Kisspeptin Nasal Spray

Description

Kisspeptin Nasal Spray

The multifunctional peptide system known as kisspeptin is important to human reproductive physiology and may be used to treat infertility. It is produced by the KISS1 gene and comes in three different forms: KP-54, KP-13, and KP-10. These cleavage peptides, which were extracted from the human placenta, are known to increase the release of gonadotropin, a hormone that is crucial for controlling the generation of reproductive hormones.

Kisspeptin peptides may play a role in controlling emotional and sexual conduct, according to research. They promote gonadotropin-releasing hormone (GnRH) secretion by acting as ligands for the GPCR54 receptor. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are necessary for reproductive activity, are secreted under the direction of GnRH.

Moreover, Kisspeptin has been linked to the relationship between reproduction and metabolism. It is believed to be crucial in establishing a connection between fertility and energy balance, demonstrating its relevance to the body’s functioning needs. Since kisspeptin was first found to be a gene that might suppress melanoma and breast cancer metastasis, it may also play a role in suppressing cancer metastasis.

Specifications

Molecular Formula: C258H401N79O78
Molecular Weight: 5857 g/mol
Sequence: Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe NH

Size: 15ml | 30ml

Kisspeptin Research

Testosterone

Kisspeptin nasal spray has been shown to alter luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby altering testosterone levels. However, on the other hand, Kisspeptin has been found to have no effect on testosterone in female mice.

Six male mice were given Kisspeptin intravenously in a clinical study. Results showed Kisspeptin to be an effective testosterone booster in just 90 minutes [1]. In another animal study, Kisspeptin increased serum luteinizing hormone levels, which also increased testosterone levels in healthy male mice [2].

Fertility

As proven by many clinical studies the hormone Kisspeptin is shown to be a successful in the treatment of infertility. Kisspeptin nasal spray can have a substantial positive effect on infertility, according to research. Moreover, it may even be safer for mice undergoing in vitro fertilization than using chorionic gonadotropin to stimulate oocyte maturation.

Before beginning IVF treatment, none of the mice given kisspeptin-10 developed ovarian hyperstimulation syndrome (OHSS), according to studies. This is excellent news, considering that just 3-6 per cent of mice treated with the HCG peptide develop the illness.

Mood

Kisspeptin protein has the capacity to influence mood and behaviour due to the strong connection between reproduction and emotion.

In a study, Kisspeptin nasal spray was given to 29 male mice, whereas a placebo was given to a second group. Those that took kisspeptin-10 reported to experience an improvement in mood, motivation, and limbic brain activity. Compared to the control group who did not show any improvement in their symptoms. In this study, Kisspeptin was found to affect both sexual and emotional brain functions in mice and their general behaviour [3].

Cancer

Kisspeptin may help prevent cancer by slowing the spread of cancer cells and preventing them from proliferating, according to research on the protein and cancer. Studies indicate that kisspeptin signalling could be a major factor in a number of different types of cancer, which makes it a possible target for innovative treatment strategies. Promising results have been observed in the inhibition of tumour metastasis and the function of the kisspeptin peptide system as a metastasis suppressor in breast cancer and other malignancies.

Kisspeptin’s participation in cancer-related processes outside of reproductive biology has also been highlighted by its role in placentation and trophoblast invasion. These discoveries show promise for future developments in cancer treatment, even though more research is necessary to completely understand the pathways and create targeted medicines [4].

Summary

Kisspeptin is a peptide hormone that is essential for controlling reproductive processes. It is expressed by the KISS1 gene and acts on the hypothalamic-pituitary-gonadal axis to increase the release of gonadotropin-releasing hormone (GnRH), which subsequently leads to the synthesis of reproductive hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Kisspeptin plays a role in the timing of reproductive cycles, the regulation of fertility, and the start of puberty. It has also been discovered to offer medicinal potential in the treatment of infertility. In addition, kisspeptin’s potential as a tumour growth inhibitor and a suppressor of breast cancer metastasis has been investigated in relation to cancer. The numerous roles and therapeutic ramifications of kisspeptin in reproductive health and beyond its application in research are still being investigated.

References

[1] https://www.researchgate.net/ publication/7588637

[2] https://academic.oup.com/jcem/ article/96/8/E1228/2833644

[3] https://pubmed.ncbi.nlm.nih. gov/ 28112678/

[4] https://www.sciencedirect.com/ science/article/abs/pii/S0305737 208002016

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