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PT-141 Bremelanotide Nasal Spray

PT-141 nasal spray is a significantly modified synthetic version of alpha-melanocyte-stimulating hormone. It has been used in clinic trials to treat Male/female hypoactive sex drive problem and acute bleeding. PT-141 binds to the melanocortin-4 and 1 receptors to improve sexual arousal and the immunological system.

10ml contains 10mg PT-141 Peptide

30ml contains 25mg PT-141 Peptide

Make a 10% saving with a Twin Pack!


SKU PT141 Nasal Spray Categories , ,


PT-141 Nasal Spray

PT-141 Nasal Spray increases the production of nitric oxide in the body, thus allowing the blood vessels to open up, increasing the blood flow to the penis, which can increase the time in which a man can have an erection.

PT-141 cannot eliminate low libido, but it can reduce it. In addition to not being able to perform sexually, the lower desire can also cause problems such as reduced satisfaction from sex, or even a decreased sex drive altogether, which is not desirable.

Pt141 can be used to improve sexual desire in men and increase erections. Pt-141 is even considered to increase blood flow to the penis, allowing for better erections.

What’s PT-141?

In addition to helping men with sexual problems, Bremelanotide, a brand name for PT-141, has been dubbed “the female Viagra” due to its success in treating female hypoactive sexual drive disorder in human clinical trials (HSDD). PT-141 is a melanocortin that primarily binds to the MC-4R and MC-1R receptors. Acute bleeding may also be treated with PT-141, according to clinical studies conducted in 2009. Melanotan 2 is another synthetic melanocortin from which PT-141 is derived (MT 2)


Molecular Formula: C50H68N14O10

Molecular Weight: 1025.2 g/mol

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

Size: 15ml | 30ml


Sexual dysfunction

PT-141 nasal spray is a unique peptide because it activates the MC-4R, affecting sexual desire and behaviour. Agonist binding to MC-4R induces sexual arousal and enhanced copulation in male and female mice. PT-141 nasal spray works differently than medications like Viagra, as it can treat sexual arousal issues in men and women that aren’t caused by diminished genital blood flow [1].

Those individuals that are unresponsive to sildenafil (Viagra), around one-third of males with erectile dysfunction achieved satisfactory erections for sexual intercourse with PT-141 (administered via nasal spray) [2]. In addition, the trial showed a robust dose-dependent response, showing that PT 141 is beneficial in some situations. This indicates that PT-141 may help fix ED when sildenafil has been unsuccessful and may help understand the hypoactive sexual drive [3].

Clinical trials using PT-141 to treat Hypoactive Sexual Desire Disorder (HSDD) have been abandoned. The drug enhanced sexual experiences and decreased sexual distress in women without causing significant adverse effects. Many Female Sexual Disorder experts were disappointed to learn that the protein was not being further developed despite promising results. The absence of clear endpoints for FSD trials and cultural preconceptions against females’ sexual health is blamed for the delays [4].

Phase II Reconnect studies using subcutaneous PT141 injections for FSD started in 2017, partly due to discontinued past trials. Rekynda, the newest PT-141 variant, may soon be available as a treatment in selected countries.


To treat hemorrhagic shock, PT-141 nasal spray Bremelanotide has been modified slightly. It has the ability to decrease ischemia and can protect tissues from hypovolemic (hemorrhagic) shock by binding to MC-1R and MC-4R molecules. Studies found that PT-141 didn’t produce significant adverse effects when given intravenously.


Researchers discovered that the MC-1R possesses potent antifungal and anti-inflammatory effects in a rodent subjects of a specific fungal infection. Notably, current antifungal medications have limited mechanisms of action and can induce substantial, treatment-limiting adverse effects in particular individuals. A treatment option for fungal infections could significantly reduce morbidity and death, especially in immunocompromised individuals [5].

Cancer research

The MC-1R receptor stimulates DNA repair pathways, making it useful in the treatment and prevention of certain cancers [6]. People with MC-1R mutations have an increased risk of basal cell and squamous cell carcinoma. Altered PT-141 may be able to treat or prevent malignancies caused by certain variations [7].


Sexual dysfunction is currently the focus of most research on PT-141 nasal spray. However, its use is not limited to sexual dysfunction or bleeding. Thus, MC-4R deficiency or absence is associated with up to 6% of all cases of early-onset obesity, according to some estimates. PT-141 nasal spray allows us to investigate this particular cause of obesity and show a possible intervention option. MC-1R is involved in pain, inflammation, kidney disease, and infection dissemination.


[1] https://pubmed.ncbi.nlm.nih.gov/ 14999221/

[2] https://pubmed.ncbi.nlm.nih.gov/ 18206919/

[3] https://pubmed.ncbi.nlm.nih.gov/ 17113634/

[4] https://pubmed.ncbi.nlm.nih.gov/ 27181790/

[5] https://pubmed.ncbi.nlm.nih.gov/ 23457491/

[6] https://pubmed.ncbi.nlm.nih.gov/ 25786343/

[7] https://pubmed.ncbi.nlm.nih.gov/ 26850723/

Buy PT-141 Nasal Spray Bremelanotide Peptide 15ml and 30ml

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Additional information

Weight 0.01 kg
Dimensions 1 × 1 × 1 cm

15ml, 30ml, Twin Pack 15ml, Twin Pack 30ml