PT-141 Bremelanotide Nasal Spray

Description

PT-141 Nasal Spray

PT-141 Nasal Spray is a peptide that increases the production of nitric oxide in the body, thus allowing the blood vessels to open up, increasing the blood flow to the penis, making it more significant, and thus enabling a man to have an erection that lasts for a more extended period.

This peptides will not eliminate the low libido, they will reduce it. In addition to being able to lessen the risk of sex, the lower desire can cause a couple of problems such as reduced satisfaction from sex, or even a decreased sex drive altogether, which is not desirable.

Pt141 is used to improve sexual desire in men and increase erections. Pt-141 is even considered to be “pumps” that can increase blood flow to the penis, allowing for better erections.

What’s PT-141?

Bremelanotide, a brand name for PT-141, has been dubbed “the female Viagra” due to its usage in treating female hypoactive sexual drive disorder in phase llb human clinical trials (HSDD). PT-141 is a melanocortin that primarily binds to the MC-4R and MC-1R receptors. Acute bleeding may be treated with PT-141, according to research conducted in 2009. Melanotan 2 is another synthetic melanocortin from which PT-141 is derived (MT 2)

Specifications

Molecular Formula: C50H68N14O10

Molecular Weight: 1025.2 g/mol

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

Size: 15ml | 30ml

Research

Sexual dysfunction

PT-141 nasal spray is a unique peptide because it activates the MC-4R, affecting sexual desire and behaviour. Agonist binding to MC-4R induces sexual excitement and enhanced copulation in male and female mice. Because PT-141 nasal spray works differently than medications like Viagra, it can treat sexual arousal issues in men and women that aren’t caused by diminished genital blood flow [1].

Unresponsive to sildenafil (Viagra), around one-third of males with ED achieved satisfactory erections for sexual intercourse with PT-141 (administered via nasal spray) [2]. In addition, the trial showed a robust dose-dependent response, showing that PT 141 is beneficial in some situations. This indicates that PT-141 may help fix ED when sildenafil has been unsuccessful and may help understand the hypoactive sexual drive [3].

In HSDD sufferers, it was discontinued from clinical trials. Unbelievably, the drug-enhanced monthly happy sexual experiences and decreased scores of women’s sexual distress without causing significant adverse effects. Many FSD experts were disappointed to learn that the protein was not being further developed despite promising results. The absence of clear endpoints for FSD trials and cultural preconceptions against females’ sexual health is blamed for the delays [4].

They expect the FDA to create more specific guidelines for examining potentially useful drugs like PT-141. The expert group was also disappointed that the pharmacological treatments were not combined with other proven approaches to treating sexual dysfunction. In addition, they believe peptides like PT-141 Nasal Spray Bremelanotide may help overcome initial barriers and initiate psychiatric treatment.

Phase II Reconnect studies using subcutaneous PT141 injections for FSD started in 2017, partly due to discontinued past trials. Rekynda, the newest PT-141 variant, may soon be available in the US.

Hemorrhage

To treat hemorrhagic shock, PT-141 nasal spray Bremelanotide was slightly modified in 2009. It decreases ischemia and protects tissues from hypovolemic (hemorrhagic) shock by binding to MC-1R and MC-4R molecules. The medication has no significant adverse effects when given intravenously.

Infection

Researchers discovered that the MC-1R possesses potent antifungal and anti-inflammatory effects in a rat model of a specific fungal infection. Notably, current antifungals have limited mechanisms of action and induce substantial, treatment-limiting adverse effects in particular individuals. A treatment option for fungal infections could significantly reduce morbidity and death, especially in immunocompromised individuals [5].

Cancer research

The MC-1R receptor stimulates DNA repair pathways, making it useful in cancer treatment and prevention [6]. People with MC-1R mutations have an increased risk of basal cell and squamous cell carcinoma. Altered PT-141 may be able to treat or prevent malignancies caused by certain variations [7].

Summary

Sexual dysfunction is currently the focus of most research on PT-141 nasal spray. However, its use is not limited to sexual dysfunction or bleeding. Thus, MC-4R deficiency or absence is associated with up to 6% of all cases of early-onset obesity, according to some estimates. PT-141 nasal spray allows us to investigate this particular cause of obesity and show a possible intervention option. MC-1R is involved in pain, inflammation, kidney disease, and infection dissemination.

References

1. https://pubmed.ncbi.nlm.nih.gov/14999221/
2. https://pubmed.ncbi.nlm.nih.gov/18206919/
3. https://pubmed.ncbi.nlm.nih.gov/17113634/
4. https://pubmed.ncbi.nlm.nih.gov/27181790/
5. https://pubmed.ncbi.nlm.nih.gov/23457491/
6. https://pubmed.ncbi.nlm.nih.gov/25786343/
7. https://pubmed.ncbi.nlm.nih.gov/26850723/

Buy PT-141 Nasal Spray Bremelanotide Peptide 15ml and 30ml

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