed Pen 25mg

Description

Elamipretide SS-31 Pre-Mixed Pen 25mg

SS-31 Elamipretide is a peptide that targets mitochondria and has showed promise in treating a variety of age-related functional impairments. Clinical trials have shown that it reduces age-related cardiac failure while improving mitochondrial dysfunction, synaptic damage, and cognitive impairment caused by lipopolysaccharide.

Furthermore, studies indicate that Elamipretide may ameliorate cognitive impairment and inflammatory reactions in the hippocampus. While more research is needed to fully understand its processes and possible therapeutic applications, these findings point to SS-31 Elamipretide’s potential health advantages in treating age-related diseases.

The SS-31 has several advantages, including the capacity to target and accumulate on the inner membrane of mitochondria, protect against mitochondrial depolarization, and be a tiny water-soluble peptide. Elamipretide SS-31 has the ability to enter the mitochondria and have an impact on mitochondrial function.

Specifications

Sequence: d-Arg-Dmt-Lys-Phe-NH2
Molecular Formula: C32H49N9O5
Molecular Weight: 639.8 g/mol

Size: 1 Single mixed cartridge | 2 Pre mixed cartridges | 3 Pre mixed cartridges | Pen kit with 1 pre mixed cartridge

Research

Physical endurance

Mitochondrial activity directly affects a neuron’s survival and function [1]. During apoptosis, mitochondria facilitate energy transfer from intracellular to extracellular compartments [2]. The mitochondria power human physical activity and endurance. That is, human survival is dependent on mitochondrial energy production. As a result, people with mitochondrial malfunction may experience significant weariness and require medication to restore mitochondrial activity.

An 8-week study indicated that elamipretide was effective in aged mice. Elamipretide SS-31 Peptide Vial 50mg promotes skeletal muscle function and exercise tolerance by restoring cellular redox equilibrium. However, a shift in redox homeostasis in aged muscles is also connected to energy deficits and exercise intolerance [3].

Recognising elamipretide’s potential for physical endurance, researchers are evaluating it for the treatment of Barth Syndrome, which is characterised by skeletal muscular weakness and physical disability. Daily elamipretide injections for 12 weeks effectively alleviated Barth Syndrome and related cardiac issues [4].

Aside from treating disorders such as Barth Syndrome, elamipretide can help the elderly keep their independence and quality of life by reducing the ageing process. Furthermore, Elamipretide’s effects on physical endurance are expected to transition from animal studies to human use.

Cognitive effects

The brain’s general health depends on the appropriate functioning of its blood supply. However, mitochondrial oxidative stress causes cognitive deterioration as we age. As a result, researchers conducted a trial to determine whether treating mitochondrial oxidative stress with the medication elamipretide improves cognition.

A 2-week trial on aged mice found that elamipretide significantly increased cerebral blood vessel dilation, leading to better working memory and motor skill development [5]. According to the findings, elamipretide could be utilised to prevent or treat cognitive loss caused by aging.

Prevention of cardiovascular disease

Elamipretide SS-31 pre-mixed pen can lower the risk of cardiovascular disease, namely diastolic dysfunction, an age-related heart condition. Diastolic dysfunction is caused by the hardening of the heart ventricles.

Elamipretide effectively corrected diastolic dysfunction in elderly mice by controlling proton leak and decreasing mitochondrial reactive oxygen species in cardiac muscle cells [6]. The study found that treating mitochondrial dysfunction could reverse age-related cardiac issues.

Elamipretide has good potential, however it is still being investigated. If the effects of this peptide remain consistent in human studies, it could be a viable treatment option for a variety of health concerns.

Mitochondrial dysfunction

Mitochondrial malfunction reduces cellular energy production, resulting in mitochondrial degeneration and a variety of other illnesses. Elamipretide’s ability to regenerate the inner mitochondrial membrane can treat mitochondrial malfunction, leading to beneficial outcomes [7].

Elamipretide stabilises the inner mitochondrial membrane, which prevents mitochondrial degeneration and improves mitochondrial function. Elamipretide can increase cellular energy production since mitochondria are crucial to the human body and responsible for cellular energy production.

Elamipretide ss-31 pre-mixed pen has increased physical endurance in patients with disorders associated with exercise intolerance by increasing energy production, as scientists have recognised this positive chain of events.

Summary

Research suggests that SS-31 Elamipretide, the mitochondria-targeted peptide can improve skeletal muscle function and increase exercise capacity by restoring redox homeostasis in cells. Elamipretide has also shown potential in addressing age-related cognitive impairment by promoting mitochondrial and synaptic health while reducing oxidative stress and neuroinflammatory responses.

Additionally, this peptide has been found to enhance functional connectivity in the hippocampus and protect mitochondria in conditions such as metabolic syndrome. These findings highlight the potential of SS-31 Elamipretide in addressing various age-related issues and improving overall mitochondrial function. However, further research is needed to fully understand its efficacy and safety.

References

[1] https://pubmed.ncbi.nlm.nih.gov/ 29391029/

[2] https://pubmed.ncbi.nlm.nih.gov/ 21321998/

[3] https://pubmed.ncbi.nlm.nih.gov/ 26820564/

[4] https://www.nature.com/articles/ s41436-020-01006-8

[5] https://onlinelibrary.wiley.com/ doi/full/10.1111/acel.12731

[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7377906/

[7] https://jneuroinflammation.bio medcentral.com/articles/10.1186/ s12974-019-1627-9

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